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Displaying drugs 2251 - 2275 of 2435 in total
1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone
Experimental
Matched Categories: … Heme Oxygenase-1, antagonists & inhibitors …
PF-03463275
PF-03463275 has been used in trials studying the treatment of Schizophrenia and Cognitive Impairments Associated With Schizophrenia.
Investigational
Matched Categories: … Glycine Plasma Membrane Transport Proteins, antagonists & inhibitors …
Liarozole
Liarozole has been used in trials studying the treatment of Ichthyosis, Lamellar.
Investigational
Matched Categories: … Enzyme Inhibitors …
TAK-593
TAK-593 has been used in trials studying the treatment of Solid Tumors.
Investigational
Matched Categories: … Receptors, Platelet-Derived Growth Factor, antagonists & inhibitors …
Basic Fibroblast Growth Factor
Basic Fibroblast Growth Factor (bFGF) is a single-chain polypeptide growth factor that plays a significant role in the process of wound healing and is a potent inducer of physiologic angiogenesis. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative...
Investigational
Matched Categories: … Fibroblast Growth Factor 2, antagonists & inhibitors …
Sirukumab
Sirukumab has been used in trials studying the treatment and basic science of Giant Cell Arteritis and Arthritis, Rheumatoid.
Investigational
Matched Categories: … Interleukin Inhibitors …
Hycanthone
Potentially toxic, but effective antischistosomal agent, it is a metabolite of LUCANTHONE. Hycanthone was approved by the FDA in 1975 but is no longer used.
Experimental
Matched Categories: … P-glycoprotein inhibitors …
LY-2090314
Ly2090314 has been used in trials studying the treatment of Leukemia, Advanced Cancer, and Pancreatic Cancer.
Investigational
Matched Categories: … Glycogen Synthase Kinase 3, antagonists & inhibitors …
Merestinib
Merestinib has been used in trials studying the treatment of Cancer, Solid Tumor, Advanced cancer, ColoRectal Cancer, and Metastatic Cancer, among others.
Investigational
Matched Categories: … Protein Kinase Inhibitors …
Serplulimab
Investigational
Matched Categories: … PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitors …
Anecortave acetate
Anecortave acetate (Retaane) is an analog of cortisol acetate; among the modifications to the steroid are the removal of the 11ß hydroxyl OH group and an addition of a 21-acetate group. As a result of these modifications, anecortave acetate lacks the typical antiinflammatory and immunosuppressive properties of glucocorticoids.Alcon Inc. is...
Investigational
Matched Categories: … Angiogenesis Inhibitors …
Tandutinib
MLN518 is a novel, oral, small molecule designed to inhibit type III receptor tyrosine kinases, including FLT3, (platelet-derived growth-factor receptor) PDGFR and c-KIT. Tyrosine kinases are enzymes involved in several cellular processes and are known to be activated in cancer cells to drive tumor growth. AML patients with FLT3 mutations...
Investigational
Matched Categories: … Tyrosine Kinase Inhibitors …
Lortalamine
Lortalamine (LM-1404) is a selective norepinephrine reuptake inhibitor developed in the 1980s. This drug never made it past clinical trials, likely due to ocular toxicity in animals, but has been used in positron emission tomography studies to label norepinephrine transporters.
Experimental
Matched Categories: … Adrenergic Uptake Inhibitors …
Lenabasum
Ajulemic acid has been used in trials studying the treatment of Cystic Fibrosis, Dermatomyositis, and Diffuse Cutaneous Systemic Sclerosis.
Investigational
Matched Categories: … Interleukin-1, antagonists & inhibitors …
Luseogliflozin
Luseogliflozin has been used in trials studying the treatment of Diabetes Melltius, Type 2.
Investigational
Matched Categories: … Sodium-glucose Cotransporter 2 (SGLT2) Inhibitors …
Trandolaprilat
The active metabolite of the prodrug Trandolapril.
Experimental
Matched Categories: … Angiotensin-Converting Enzyme Inhibitors …
Fenpyroximate
Fenpyroximate is under investigation in clinical trial NCT02533336 (The Effectiveness of Non-pyrethroid Insecticide-treated Durable Wall Liners as a Method for Malaria Control in Endemic Rural Tanzania).
Investigational
Matched Categories: … Electron Transport Complex I, antagonists & inhibitors …
2,4-Dinitrophenol
A toxic dye, chemically related to trinitrophenol (picric acid), used in biochemical studies of oxidative processes where it uncouples oxidative phosphorylation. It is also used as a metabolic stimulant. (Stedman, 26th ed)
Experimental
Matched Categories: … Enzyme Inhibitors …
Forodesine
Forodesine is a highly potent, orally active, rationally designed PNP inhibitor that has shown activity in preclinical studies with malignant cells and clinical utility against T-cell acute lymphoblastic leukemia and cutaneous T-cell lymphoma. Additional preliminary findings support its use for the management of some B-cell malignancies.
Investigational
Matched Categories: … Purine-Nucleoside Phosphorylase, antagonists & inhibitors …
Zosuquidar
Zosuquidar is a compound of antineoplastic drug candidates currently under development. It is now in "Phase 3" of clinical tests in the United States. Its action mechanism consists of the inhibition of P-glycoproteins; other drugs with this mechanism include tariquidar and laniquidar.
Investigational
Matched Categories: … P-glycoprotein inhibitors …
PH-797804
PH-797804 has been investigated for the treatment of Osteoarthritis.
Investigational
Matched Categories: … p38 Mitogen-Activated Protein Kinases, antagonists & inhibitors …
Phenoxypropazine
Phenoxypropazine is a non-selective and irreversible monoamine oxidase enzyme inhibitor (MAOI), belonging to the hydrazine chemical class. It was marketed as an antidepressant in 1961 but was later withdrawn in 1966 because of its hepatotoxic potential.
Withdrawn
Matched Categories: … Monoamine Oxidase Inhibitors …
Cenicriviroc
Cenicriviroc has been used in trials studying the treatment of HIV-infection/AIDS, AIDS Dementia Complex, Nonalcoholic Steatohepatitis, Human Immunodeficiency Virus, and HIV-1-Associated Cognitive Motor Complex.
Investigational
Matched Categories: … Receptors, CCR2, antagonists & inhibitors …
Displaying drugs 2251 - 2275 of 2435 in total