Displaying drugs 2426 - 2450 of 9003 in total
3-(3-(6-Guanidino-1-oxoisoindolin-2yl)propanamido)-3-(pyridine-3yl)propanoic acid
Investigational
Matched Name: … 3-(3-(6-Guanidino-1-oxoisoindolin-2yl)propanamido)-3-(pyridine-3yl)propanoic acid …
Matched Iupac: … 3-[3-(6-carbamimidamido-1-oxo-2,3-dihydro-1H-isoindol-2-yl)propanamido]-3-(pyridin-3-yl)propanoic acid …
Matched Salts name: … 3-(3-(6-Guanidino-1-oxoisoindolin-2yl)propanamido)-3-(pyridine-3yl)propanoic acid dihydrochloride …
Matched Iupac: … 3-[3-(6-carbamimidamido-1-oxo-2,3-dihydro-1H-isoindol-2-yl)propanamido]-3-(pyridin-3-yl)propanoic acid …
Matched Salts name: … 3-(3-(6-Guanidino-1-oxoisoindolin-2yl)propanamido)-3-(pyridine-3yl)propanoic acid dihydrochloride …
JNJ-28312141
Investigational
Matched Synonyms: … 1h-imidazole-2-carboxamide, 5-cyano-n-(2-(1-cyclohexen-1-yl)-4-(1-(2-(dimethylamino)acetyl)-4-piperidinyl ... 4-cyano-N-[2-(1-cyclohexen-1-yl)-4-[1-[(dimethylamino)acetyl]-4-piperidinyl]phenyl]-1H-imidazole-2-carboxamide …
Matched Iupac: … 4-cyano-N-[2-(cyclohex-1-en-1-yl)-4-{1-[2-(dimethylamino)acetyl]piperidin-4-yl}phenyl]-1H-imidazole-2 …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Iupac: … 4-cyano-N-[2-(cyclohex-1-en-1-yl)-4-{1-[2-(dimethylamino)acetyl]piperidin-4-yl}phenyl]-1H-imidazole-2 …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
INS018_055
Investigational
Matched Synonyms: … 5’-(4-fluorophenyl)-3’-isopropyl-N-(4-(4-methylpiperazin-1-yl)phenyl)-1H,3’H-[2,4’-biimidazole]-4-carboxamide …
Matched Iupac: … 5'-(4-fluorophenyl)-N-[4-(4-methylpiperazin-1-yl)phenyl]-3'-(propan-2-yl)-3H,3'H-[2,4'-biimidazole]-4 …
Matched Iupac: … 5'-(4-fluorophenyl)-N-[4-(4-methylpiperazin-1-yl)phenyl]-3'-(propan-2-yl)-3H,3'H-[2,4'-biimidazole]-4 …
Navitoclax
Navitoclax has been used in trials studying the treatment and basic science of Solid Tumors, Non-Hodgkin's Lymphoma, EGFR Activating Mutation, Chronic Lymphoid Leukemia, and Hematological Malignancies, among others.
Navitoclax is an orally bioavailable small molecule inhibitor of Bcl-2 family proteins. It is a substance being studied in the treatment of...
Investigational
Matched Synonyms: … (R)-4-(3-Morpholin-4-Yl-1-Phenylsulfanylmethyl-Propylamino)-N-(4-{4-[2-(4-Chlorophenyl)-5,5-Dimethylcyclohex ... -1-Enylmethyl]-Piperazin-1-Yl}-Benzoyl)-3-Trifluoromethanesulfonylbenzenesulfonamide …
Matched Iupac: … 4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-(4-{[(2R)-4-(morpholin ... -4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-trifluoromethanesulfonylbenzenesulfonyl)benzamide …
Matched Description: … Navitoclax is an orally bioavailable small molecule inhibitor of Bcl-2 family proteins. …
Matched Iupac: … 4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-(4-{[(2R)-4-(morpholin ... -4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-trifluoromethanesulfonylbenzenesulfonyl)benzamide …
Matched Description: … Navitoclax is an orally bioavailable small molecule inhibitor of Bcl-2 family proteins. …
Menadione bisulfite
Experimental
Matched Iupac: … 2-methyl-1,4-dioxo-1,2,3,4-tetrahydronaphthalene-2-sulfonic acid …
Matched Salts cas: … 6147-37-1 …
Matched Salts cas: … 6147-37-1 …
Lipotecan
Investigational
Matched Synonyms: … Propanoic acid, 2-(((2,4,5,7-tetranitro-9h-fluoren-9-ylidene)amino)oxy)-, (4s)-10-((dimethylamino)methyl ... )-4-ethyl-3,4,12,14-tetrahydro-9-hydroxy-3,14-dioxo-1h-pyrano(3',4':6,7)indolizino(1,2-b)quinolin-4-yl …
Matched Iupac: … 21),2(11),3,5,7,9,15(20)-heptaen-19-yl 2-{[(2,4,5,7-tetranitro-9H-fluoren-9-ylidene)amino]oxy}propanoate ... -ethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1( …
Matched Iupac: … 21),2(11),3,5,7,9,15(20)-heptaen-19-yl 2-{[(2,4,5,7-tetranitro-9H-fluoren-9-ylidene)amino]oxy}propanoate ... -ethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1( …
3D-185 free base
Investigational
Matched Synonyms: … Benzamide, N-(6-(2,6-dichloro-3,5-dimethoxyphenyl)-1H-pyrazolo(3,4-B)pyridin-3-yl)-4-(3,3-dimethyl-1- …
Itacitinib
Itacitinib has been used in trials studying the treatment of Melanoma, Carcinoma, Metastatic Cancer, Endometrial Cancer, and B-cell Malignancies, among others.
Investigational
Matched Iupac: … 2-(1-{1-[3-fluoro-2-(trifluoromethyl)pyridine-4-carbonyl]piperidin-4-yl}-3-(4-{7H-pyrrolo[2,3-d]pyrimidin ... -4-yl}-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile …
Matched Salts cas: … 1334302-63-4 …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Salts cas: … 1334302-63-4 …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
DPM-1001
Investigational
Matched Synonyms: … methyl (R)-4-((3S,5R,7R,8R,9S,10S,13R,14S,17R)-7-hydroxy-10,13-dimethyl-3-((4-((pyridin-2-ylmethyl)amino ... Methyl (3β,5α,7α)-7-hydroxy-3-[[4-[(2-pyridinylmethyl)amino]butyl]amino]cholan-24-oate ... Cholan-24-oic acid, 7-hydroxy-3-[[4-[(2-pyridinylmethyl)amino]butyl]amino]-, methyl ester, (3β,5α,7α) …
Matched Iupac: … methyl (4R)-4-[(1R,3aS,3bR,4R,5aR,7S,9aS,9bS,11aR)-4-hydroxy-9a,11a-dimethyl-7-[(4-{[(pyridin-2-yl)methyl ... ]amino}butyl)amino]-hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]pentanoate …
Matched Iupac: … methyl (4R)-4-[(1R,3aS,3bR,4R,5aR,7S,9aS,9bS,11aR)-4-hydroxy-9a,11a-dimethyl-7-[(4-{[(pyridin-2-yl)methyl ... ]amino}butyl)amino]-hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]pentanoate …
Cudetaxestat
Investigational
Matched Synonyms: … 3-((2,6-dichloro-7-fluoro-1-(1-propyl-1h-pyrazol-4-yl)-1h-indol-3-yl)thio)-2-fluorobenzoic acid ... Benzoic acid, 3-((2,6-dichloro-7-fluoro-1-(1-propyl-1h-pyrazol-4-yl)-1h-indol-3-yl)thio)-2-fluoro- …
Matched Iupac: … 3-{[2,6-dichloro-7-fluoro-1-(1-propyl-1H-pyrazol-4-yl)-1H-indol-3-yl]sulfanyl}-2-fluorobenzoic acid …
Matched Iupac: … 3-{[2,6-dichloro-7-fluoro-1-(1-propyl-1H-pyrazol-4-yl)-1H-indol-3-yl]sulfanyl}-2-fluorobenzoic acid …
BMX-001 free base
Investigational
Matched Synonyms: … .kappa.n24)tetrakis(1-(2-butoxyethyl)pyridiniumato))(2-))-, (sp-4-1)- ... Manganese(5+), ((2,2',2'',2'''-(21h,23h-porphine-5,10,15,20-tetrayl-.kappa.n21,.kappa.n22,.kappa.n23, …
Matched Iupac: … manganese(3+) 2,7,12,17-tetrakis[1-(2-butoxyethyl)pyridin-1-ium-2-yl]-21,22,23,24-tetraazapentacyclo[ ... 16.2.1.1^{3,6}.1^{8,11}.1^{13,16}]tetracosa-1(20),2,4,6(24),7,9,11,13(22),14,16,18-undecaene-21,23-diide …
Matched Salts cas: … 1379783-91-1 …
Matched Iupac: … manganese(3+) 2,7,12,17-tetrakis[1-(2-butoxyethyl)pyridin-1-ium-2-yl]-21,22,23,24-tetraazapentacyclo[ ... 16.2.1.1^{3,6}.1^{8,11}.1^{13,16}]tetracosa-1(20),2,4,6(24),7,9,11,13(22),14,16,18-undecaene-21,23-diide …
Matched Salts cas: … 1379783-91-1 …
H3B-8800
H3B-8800 is a novel spliceosome inhibitor developed by H3 Biomedicine . It offers the benefit of preferentially killing spliceosome-mutant cancer cells whereas other splicesome inhibitors, such as the pladienolide analogue E7107, show no such preferential targeting . H3B-8800 was granted orphan drug status by the FDA in August 2017 and...
Investigational
Matched Synonyms: … 2-Yl]Oxacyclododec-4-En-6-Yl 4-Methylpiperazine-1-Carboxylate ... )-1-METHYL-5-(2-PYRIDINYL)-1,3-HEXADIEN-1-YL)-12-OXOOXACYCLODODEC-4-EN-6-YL ESTER ... -yl]oxacyclododec-4-en-6-yl 4-methyl-1-piperazinecarboxylate …
Matched Iupac: … ]-1-oxacyclododec-4-en-6-yl 4-methylpiperazine-1-carboxylate ... (2S,3S,4E,6S,7R,10R)-7,10-dihydroxy-3,7-dimethyl-12-oxo-2-[(4E,6R)-6-(pyridin-2-yl)hepta-2,4-dien-2-yl …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Iupac: … ]-1-oxacyclododec-4-en-6-yl 4-methylpiperazine-1-carboxylate ... (2S,3S,4E,6S,7R,10R)-7,10-dihydroxy-3,7-dimethyl-12-oxo-2-[(4E,6R)-6-(pyridin-2-yl)hepta-2,4-dien-2-yl …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Ibutamoren
Investigational
Matched Synonyms: … 2-amino-n-((r)-2-(benzyloxy)-1-((1-(methylsulfonyl)spiro(indoline-3,4'-piperidin)-1'-yl)carbonyl)ethyl ... 2-amino-n-(3-(benzyloxy)-1-(1-methanesulfonyl-1,2-dihydrospiro(indole-3,4'-piperidin)-1'-yl)-1-oxopropan ... -2-yl)-2-methylpropanamide …
Matched Iupac: … 2-amino-N-[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-dihydrospiro[indole-3,4'-piperidin]-1'-yl}-1-oxopropan ... -2-yl]-2-methylpropanamide …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Iupac: … 2-amino-N-[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-dihydrospiro[indole-3,4'-piperidin]-1'-yl}-1-oxopropan ... -2-yl]-2-methylpropanamide …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Muparfostat
Muparfostat (PI-88) is a mixture of highly sulfated, monophosphorylated mannose oligosaccharides, derived from the extracellular phosphomannan of the yeast Pichia (Hansenula) holstii, with potential antiangiogenic activity.
Investigational
Matched Synonyms: … -D-MANNAN, (1->3)-, 6-(DIHYDROGEN PHOSPHATE) TRIS(HYDROGEN SULFATE) …
Matched Iupac: … }oxan-4-yl]oxy}-6-[(phosphonooxy)methyl]-4,5-bis(sulfooxy)oxan-3-yl)oxidanesulfonic acid ... (2-{[3,5-bis(sulfooxy)-2-[(sulfooxy)methyl]-6-{[2,4,5-tris(sulfooxy)-6-[(sulfooxy)methyl]oxan-3-yl]oxy …
Matched Iupac: … }oxan-4-yl]oxy}-6-[(phosphonooxy)methyl]-4,5-bis(sulfooxy)oxan-3-yl)oxidanesulfonic acid ... (2-{[3,5-bis(sulfooxy)-2-[(sulfooxy)methyl]-6-{[2,4,5-tris(sulfooxy)-6-[(sulfooxy)methyl]oxan-3-yl]oxy …
KUS-121 free acid
Investigational
Matched Synonyms: … 1-Naphthalenesulfonic acid, 4-amino-3-[2-[6-(4-fluoro-2-methylphenyl)-3-pyridinyl]diazenyl]- ... 4-Amino-3-[[6-(4-fluoro-2-methylphenyl)pyridin-3-yl]azo]naphthalene-1-sulfonic acid …
Matched Iupac: … 4-amino-3-[(1E)-2-[6-(4-fluoro-2-methylphenyl)pyridin-3-yl]diazen-1-yl]naphthalene-1-sulfonic acid …
Matched Salts cas: … 2603172-24-1 …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Iupac: … 4-amino-3-[(1E)-2-[6-(4-fluoro-2-methylphenyl)pyridin-3-yl]diazen-1-yl]naphthalene-1-sulfonic acid …
Matched Salts cas: … 2603172-24-1 …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
JTC-801 free base
An antagonist of nociceptin receptor and analgesic agent, evaluated for its use in cancer treatment.
Investigational
Matched Synonyms: … Benzamide, n-(4-amino-2-methyl-6-quinolinyl)-2-((4-ethylphenoxy)methyl)- …
Matched Iupac: … N-(4-amino-2-methylquinolin-6-yl)-2-[(4-ethylphenoxy)methyl]benzamide …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Iupac: … N-(4-amino-2-methylquinolin-6-yl)-2-[(4-ethylphenoxy)methyl]benzamide …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Tuspetinib
Tuspetinib (HM-43239) is under investigation in clinical trial NCT03850574 (Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HM43239 in Patients With Relapsed or Refractory Acute Myeloid Leukemia).
Investigational
Matched Synonyms: … 2-Pyrimidinamine, 5-chloro-N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethyl-1-piperazinyl)methyl)phenyl)-4-( ... 5-Chloro-N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethylpiperazine-1-yl) methyl) phenyl)-4-(6-methyl-1hindol ... -3-yl) pyrimidin-2-amine …
Matched Iupac: … 5-chloro-N-(3-cyclopropyl-5-{[(3R,5S)-3,5-dimethylpiperazin-1-yl]methyl}phenyl)-4-(6-methyl-1H-indol- ... 3-yl)pyrimidin-2-amine …
Matched Iupac: … 5-chloro-N-(3-cyclopropyl-5-{[(3R,5S)-3,5-dimethylpiperazin-1-yl]methyl}phenyl)-4-(6-methyl-1H-indol- ... 3-yl)pyrimidin-2-amine …
2,4-Dihydroxy-7-(Methyloxy)-2h-1,4-Benzoxazin-3(4h)-One
Experimental
Matched Iupac: … (2R)-2,4-dihydroxy-7-methoxy-3,4-dihydro-2H-1,4-benzoxazin-3-one …
Cilofexor
Cilofexor is under investigation in clinical trial NCT02943447 (Safety, Tolerability, and Efficacy of Cilofexor in Adults With Primary Biliary Cholangitis Without Cirrhosis).
Investigational
Matched Synonyms: … -1-yl]pyridine-4-carboxylic acid ... 2-[3-(2-chloro-4-{[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy}phenyl)-3-hydroxyazetidin …
Matched Iupac: … -1-yl]pyridine-4-carboxylic acid ... 2-[3-(2-chloro-4-{[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy}phenyl)-3-hydroxyazetidin …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Iupac: … -1-yl]pyridine-4-carboxylic acid ... 2-[3-(2-chloro-4-{[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy}phenyl)-3-hydroxyazetidin …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Inavolisib
Inavolisib (GDC-0077) is under investigation in clinical trial NCT03006172 (To Evaluate the Safety, Tolerability, and Pharmacokinetics of GDC-0077 Single Agent in Participants With Solid Tumors and in Combination With Endocrine and Targeted Therapies in Participants With Breast Cancer).
Investigational
Matched Synonyms: … (2S)-2-((2-((4S)-4-(difluoromethyl)-2-oxo-3-oxazolidinyl)-5,6-dihydroimidazo(1,2-D)(1,4)benzoxazepin- ... propanamide, 2-((2-((4S)-4-(difluoromethyl)-2-oxo-3-oxazolidinyl)-5,6-dihydroimidazo(1,2-D)(1,4)benzoxazepin …
Matched Iupac: … (2S)-2-({4-[(4S)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-9-oxa-3,6-diazatricyclo[8.4.0.0^{2,6}] ... tetradeca-1(14),2,4,10,12-pentaen-12-yl}amino)propanamide …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Iupac: … (2S)-2-({4-[(4S)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-9-oxa-3,6-diazatricyclo[8.4.0.0^{2,6}] ... tetradeca-1(14),2,4,10,12-pentaen-12-yl}amino)propanamide …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Aldosterone
A hormone secreted by the adrenal cortex that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.
Experimental
Investigational
Matched Synonyms: … (11β)-11,21-dihydroxy-3,20-dioxopregn-4-en-18-al ... 11beta,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al ... 11beta,21-dihydroxy-3,20-dioxopregn-4-en-18-al …
Matched Iupac: … (1S,3aS,3bS,9aR,9bS,10S,11aR)-10-hydroxy-1-(2-hydroxyacetyl)-9a-methyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H …
Matched Iupac: … (1S,3aS,3bS,9aR,9bS,10S,11aR)-10-hydroxy-1-(2-hydroxyacetyl)-9a-methyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H …
KTX-1001
Investigational
Matched Synonyms: … (S)-1-((R)-3-amino-1-(4-((6-amino-9H-purin-9-yl)methyl)-6-(2,5-difluoro-4-methoxyphenyl)pyridin-3-yl) ... piperidin-3-yl)-2,2-difluoroethan-1-ol …
Isoliquiritigenin
Isoliquiritigenin is a precursor to several flavonones in many plants.
Experimental
Matched Synonyms: … (E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propene-1-one ... (E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-propenone ... 2',4,4'-Trihydroxychalcone …
Matched Iupac: … (2E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Heterocyclic Compounds, 2-Ring …
Matched Iupac: … (2E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Heterocyclic Compounds, 2-Ring …
N-(4-(1-cyclopropyl-4-fluoro-2-methyl-1H-benzo(d)imidazol-6-yl)-5-fluoropyrimidin-2-yl)-6-(2-(dimethylamino)ethyl)-5,6,7,8-tetrahydro-l,6-naphthyridin-2-amine
Investigational
Matched Name: … N-(4-(1-cyclopropyl-4-fluoro-2-methyl-1H-benzo(d)imidazol-6-yl)-5-fluoropyrimidin-2-yl)-6-(2-(dimethylamino ... )ethyl)-5,6,7,8-tetrahydro-l,6-naphthyridin-2-amine …
Matched Iupac: … N-[4-(1-cyclopropyl-4-fluoro-2-methyl-1H-1,3-benzodiazol-6-yl)-5-fluoropyrimidin-2-yl]-6-[2-(dimethylamino ... )ethyl]-5,6,7,8-tetrahydro-1,6-naphthyridin-2-amine …
Matched Salts cas: … 2765997-88-2 …
Matched Iupac: … N-[4-(1-cyclopropyl-4-fluoro-2-methyl-1H-1,3-benzodiazol-6-yl)-5-fluoropyrimidin-2-yl]-6-[2-(dimethylamino ... )ethyl]-5,6,7,8-tetrahydro-1,6-naphthyridin-2-amine …
Matched Salts cas: … 2765997-88-2 …
Displaying drugs 2426 - 2450 of 9003 in total