The sodium bicarbonate cotransporter: structure, function, and regulation.
Article Details
- CitationCopy to clipboard
Bernardo AA, Bernardo CM, Espiritu DJ, Arruda JA
The sodium bicarbonate cotransporter: structure, function, and regulation.
Semin Nephrol. 2006 Sep;26(5):352-60.
- PubMed ID
- 17071329 [ View in PubMed]
- Abstract
The role of the Na(+)-coupled HCO(3)(-) transporter (NBC) family is indispensable in acid-base homeostasis. Almost all tissues express a member of the NBC family. NBC has been studied extensively in the kidney and plays a role in proximal tubule HCO(3)(-) reabsorption. Although the exact function of this transporter family on other tissues is not very clear, the ubiquitous expression of NBC family suggests a role in cell pH regulation. Altered NBC activity caused by mutations of the gene responsible for NBC protein expression results in pathophysiologic conditions. Mutations of NBC resulting in important clinical disorders have been reported extensively on one member of the NBC family, the kidney NBC (NBC1). These mutations have led to several structural studies to understand the mechanism of the abnormal NBC1 activity.
DrugBank Data that Cites this Article
- Drug Transporters
Drug Transporter Kind Organism Pharmacological Action Actions Sodium bicarbonate Electrogenic sodium bicarbonate cotransporter 1 Protein Humans UnknownSubstrateDetails Sodium bicarbonate Electrogenic sodium bicarbonate cotransporter 4 Protein Humans UnknownSubstrateDetails Sodium bicarbonate Electroneutral sodium bicarbonate exchanger 1 Protein Humans UnknownSubstrateDetails Sodium bicarbonate Sodium bicarbonate cotransporter 3 Protein Humans UnknownSubstrateDetails Sodium bicarbonate Sodium-driven chloride bicarbonate exchanger Protein Humans UnknownSubstrateDetails