Brexpiprazole: First Global Approval.
Article Details
- CitationCopy to clipboard
Greig SL
Brexpiprazole: First Global Approval.
Drugs. 2015 Sep;75(14):1687-97. doi: 10.1007/s40265-015-0462-2.
- PubMed ID
- 26310190 [ View in PubMed]
- Abstract
Brexpiprazole (Rexulti(R)) is an atypical antipsychotic that has been developed by Otsuka Pharmaceutical Co. Ltd and H. Lundbeck A/S as an oral treatment for several psychiatric disorders. Brexpiprazole is a novel serotonin-dopamine activity modulator that acts as a partial agonist of serotonin 1A (5-HT1A) and dopamine D2 receptors, as well as a potent antagonist of 5-HT2A receptors and noradrenergic alpha1B and alpha2C receptors. In July 2015, brexpiprazole received its first approval in the USA for use as an adjunctive treatment of major depressive disorder (MDD) and the treatment of schizophrenia. In several countries, brexpiprazole is in development for MDDs, schizophrenia, post-traumatic stress disorder and agitation in patients with dementia of the Alzheimer's type. This article summarizes the milestones in the development of brexpiprazole leading to its first global approval in MDD and schizophrenia.
DrugBank Data that Cites this Article
- Drugs
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Brexpiprazole 5-hydroxytryptamine receptor 1A Protein Humans UnknownPartial agonistDetails Brexpiprazole 5-hydroxytryptamine receptor 2A Protein Humans UnknownAntagonistDetails Brexpiprazole 5-hydroxytryptamine receptor 2B Protein Humans UnknownAntagonistDetails Brexpiprazole 5-hydroxytryptamine receptor 7 Protein Humans UnknownAntagonistDetails Brexpiprazole Alpha-1A adrenergic receptor Protein Humans UnknownAntagonistDetails Brexpiprazole Alpha-1B adrenergic receptor Protein Humans UnknownAntagonistDetails Brexpiprazole Alpha-2C adrenergic receptor Protein Humans UnknownAntagonistDetails Brexpiprazole Dopamine D2 receptor Protein Humans UnknownPartial agonistDetails Brexpiprazole Histamine H1 receptor Protein Humans UnknownAntagonistDetails Brexpiprazole Muscarinic acetylcholine receptor M1 Protein Humans UnknownAntagonistDetails - Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Brexpiprazole Cytochrome P450 2D6 Protein Humans NoSubstrateDetails Brexpiprazole Cytochrome P450 3A4 Protein Humans NoSubstrateDetails - Drug Reactions
Reaction Details
