Cytochrome P450 2D6

Details

Name
Cytochrome P450 2D6
Synonyms
  • 1.14.14.1
  • Cholesterol 25-hydroxylase
  • CYP2DL1
  • CYPIID6
  • Cytochrome P450-DB1
  • Debrisoquine 4-hydroxylase
Gene Name
CYP2D6
Organism
Humans
Amino acid sequence
>lcl|BSEQ0004641|Cytochrome P450 2D6
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
Number of residues
497
Molecular Weight
55768.94
Theoretical pI
7.26
GO Classification
Functions
arachidonic acid epoxygenase activity / aromatase activity / drug binding / heme binding / iron ion binding / monooxygenase activity / oxidoreductase activity / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen / oxygen binding / steroid hydroxylase activity
Processes
alkaloid catabolic process / alkaloid metabolic process / arachidonic acid metabolic process / coumarin metabolic process / drug catabolic process / drug metabolic process / exogenous drug catabolic process / heterocycle metabolic process / isoquinoline alkaloid metabolic process / monoterpenoid metabolic process / negative regulation of binding / negative regulation of cellular organofluorine metabolic process / oxidation-reduction process / oxidative demethylation / small molecule metabolic process / steroid metabolic process / xenobiotic metabolic process
Components
cytoplasm / endoplasmic reticulum / endoplasmic reticulum membrane / mitochondrion
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Endoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0019275|Cytochrome P450 2D6 (CYP2D6)
ATGGGGCTAGAAGCACTGGTGCCCCTGGCCGTGATAGTGGCCATCTTCCTGCTCCTGGTG
GACCTGATGCACCGGCGCCAACGCTGGGCTGCACGCTACCCACCAGGCCCCCTGCCACTG
CCCGGGCTGGGCAACCTGCTGCATGTGGACTTCCAGAACACACCATACTGCTTCGACCAG
TTGCGGCGCCGCTTCGGGGACGTGTTCAGCCTGCAGCTGGCCTGGACGCCGGTGGTCGTG
CTCAATGGGCTGGCGGCCGTGCGCGAGGCGCTGGTGACCCACGGCGAGGACACCGCCGAC
CGCCCGCCTGTGCCCATCACCCAGATCCTGGGTTTCGGGCCGCGTTCCCAAGGGGTGTTC
CTGGCGCGCTATGGGCCCGCGTGGCGCGAGCAGAGGCGCTTCTCCGTGTCCACCTTGCGC
AACTTGGGCCTGGGCAAGAAGTCGCTGGAGCAGTGGGTGACCGAGGAGGCCGCCTGCCTT
TGTGCCGCCTTCGCCAACCACTCCGGACGCCCCTTTCGCCCCAACGGTCTCTTGGACAAA
GCCGTGAGCAACGTGATCGCCTCCCTCACCTGCGGGCGCCGCTTCGAGTACGACGACCCT
CGCTTCCTCAGGCTGCTGGACCTAGCTCAGGAGGGACTGAAGGAGGAGTCGGGCTTTCTG
CGCGAGGTGCTGAATGCTGTCCCCGTCCTCCTGCATATCCCAGCGCTGGCTGGCAAGGTC
CTACGCTTCCAAAAGGCTTTCCTGACCCAGCTGGATGAGCTGCTAACTGAGCACAGGATG
ACCTGGGACCCAGCCCAGCCCCCCCGAGACCTGACTGAGGCCTTCCTGGCAGAGATGGAG
AAGGCCAAGGGGAACCCTGAGAGCAGCTTCAATGATGAGAACCTGCGCATAGTGGTGGCT
GACCTGTTCTCTGCCGGGATGGTGACCACCTCGACCACGCTGGCCTGGGGCCTCCTGCTC
ATGATCCTACATCCGGATGTGCAGCGCCGTGTCCAACAGGAGATCGACGACGTGATAGGG
CAGGTGCGGCGACCAGAGATGGGTGACCAGGCTCACATGCCCTACACCACTGCCGTGATT
CATGAGGTGCAGCGCTTTGGGGACATCGTCCCCCTGGGTGTGACCCATATGACATCCCGT
GACATCGAAGTACAGGGCTTCCGCATCCCTAAGGGAACGACACTCATCACCAACCTGTCA
TCGGTGCTGAAGGATGAGGCCGTCTGGGAGAAGCCCTTCCGCTTCCACCCCGAACACTTC
CTGGATGCCCAGGGCCACTTTGTGAAGCCGGAGGCCTTCCTGCCTTTCTCAGCAGGCCGC
CGTGCATGCCTCGGGGAGCCCCTGGCCCGCATGGAGCTCTTCCTCTTCTTCACCTCCCTG
CTGCAGCACTTCAGCTTCTCGGTGCCCACTGGACAGCCCCGGCCCAGCCACCATGGTGTC
TTTGCTTTCCTGGTGAGCCCATCCCCCTATGAGCTTTGTGCTGTGCCCCGCTAG
Chromosome Location
22
Locus
22q13.1
External Identifiers
ResourceLink
UniProtKB IDP10635
UniProtKB Entry NameCP2D6_HUMAN
GenBank Protein ID181350
GenBank Gene IDM20403
GenAtlas IDCYP2D6
HGNC IDHGNC:2625
General References
  1. Gonzalez FJ, Vilbois F, Hardwick JP, McBride OW, Nebert DW, Gelboin HV, Meyer UA: Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22. Genomics. 1988 Feb;2(2):174-9. [Article]
  2. Gonzalez FJ, Skoda RC, Kimura S, Umeno M, Zanger UM, Nebert DW, Gelboin HV, Hardwick JP, Meyer UA: Characterization of the common genetic defect in humans deficient in debrisoquine metabolism. Nature. 1988 Feb 4;331(6155):442-6. [Article]
  3. Kimura S, Umeno M, Skoda RC, Meyer UA, Gonzalez FJ: The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene. Am J Hum Genet. 1989 Dec;45(6):889-904. [Article]
  4. Gaedigk A, Bhathena A, Ndjountche L, Pearce RE, Abdel-Rahman SM, Alander SW, Bradford LD, Rogan PK, Leeder JS: Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans. Pharmacogenomics J. 2005;5(3):173-82. [Article]
  5. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al.: The DNA sequence of human chromosome 22. Nature. 1999 Dec 2;402(6761):489-95. [Article]
  6. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  7. Honda A, Miyazaki T, Ikegami T, Iwamoto J, Maeda T, Hirayama T, Saito Y, Teramoto T, Matsuzaki Y: Cholesterol 25-hydroxylation activity of CYP3A. J Lipid Res. 2011 Aug;52(8):1509-16. doi: 10.1194/jlr.M014084. Epub 2011 May 16. [Article]
  8. Rowland P, Blaney FE, Smyth MG, Jones JJ, Leydon VR, Oxbrow AK, Lewis CJ, Tennant MG, Modi S, Eggleston DS, Chenery RJ, Bridges AM: Crystal structure of human cytochrome P450 2D6. J Biol Chem. 2006 Mar 17;281(11):7614-22. Epub 2005 Dec 13. [Article]
  9. Tyndale R, Aoyama T, Broly F, Matsunaga T, Inaba T, Kalow W, Gelboin HV, Meyer UA, Gonzalez FJ: Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype. Pharmacogenetics. 1991 Oct;1(1):26-32. [Article]
  10. Yokota H, Tamura S, Furuya H, Kimura S, Watanabe M, Kanazawa I, Kondo I, Gonzalez FJ: Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism. Pharmacogenetics. 1993 Oct;3(5):256-63. [Article]
  11. Evert B, Griese EU, Eichelbaum M: A missense mutation in exon 6 of the CYP2D6 gene leading to a histidine 324 to proline exchange is associated with the poor metabolizer phenotype of sparteine. Naunyn Schmiedebergs Arch Pharmacol. 1994 Oct;350(4):434-9. [Article]
  12. Daly AK, Leathart JB, London SJ, Idle JR: An inactive cytochrome P450 CYP2D6 allele containing a deletion and a base substitution. Hum Genet. 1995 Mar;95(3):337-41. [Article]
  13. Masimirembwa C, Persson I, Bertilsson L, Hasler J, Ingelman-Sundberg M: A novel mutant variant of the CYP2D6 gene (CYP2D6*17) common in a black African population: association with diminished debrisoquine hydroxylase activity. Br J Clin Pharmacol. 1996 Dec;42(6):713-9. [Article]
  14. Marez D, Legrand M, Sabbagh N, Lo-Guidice JM, Boone P, Broly F: An additional allelic variant of the CYP2D6 gene causing impaired metabolism of sparteine. Hum Genet. 1996 May;97(5):668-70. [Article]
  15. Marez D, Legrand M, Sabbagh N, Lo Guidice JM, Spire C, Lafitte JJ, Meyer UA, Broly F: Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution. Pharmacogenetics. 1997 Jun;7(3):193-202. [Article]
  16. Wang SL, Lai MD, Huang JD: G169R mutation diminishes the metabolic activity of CYP2D6 in Chinese. Drug Metab Dispos. 1999 Mar;27(3):385-8. [Article]
  17. Solus JF, Arietta BJ, Harris JR, Sexton DP, Steward JQ, McMunn C, Ihrie P, Mehall JM, Edwards TL, Dawson EP: Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population. Pharmacogenomics. 2004 Oct;5(7):895-931. [Article]
  18. Dai DP, Geng PW, Wang SH, Cai J, Hu LM, Nie JJ, Hu JH, Hu GX, Cai JP: In vitro functional assessment of 22 newly identified CYP2D6 allelic variants in the Chinese population. Basic Clin Pharmacol Toxicol. 2015 Jul;117(1):39-43. doi: 10.1111/bcpt.12363. Epub 2015 Jan 14. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00176Fluvoxamineapproved, investigationalunknownsubstrateinhibitorDetails
DB00182Amphetamineapproved, illicit, investigationalunknownsubstrateDetails
DB00185CevimelineapprovedunknownsubstrateDetails
DB00193Tramadolapproved, investigationalunknownsubstrateDetails
DB00243Ranolazineapproved, investigationalnosubstrateinhibitorDetails
DB00264Metoprololapproved, investigationalunknownsubstrateinhibitorDetails
DB00281Lidocaineapproved, vet_approvedunknownsubstrateinhibitorDetails
DB00285VenlafaxineapprovedunknownsubstrateinhibitorDetails
DB00289AtomoxetineapprovedunknownsubstrateDetails
DB00318Codeineapproved, illicitunknownsubstrateDetails
DB00370MirtazapineapprovedunknownsubstrateDetails
DB00373TimololapprovedunknownsubstrateDetails
DB00379Mexiletineapproved, investigationalunknownsubstrateDetails
DB00433Prochlorperazineapproved, vet_approvedunknownsubstrateDetails
DB00454MeperidineapprovedunknownsubstrateDetails
DB00476DuloxetineapprovedunknownsubstrateinhibitorDetails
DB00477Chlorpromazineapproved, investigational, vet_approvedunknownsubstrateinhibitorDetails
DB00496Darifenacinapproved, investigationalunknownsubstrateinhibitorDetails
DB00497Oxycodoneapproved, illicit, investigationalunknownsubstrateDetails
DB00502HaloperidolapprovedunknownsubstrateinhibitorDetails
DB00503Ritonavirapproved, investigationalunknownsubstrateinhibitorDetails
DB00514DextromethorphanapprovedunknownsubstrateDetails
DB00521CarteololapprovedunknownsubstrateDetails
DB00557HydroxyzineapprovednoinhibitorDetails
DB00574Fenfluramineapproved, illicit, investigational, withdrawnunknownsubstrateinhibitorDetails
DB00575ClonidineapprovedunknownsubstrateDetails
DB00623FluphenazineapprovedunknowninhibitorDetails
DB00647Dextropropoxypheneapproved, illicit, investigational, withdrawnunknownsubstrateinhibitorDetails
DB00656Trazodoneapproved, investigationalunknownsubstrateinhibitorDetails
DB00674GalantamineapprovednosubstrateDetails
DB00675TamoxifenapprovedunknownsubstrateinhibitorDetails
DB00679Thioridazineapproved, withdrawnunknownsubstrateinhibitorDetails
DB00699Nicergolineapproved, investigationalunknownsubstrateDetails
DB00715Paroxetineapproved, investigationalunknownsubstrateinhibitorDetails
DB00734Risperidoneapproved, investigationalunknownsubstrateinhibitorDetails
DB00757Dolasetronapproved, investigationalunknownsubstrateDetails
DB00805MinaprineapprovedunknownsubstrateDetails
DB00843DonepezilapprovedunknownsubstrateDetails
DB00850PerphenazineapprovedunknownsubstrateinhibitorDetails
DB00863Ranitidineapproved, withdrawnunknowninhibitorDetails
DB00866Alprenololexperimental, withdrawnunknownsubstrateDetails
DB00904Ondansetronapproved, withdrawnunknownsubstrateDetails
DB00914Phenforminapproved, investigational, withdrawnunknownsubstrateDetails
DB00918Almotriptanapproved, investigationalunknownsubstrateDetails
DB00934Maprotilineapproved, investigationalunknownsubstrateDetails
DB00956Hydrocodoneapproved, illicit, investigationalunknownsubstrateDetails
DB00960Pindololapproved, investigationalunknownsubstrateinhibitorDetails
DB01012CinacalcetapprovedunknowninhibitorDetails
DB01035ProcainamideapprovedunknownsubstrateDetails
DB01036Tolterodineapproved, investigationalunknownsubstrateDetails
DB01069Promethazineapproved, investigationalunknownsubstrateinhibitorDetails
DB01074Perhexilineapproved, investigationalunknownsubstrateinhibitorDetails
DB01114ChlorpheniramineapprovedunknownsubstrateinhibitorDetails
DB01136Carvedilolapproved, investigationalunknownsubstrateDetails
DB01142Doxepinapproved, investigationalnosubstrateinhibitorDetails
DB01151Desipramineapproved, investigationalunknownsubstrateinhibitorDetails
DB01193Acebutololapproved, investigationalunknownsubstrateinhibitorDetails
DB01195Flecainideapproved, withdrawnunknownsubstrateinhibitorDetails
DB01228Encainideapproved, investigational, withdrawnunknownsubstrateDetails
DB01233Metoclopramideapproved, investigationalunknownsubstrateinhibitorDetails
DB01242Clomipramineapproved, investigational, vet_approvedunknownsubstrateinhibitorDetails
DB01171Moclobemideapproved, investigationalunknownsubstrateinhibitorDetails
DB01274Arformoterolapproved, investigationalunknownsubstrateDetails
DB01410Ciclesonideapproved, investigationalunknownsubstrateDetails
DB01466Ethylmorphineexperimental, illicitunknownsubstrateDetails
DB01409TiotropiumapprovednosubstrateDetails
DB01075Diphenhydramineapproved, investigationalunknownsubstrateinhibitorDetails
DB04840Debrisoquineapproved, investigationalunknownsubstrateDetails
DB00215CitalopramapprovednosubstrateinhibitorDetails
DB00234Reboxetineapproved, experimentalunknowninhibitorDetails
DB00257Clotrimazoleapproved, vet_approvedunknowninhibitorDetails
DB00317Gefitinibapproved, investigationalnosubstrateinhibitorDetails
DB00321AmitriptylineapprovedunknownsubstrateDetails
DB00342Terfenadineapproved, withdrawnunknownsubstrateinhibitorDetails
DB00343Diltiazemapproved, investigationalunknownsubstrateDetails
DB00356ChlorzoxazoneapprovedunknownsubstrateDetails
DB00363ClozapineapprovednosubstrateinhibitorDetails
DB00455Loratadineapproved, investigationalunknownsubstrateinhibitorDetails
DB00458ImipramineapprovedunknownsubstrateinhibitorDetails
DB00468QuinineapprovedunknownsubstrateinhibitorDetails
DB00482Celecoxibapproved, investigationalunknownsubstrateinhibitorDetails
DB00501Cimetidineapproved, investigationalunknowninhibitorDetails
DB00532Mephenytoinapproved, investigational, withdrawnunknownsubstrateDetails
DB00540NortriptylineapprovedunknownsubstrateinhibitorDetails
DB00613Amodiaquineapproved, investigationalunknowninhibitorDetails
DB00622Nicardipineapproved, investigationalunknowninhibitorDetails
DB00705DelavirdineapprovedunknownsubstrateinhibitorDetails
DB00726TrimipramineapprovedunknownsubstrateDetails
DB00752Tranylcypromineapproved, investigationalunknowninhibitorDetails
DB00857Terbinafineapproved, investigational, vet_approvedunknowninhibitorDetails
DB00908Quinidineapproved, investigationalunknowninhibitorDetails
DB00921Buprenorphineapproved, illicit, investigational, vet_approvedunknownsubstrateinhibitorDetails
DB00933Mesoridazineapproved, investigationalunknownsubstrateDetails
DB00972AzelastineapprovedunknownsubstrateinhibitorDetails
DB01026Ketoconazoleapproved, investigationalunknowninhibitorDetails
DB01071MequitazineexperimentalunknownsubstrateDetails
DB01104SertralineapprovedunknownsubstrateinhibitorDetails
DB01110Miconazoleapproved, investigational, vet_approvedunknowninhibitorDetails
DB01115NifedipineapprovedunknowninhibitorDetails
DB01118Amiodaroneapproved, investigationalnoinhibitorDetails
DB01131ProguanilapprovednoinhibitorDetails
DB01149Nefazodoneapproved, withdrawnunknownsubstrateinhibitorDetails
DB01156BupropionapprovedunknowninhibitorDetails
DB01175EscitalopramapprovednosubstrateinhibitorDetails
DB01182PropafenoneapprovedunknownsubstrateinhibitorDetails
DB01191Dexfenfluramineapproved, illicit, investigational, withdrawnunknownsubstrateinhibitorDetails
DB01192Oxymorphoneapproved, investigational, vet_approvedunknownsubstrateDetails
DB01218HalofantrineapprovedunknowninhibitorDetails
DB01238Aripiprazoleapproved, investigationalnosubstrateDetails
DB01403Methotrimeprazineapproved, investigationalunknownsubstrateinhibitorDetails
DB01551Dihydrocodeineapproved, illicitunknownsubstrateDetails
DB00377Palonosetronapproved, investigationalunknownsubstrateDetails
DB04861Nebivololapproved, investigationalunknownsubstrateDetails
DB04889BicifadineinvestigationalunknownsubstrateDetails
DB015621-(2-Phenylethyl)-4-phenyl-4-acetoxypiperidineexperimental, illicitunknowninhibitorDetails
DB06144Sertindoleapproved, investigational, withdrawnunknownsubstrateDetails
DB06148Mianserinapproved, investigationalunknownsubstrateDetails
DB04905TesmilifeneinvestigationalunknownsubstrateDetails
DB01624Zuclopenthixolapproved, investigationalunknownsubstrateDetails
DB00571Propranololapproved, investigationalunknownsubstrateinhibitorDetails
DB05271RotigotineapprovedunknownsubstrateinhibitorDetails
DB00472Fluoxetineapproved, vet_approvednosubstrateinhibitorDetails
DB01095FluvastatinapprovedunknownsubstrateDetails
DB01076AtorvastatinapprovednoinhibitorDetails
DB00439Cerivastatinapproved, withdrawnunknowninhibitorDetails
DB00619ImatinibapprovednosubstrateinhibitorDetails
DB00334Olanzapineapproved, investigationalnosubstrateinhibitorDetails
DB00792Tripelennamineapproved, vet_approvedunknowninhibitorDetails
DB00188Bortezomibapproved, investigationalunknownsubstrateDetails
DB05109Trabectedinapproved, investigationalunknownsubstrateDetails
DB00568Cinnarizineapproved, investigationalunknownsubstrateDetails
DB04841FlunarizineapprovedunknownsubstrateDetails
DB06726BufuralolexperimentalunknownsubstrateDetails
DB014724-Methoxyamphetamineexperimental, illicitunknownsubstrateDetails
DB03783PhenacetinwithdrawnunknownsubstrateDetails
DB06727Sparteineexperimental, withdrawnunknownsubstrateinhibitorDetails
DB00283Clemastineapproved, investigationalunknowninhibitorDetails
DB00907Cocaineapproved, illicitunknowninhibitorDetails
DB00997Doxorubicinapproved, investigationalnosubstrateinhibitorDetails
DB00333MethadoneapprovednosubstrateinhibitorDetails
DB01388Mibefradilinvestigational, withdrawnunknowninhibitorDetails
DB00211MidodrineapprovedunknownsubstrateDetails
DB00208TiclopidineapprovedunknownsubstrateinhibitorDetails
DB00543AmoxapineapprovedunknownsubstrateinhibitorDetails
DB00608Chloroquineapproved, investigational, vet_approvedunknownsubstrateinhibitorDetails
DB04946IloperidoneapprovedunknownsubstrateDetails
DB01577Metamfetamineapproved, illicit, withdrawnunknownsubstrateDetails
DB01621Pipotiazineapproved, investigationalunknownsubstrateinhibitorDetails
DB00706Tamsulosinapproved, investigationalunknownsubstrateDetails
DB04844Tetrabenazineapproved, investigationalunknownsubstrateDetails
DB01601LopinavirapprovedunknownsubstrateDetails
DB00932Tipranavirapproved, investigationalunknownsubstrateinhibitorDetails
DB04855DronedaroneapprovedunknownsubstrateinhibitorDetails
DB00951Isoniazidapproved, investigationalunknowninhibitorDetails
DB06708LumefantrineapprovedunknowninhibitorDetails
DB04868Nilotinibapproved, investigationalunknowninhibitorDetails
DB01424Aminophenazoneapproved, withdrawnunknownsubstrateDetails
DB00238NevirapineapprovedunknownsubstrateinhibitorDetails
DB00216Eletriptanapproved, investigationalunknownsubstrateDetails
DB00425ZolpidemapprovedunknownsubstrateDetails
DB01628Etoricoxibapproved, investigationalunknowninhibitorDetails
DB00203Sildenafilapproved, investigationalunknownsubstrateDetails
DB00316AcetaminophenapprovedunknownsubstrateDetails
DB00924CyclobenzaprineapprovedunknownsubstrateDetails
DB00381AmlodipineapprovedunknowninhibitorDetails
DB00701Amprenavirapproved, investigationalunknownsubstrateDetails
DB01429AprindineexperimentalunknownsubstrateDetails
DB00637Astemizoleapproved, withdrawnunknownsubstrateDetails
DB01244Bepridilapproved, withdrawnunknownsubstrateinhibitorDetails
DB00195Betaxololapproved, investigationalunknownsubstrateDetails
DB00810Biperidenapproved, investigationalunknowninhibitorDetails
DB00297Bupivacaineapproved, investigationalunknownsubstrateDetails
DB00490Buspironeapproved, investigationalunknownsubstrateDetails
DB00201CaffeineapprovedunknownsubstrateDetails
DB00091Cyclosporineapproved, investigational, vet_approvedunknowninhibitorDetails
DB00604Cisaprideapproved, investigational, withdrawnunknowninhibitorDetails
DB01093Dimethyl sulfoxideapproved, vet_approvedunknowninhibitorDetails
DB01184Domperidoneapproved, investigational, vet_approvedunknownsubstrateDetails
DB00590DoxazosinapprovedunknownsubstrateDetails
DB00625Efavirenzapproved, investigationalunknowninhibitorDetails
DB00751Epinastineapproved, investigationalunknownsubstrateinhibitorDetails
DB01023Felodipineapproved, investigationalunknowninhibitorDetails
DB01611HydroxychloroquineapprovedunknownsubstrateinhibitorDetails
DB01177IdarubicinapprovedunknownsubstrateDetails
DB00224IndinavirapprovedunknowninhibitorDetails
DB00598LabetalolapprovedunknownsubstrateinhibitorDetails
DB00448Lansoprazoleapproved, investigationalunknowninhibitorDetails
DB00528Lercanidipineapproved, investigationalunknowninhibitorDetails
DB01206Lomustineapproved, investigationalunknowninhibitorDetails
DB06691Mepyramineapproved, vet_approvedunknowninhibitorDetails
DB01028Methoxyfluraneapproved, investigational, vet_approved, withdrawnunknownsubstrateDetails
DB00834Mifepristoneapproved, investigationalunknowninhibitorDetails
DB00731Nateglinideapproved, investigationalunknownsubstrateDetails
DB00220NelfinavirapprovednoinhibitorDetails
DB02701Nicotinamideapproved, investigationalunknowninhibitorDetails
DB00184NicotineapprovedunknownsubstrateDetails
DB00627Niacinapproved, investigational, nutraceuticalunknowninhibitorDetails
DB00338Omeprazoleapproved, investigational, vet_approvedunknowninhibitorDetails
DB01096OxamniquineapprovedunknownsubstrateinhibitorDetails
DB01580OxprenololapprovedunknownsubstrateinhibitorDetails
DB01062Oxybutyninapproved, investigationalunknowninhibitorDetails
DB00738Pentamidineapproved, investigationalunknownsubstrateDetails
DB01435Antipyrineapproved, investigationalunknownsubstrateDetails
DB01100PimozideapprovednoinhibitorDetails
DB00592Piperazineapproved, vet_approvedunknownsubstrateDetails
DB01087PrimaquineapprovedunknowninhibitorDetails
DB00396Progesteroneapproved, vet_approvedunknownsubstrateDetails
DB01224QuetiapineapprovedunknownsubstrateDetails
DB00409Remoxiprideapproved, withdrawnunknownsubstrateDetails
DB00412Rosiglitazoneapproved, investigationalunknowninhibitorDetails
DB01232Saquinavirapproved, investigationalunknowninhibitorDetails
DB01037Selegilineapproved, investigational, vet_approvedunknownsubstrateinhibitorDetails
DB00641SimvastatinapprovedunknownsubstrateDetails
DB06729SulfaphenazoleapprovedunknowninhibitorDetails
DB01079Tegaserodapproved, investigational, withdrawnunknownsubstrateinhibitorDetails
DB00277TheophyllineapprovedunknownsubstrateDetails
DB00763MethimazoleapprovedunknowninhibitorDetails
DB01623ThiothixeneapprovedunknowninhibitorDetails
DB00209TrospiumapprovedunknowninhibitorDetails
DB00661VerapamilapprovedunknowninhibitorDetails
DB00570VinblastineapprovedunknowninhibitorDetails
DB00361Vinorelbineapproved, investigationalnoinhibitorDetails
DB01392Yohimbineapproved, investigational, vet_approvedunknownsubstrateDetails
DB06287TemsirolimusapprovedunknowninhibitorDetails
DB00398Sorafenibapproved, investigationalunknowninhibitorDetails
DB00530Erlotinibapproved, investigationalunknownsubstrateDetails
DB01128BicalutamideapprovedunknowninhibitorDetails
DB01129Rabeprazoleapproved, investigationalunknowninhibitorDetails
DB01166Cilostazolapproved, investigationalunknownsubstrateDetails
DB06216AsenapineapprovedunknownsubstrateinhibitorDetails
DB06589PazopanibapprovedunknowninhibitorDetails
DB06702FesoterodineapprovedunknownsubstrateDetails
DB06684VilazodoneapprovedunknownsubstrateDetails
DB00836LoperamideapprovedunknownsubstrateDetails
DB06506RepinotaninvestigationalunknownsubstrateDetails
DB06770Benzyl alcoholapprovedunknownsubstrateDetails
DB04920Clevidipineapproved, investigationalunknownsubstrateDetails
DB00633Dexmedetomidineapproved, vet_approvedunknowninhibitorDetails
DB06370IndisulaminvestigationalunknowninhibitorDetails
DB06735EnclomipheneinvestigationalunknownsubstrateDetails
DB06204TapentadolapprovedunknownsubstrateDetails
DB04871Lorcaserinapproved, withdrawnnosubstrateinhibitorDetails
DB05812AbirateroneapprovedunknowninhibitorDetails
DB08881VemurafenibapprovedunknowninhibitorDetails
DB08893MirabegronapprovednosubstrateinhibitorDetails
DB08901Ponatinibapproved, investigationalunknownsubstrateDetails
DB06203AlogliptinapprovedunknownsubstrateDetails
DB08918Levomilnacipranapproved, investigationalunknownsubstrateDetails
DB06292DapagliflozinapprovednosubstrateDetails
DB09039Eliglustatapproved, investigationalnosubstrateinhibitorDetails
DB09048Netupitantapproved, investigationalnosubstrateDetails
DB09049NaloxegolapprovedunknowninhibitorDetails
DB09076UmeclidiniumapprovednosubstrateDetails
DB09065CobicistatapprovednosubstrateinhibitorDetails
DB09068Vortioxetineapproved, investigationalnosubstrateDetails
DB06016Cariprazineapproved, investigationalnosubstrateinhibitorDetails
DB00349Clobazamapproved, illicitnoinhibitorDetails
DB09128Brexpiprazoleapproved, investigationalnosubstrateDetails
DB09291Rolapitantapproved, investigationalnoinhibitorDetails
DB06678EsmirtazapineinvestigationalunknownsubstrateDetails
DB06603Panobinostatapproved, investigationalnoinhibitorDetails
DB09570Ixazomibapproved, investigationalunknownsubstrateDetails
DB06412Oxymetholoneapproved, illicitunknowninhibitorDetails
DB09183DasabuvirapprovednosubstrateDetails
DB06512DeramciclaneinvestigationalunknowninhibitorDetails
DB00022Peginterferon alfa-2bapprovedunknowninhibitorDetails
DB00494Entacaponeapproved, investigationalunknowninhibitorDetails
DB04938Ospemifeneapproved, investigationalunknowninhibitorDetails
DB06820SulconazoleapprovedunknowninhibitorDetails
DB08909Glycerol phenylbutyrateapprovedunknowninhibitorDetails
DB00420Promazineapproved, vet_approvedunknownsubstrateDetails
DB09118StiripentolapprovedunknowninhibitorDetails
DB12332Rucaparibapproved, investigationalnosubstrateinhibitorDetails
DB09555Dexchlorpheniramine maleateapprovednosubstrateinhibitorDetails
DB12161Deutetrabenazineapproved, investigationalnosubstrateDetails
DB06217Vernakalantapproved, investigationalunknownsubstrateinhibitorDetails
DB06595Midostaurinapproved, investigationalunknowninhibitorDetails
DB11915Valbenazineapproved, investigationalnosubstrateDetails
DB13174RheinexperimentalunknowninhibitorDetails
DB11994Diacereinapproved, investigationalunknowninhibitorDetails
DB08922PerospironeexperimentalunknownsubstrateDetails
DB09167DosulepinapprovedunknownsubstrateinhibitorDetails
DB11614RupatadineapprovednosubstrateDetails
DB09238Manidipineapproved, investigationalunknowninhibitorDetails
DB13874Enasidenibapproved, investigationalunknownsubstrateinhibitorDetails
DB12070Letermovirapproved, investigationalnosubstrateDetails
DB09061Cannabidiolapproved, investigationalunknownsubstrateinhibitorDetails
DB11638Artenimolapproved, experimental, investigationalunknowninhibitorDetails
DB09195LorpiprazoleapprovednosubstrateDetails
DB09224MelperoneinvestigationalunknowninhibitorDetails
DB11642Pitolisantapproved, investigationalunknownsubstrateinhibitorDetails
DB11633Isavuconazoleapproved, investigationalunknowninhibitorDetails
DB11130Opiumapproved, illicitnosubstrateDetails
DB09053IbrutinibapprovednosubstrateDetails
DB11586Asunaprevirapproved, investigational, withdrawnnosubstrateinhibitorDetails
DB140105-methoxy-N,N-dimethyltryptamineexperimental, illicitunknownsubstrateDetails
DB13975Black cohoshexperimentalnoinhibitorDetails
DB14011NabiximolsinvestigationalunknownsubstrateDetails
DB14009Medical Cannabisexperimental, investigationalunknownsubstrateinhibitorDetails
DB13293Ipecacapproved, withdrawnnosubstrateDetails
DB04948Lofexidineapproved, investigationalnosubstrateDetails
DB11672Curcuminapproved, investigationalunknowninhibitorDetails
DB04829Lysergic acid diethylamideillicit, investigational, withdrawnnosubstrateDetails
DB14185Aripiprazole lauroxilapproved, investigationalunknownsubstrateDetails
DB11718Encorafenibapproved, investigationalnosubstrateinhibitorDetails
DB06608Tafenoquineapproved, investigationalnosubstrateDetails
DB11979Elagolixapproved, investigationalnosubstrateDetails
DB11785AnisodamineinvestigationalnosubstrateDetails
DB09204ArotinololinvestigationalnosubstrateDetails
DB00335AtenololapprovednosubstrateDetails
DB09013BefunololexperimentalnosubstrateDetails
DB01295BevantololexperimentalnosubstrateDetails
DB08807BopindololexperimentalnosubstrateDetails
DB12752BucindololinvestigationalnosubstrateDetails
DB08808BupranololexperimentalnosubstrateDetails
DB04846Celiprololapproved, investigationalnosubstrateDetails
DB13508CloranololexperimentalnosubstrateDetails
DB13757EpanololexperimentalnosubstrateDetails
DB13443EsatenololexperimentalnosubstrateDetails
DB00187Esmololapproved, withdrawnnosubstrateDetails
DB08952IndenololwithdrawnnosubstrateDetails
DB12212LandiololinvestigationalnosubstrateDetails
DB09351Levobetaxololapproved, investigationalnosubstrateDetails
DB01210LevobunololapprovednosubstrateDetails
DB13530MepindololexperimentalnosubstrateDetails
DB01214MetipranololapprovednosubstrateDetails
DB01359Penbutololapproved, investigationalnosubstrateDetails
DB01297PractololapprovednosubstrateDetails
DB00489SotalolapprovednosubstrateDetails
DB11770TalinololinvestigationalnosubstrateDetails
DB13775TertatololexperimentalnosubstrateDetails
DB00780PhenelzineapprovedunknowninhibitorDetails
DB06654Safinamideapproved, investigationalunknowninhibitorDetails
DB04818IproniazidwithdrawnunknowninhibitorDetails
DB01267PaliperidoneapprovedunknownsubstrateDetails
DB09078Lenvatinibapproved, investigationalunknowninhibitorDetails
DB08864RilpivirineapprovedunknowninhibitorDetails
DB04911Oritavancinapproved, investigationalunknowninhibitorinducerDetails
DB04884DapoxetineinvestigationalnosubstrateDetails
DB12693RitanserininvestigationalnoinhibitorDetails
DB02703Fusidic acidapproved, investigationalunknownsubstrateinhibitorDetails
DB09288PropacetamolexperimentalnosubstrateDetails
DB14635Curcumin sulfateexperimentalunknowninhibitorDetails
DB11963Dacomitinibapproved, investigationalunknownsubstrateinhibitorDetails
DB14025ClinafloxacininvestigationalunknowninhibitorDetails
DB01323St. John's Wortapproved, investigational, nutraceuticalnoinhibitorDetails
DB01454Midomafetamineexperimental, illicit, investigationalnosubstrateDetails
DB11855Revefenacinapproved, investigationalnosubstrateDetails
DB12245Triclabendazoleapproved, investigationalunknownsubstrateinhibitorDetails
DB01576Dextroamphetamineapproved, illicitnosubstrateDetails
DB06700Desvenlafaxineapproved, investigationalnoinhibitorDetails
DB00737MeclizineapprovednosubstrateDetails
DB01591SolifenacinapprovedunknownsubstrateDetails
DB13679Dexchlorpheniramineexperimental, investigationalunknownsubstrateinhibitorDetails
DB12523Mizolastineapproved, investigationalunknowninhibitorDetails
DB01173OrphenadrineapprovedunknowninhibitorDetails
DB09173ButyrfentanylillicitunknownsubstrateDetails
DB11757Istradefyllineapproved, investigationalunknownsubstrateDetails
DB04957AzimilideinvestigationalunknownsubstrateDetails
DB09061Cannabidiolapproved, investigationalunknowninhibitorDetails
DB14011NabiximolsinvestigationalunknownsubstrateinhibitorDetails
DB01590EverolimusapprovedunknowninhibitorDetails
DB12001Abemaciclibapproved, investigationalunknowninhibitorDetails
DB11732Lasmiditanapproved, investigationalnoinhibitorDetails
DB15444Elexacaftorapproved, investigationalnoinhibitorDetails
DB15091Upadacitinibapproved, investigationalunknownsubstrateDetails
DB00252Phenytoinapproved, vet_approvednosubstrateDetails
DB15328Ubrogepantapproved, investigationalunknowninhibitorDetails
DB00983Formoterolapproved, investigationalunknownsubstrateDetails
DB01264DarunavirapprovedunknowninhibitorDetails
DB13609UmifenovirinvestigationalunknownsubstrateDetails
DB11837Osilodrostatapproved, investigationalunknownsubstrateinhibitorDetails
DB12500Fedratinibapproved, investigationalunknowninhibitorDetails
DB09241Methylene blueapproved, investigationalunknownsubstrateinhibitorDetails
DB14761Remdesivirapproved, investigationalunknownsubstrateDetails
DB14840RipretinibapprovedunknownsubstrateDetails
DB00845Clofazimineapproved, investigationalunknowninhibitorDetails
DB14881Oliceridineapproved, investigationalunknownsubstrateDetails
DB12499Clascoteroneapproved, investigationalnoinhibitorDetails
DB15822Pralsetinibapproved, investigationalnosubstrateDetails
DB15982BerotralstatapprovednoinhibitorDetails
DB04951Pirfenidoneapproved, investigationalunknownsubstrateinhibitorDetails
DB06137Tirbanibulinapproved, investigationalnoinhibitorDetails
DB00549Zafirlukastapproved, investigationalunknowninhibitorDetails
DB00170Menadioneapproved, nutraceuticalunknowninhibitorDetails
DB00745Modafinilapproved, investigationalunknowninducerDetails
DB00330EthambutolapprovedunknowninhibitorDetails
DB01086Benzocaineapproved, investigationalunknownsubstrateDetails
DB05316Pimavanserinapproved, investigationalunknownsubstrateDetails
DB11753Rifamycinapproved, investigationalunknowninhibitorDetails
DB00986Glycopyrroniumapproved, investigational, vet_approvedunknownsubstrateDetails
DB15119Ropeginterferon alfa-2bapproved, investigationalnoinhibitorDetails
DB12151Brincidofovirapproved, investigationalnoinhibitorDetails
DB16703Belumosudilapproved, investigationalnosubstrateinhibitorDetails
DB12265Fexinidazoleapproved, investigationalunknownsubstrateinhibitorDetails
DB00602Ivermectinapproved, investigational, vet_approvednosubstrateDetails
DB12713Sotagliflozinapproved, investigationalnoinhibitorDetails
DB04216Quercetinexperimental, investigationalnoinhibitorDetails
DB00470Dronabinolapproved, illicitnoinhibitorDetails
DB14737Cannabinolexperimental, investigationalunknowninhibitorDetails
DB05087Ganaxoloneapproved, investigationalnosubstrateDetails
DB09185Viloxazineapproved, investigational, withdrawnnosubstrateinhibitorDetails
DB14921Mavacamtenapproved, investigationalnoDetails
DB06083Tapinarofapproved, investigationalnosubstrateDetails
DB16650Deucravacitinibapproved, investigationalunknownsubstrateDetails
DB12095Telotristat ethylapproved, investigationalnoinhibitorDetails
DB15149Futibatinibapproved, investigationalnosubstrateDetails
DB11739Vonoprazanapproved, investigationalunknownsubstrateDetails
DB05239Cobimetinibapproved, investigationalnoinhibitorDetails
DB02709ResveratrolinvestigationalnoinhibitorDetails
DB15568Adagrasibapproved, investigationalunknownsubstrateinhibitorDetails
DB12236Bexagliflozinapproved, investigationalunknownsubstrateDetails
DB17472Pirtobrutinibapproved, investigationalunknowninhibitorDetails
DB15688Zavegepantapproved, investigationalunknownsubstrateDetails
DB00862VardenafilapprovedunknowninhibitorDetails
DB16217Leniolisibapproved, investigationalnosubstrateDetails
DB00953RizatriptanapprovednoinhibitorDetails
DB11712Tezacaftorapproved, investigationalnoinhibitorDetails
DB12005Nirogacestatapproved, investigationalnosubstrateDetails
DB16200Iptacopanapproved, investigationalnosubstrateDetails
DB06636Isavuconazoniumapproved, investigationalnoinhibitorDetails