Flavin reductase (NADPH)

BE0000595ProteinHumansBLVRB

Enzyme that can both act as a NAD(P)H-dependent reductase and a S-nitroso-CoA-dependent nitrosyltransferase (PubMed:10620517, PubMed:18241201, PubMed:27207795, PubMed:38056462, PubMed:7929092). It is acted on by 8 drugs in DrugBank.

Gene name
BLVRB
UniProtKB entry
P30043Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
206 residues · 22,119 Da
Also known as
1.5.1.30 · Biliverdin reductase B · Biliverdin-IX beta-reductase · BVR-B · FLR

Resolves to

Protein
UniProtP30043UniProt nameBLVRB_HUMAN
Gene
HGNCHGNC:1063NCBI Gene645GenBank1384068GeneCardsBLVRB
Pharmacology
KEGGhsa:645
Structure
PDB1HDOPDB1HE2PDB1HE3
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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29+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Flavin reductase (NADPH), how selective are they, and which programs against it are still in active trials?

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