C-1-tetrahydrofolate synthase, cytoplasmic

BE0000617ProteinHumansMTHFD1

Trifunctional enzyme that catalyzes the interconversion of three forms of one-carbon-substituted tetrahydrofolate: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate, 5,10-methenyltetrahydrofolate and (6S)-10-formyltetrahydrofolate (PubMed:10828945, PubMed:18767138, PubMed:1881876). It is acted on by 5 drugs in DrugBank.

Gene name
MTHFD1
UniProtKB entry
P11586Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
935 residues · 101,530 Da
Also known as
C1-THF synthase · Epididymis secretory sperm binding protein · MTHFC · MTHFD

Resolves to

Protein
UniProtP11586UniProt nameC1TC_HUMAN
Gene
HGNCHGNC:7432NCBI Gene4522GenBank307178GeneCardsMTHFD1
Pharmacology
KEGGhsa:4522
Structure
PDB1A4IPDB1DIAPDB1DIB
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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19GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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33+ReferencesStructured and connected to the statements they support
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Which approved drugs act on C-1-tetrahydrofolate synthase, cytoplasmic, how selective are they, and which programs against it are still in active trials?

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