Glutamate receptor ionotropic, kainate 2

BE0000826ProteinHumansGRIK2

Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid (PubMed:7536611, PubMed:8730589, PubMed:14511640). It is acted on by 21 drugs in DrugBank.

Gene name
GRIK2
UniProtKB entry
Q13002Swiss-Prot
Cellular location
Cell membrane
Residues / weight
908 residues · 102,582 Da
Also known as
EAA4 · Excitatory amino acid receptor 4 · GluK2 · GluR-6 · GLUR6

Resolves to

Protein
UniProtQ13002UniProt nameGRIK2_HUMAN
Gene
HGNCHGNC:4580NCBI Gene2898GenBank790532GeneCardsGRIK2
Pharmacology
IUPHAR/GtoPdb451KEGGhsa:2898
Structure
PDB3QXMPDB5CMM
Drugs

What you can answer from here — as of September 07, 2019

21DrugsApproved to experimental, with action, bond type and pharmacological action
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23GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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52+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glutamate receptor ionotropic, kainate 2, how selective are they, and which programs against it are still in active trials?

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