Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

BE0001315ProteinHumansPIK3CG

Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). It is acted on by 47 drugs in DrugBank.

Gene name
PIK3CG
UniProtKB entry
P48736Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
1,102 residues · 126,453 Da
Also known as
2.7.1.137 · 2.7.1.153 · 2.7.1.154 · p110gamma · p120-PI3K

Resolves to

Protein
UniProtP48736UniProt namePK3CG_HUMAN
Gene
HGNCHGNC:8978NCBI Gene5294GenBank1507822GeneCardsPIK3CG
Pharmacology
IUPHAR/GtoPdb2156KEGGhsa:5294
Structure
PDB1E8YPDB1E8ZPDB1HE8
Drugs

What you can answer from here — as of September 07, 2019

47DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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17GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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144+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, how selective are they, and which programs against it are still in active trials?

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