Histone deacetylase 8

BE0001608ProteinHumansHDAC8

Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:10748112, PubMed:10922473, PubMed:10926844, PubMed:14701748, PubMed:28497810). It is acted on by 21 drugs in DrugBank.

Gene name
HDAC8
UniProtKB entry
Q9BY41Swiss-Prot
Cellular location
Nucleus
Residues / weight
377 residues · 41,757 Da
Also known as
3.5.1.98 · HD8 · HDACL1 · Protein deacetylase HDAC8 · Protein decrotonylase HDAC8

Resolves to

Protein
UniProtQ9BY41UniProt nameHDAC8_HUMAN
Gene
HGNCHGNC:13315NCBI Gene55869GenBank8118721GeneCardsHDAC8
Pharmacology
IUPHAR/GtoPdb2619KEGGhsa:55869
Structure
PDB1T64PDB1T67PDB1T69
Drugs

What you can answer from here — as of September 07, 2019

21DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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49+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Histone deacetylase 8, how selective are they, and which programs against it are still in active trials?

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