Phospholipase A2, membrane associated

BE0001640ProteinHumansPLA2G2A

Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids with implications in host antimicrobial defense, inflammatory response and tissue regeneration (PubMed:10455175, PubMed:10681567, PubMed:2925633). It is acted on by 21 drugs in DrugBank.

Gene name
PLA2G2A
UniProtKB entry
P14555Swiss-Prot
Cellular location
Secreted
Residues / weight
144 residues · 16,083 Da
Also known as
3.1.1.4 · GIIC sPLA2 · Group IIA phospholipase A2 · Non-pancreatic secretory phospholipase A2 · NPS-PLA2

Resolves to

Protein
UniProtP14555UniProt namePA2GA_HUMAN
Gene
HGNCHGNC:9031NCBI Gene5320GenBank190889GeneCardsPLA2G2A
Pharmacology
IUPHAR/GtoPdb1417KEGGhsa:5320
Structure
PDB1AYPPDB1BBCPDB1DB4
Drugs

What you can answer from here — as of September 07, 2019

21DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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56+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Phospholipase A2, membrane associated, how selective are they, and which programs against it are still in active trials?

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