Glutamine synthetase

BE0002240ProteinHumansGLUL

Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (PubMed:16267323, PubMed:30158707, PubMed:36289327). It is acted on by 12 drugs in DrugBank.

Gene name
GLUL
UniProtKB entry
P15104Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
373 residues · 42,064 Da
Also known as
6.3.1.2 · GLNS · Glutamate--ammonia ligase · GS · Palmitoyltransferase GLUL

Resolves to

Protein
UniProtP15104UniProt nameGLNA_HUMAN
Gene
HGNCHGNC:4341NCBI Gene2752GenBank31833GeneCardsGLUL
Pharmacology
KEGGhsa:2752
Structure
PDB2OJWPDB2QC8PDB7EVT
Drugs

What you can answer from here — as of September 07, 2019

12DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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39+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glutamine synthetase, how selective are they, and which programs against it are still in active trials?

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