Peptidoglycan D,D-transpeptidase FtsI

BE0002393ProteinEscherichia coli (strain K12)ftsI

Essential cell division protein that catalyzes cross-linking of the peptidoglycan cell wall at the division septum (PubMed:1103132, PubMed:3531167, PubMed:6450748, PubMed:7030331, PubMed:9614966). It is acted on by 23 drugs in DrugBank.

Gene name
ftsI
UniProtKB entry
P0AD68Swiss-Prot
Cellular location
Cell inner membrane
Residues / weight
588 residues · 63,877 Da
Also known as
2.4.1.129 · 3.4.16.4 · Essential cell division protein FtsI · Murein transpeptidase · PBP-3

Resolves to

Protein
UniProtP0AD68UniProt nameFTSI_ECOLI
Gene
NCBI Gene944799
Pharmacology
KEGGecj:JW0082
Drugs

What you can answer from here — as of May 03, 2025

23DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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57+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Peptidoglycan D,D-transpeptidase FtsI, how selective are they, and which programs against it are still in active trials?

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