Pagoclone is an anxiolytic drug from the cyclopyrrolone family, which is related to other more well known drugs such as the sleeping medication zopiclone. It is one of a relatively... It is one of a relatively recently developed class of medicines known as the nonbenzodiazepines, which have similar effects to the older benzodiazepine group, but with quite different chemical structures.
- Mechanism
- Curator reviewed
Pagoclone is a subtype-selective drug which binds primarily to the alpha2/alpha3 subtypes of the GABAA receptor which are responsible for the anti-anxiety effects of these kind of drugs, but has relatively little efficacy at the alpha1 subtype which produces the sedative and memory loss effects.
- Primary indication
- For the potential treatment of panic and anxiety disorders.Curator reviewed
- Formula / weight
- C23H22ClN3O2 · 407.893 g/mol (avg)
Resolves to
HIUPRQPBWVEQJJ-UHFFFAOYSA-NSMILESCC(C)CCC(=O)CC1N(C(=O)C2=CC=CC=C12)C1=NC2=C(C=CC(Cl)=N2)C=C1What you can answer from here — as of January 29, 2025
Which drugs share a target with Pagoclone, and which of those have an active Phase 3 trial?
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