- Hypothalamic Hormones
- Accession Number
Peptide hormones produced by NEURONS of various regions in the HYPOTHALAMUS. They are released into the pituitary portal circulation to stimulate or inhibit PITUITARY GLAND functions. VASOPRESSIN and OXYTOCIN, though produced in the hypothalamus, are not included here for they are transported down the AXONS to the POSTERIOR LOBE OF PITUITARY before being released into the portal circulation.
- ATC Classification
Drug Drug Description Gonadorelin A synthetic GnRH used to test the function of gonadotropes and the pituitary. Nafarelin A gonadotropin releasing hormone agonist used to treat central precocious puberty. Somatostatin A naturally-occurring peptide hormone used for the symptomatic treatment of acute bleeding from esophageal varices. Cetrorelix A synthetic peptide antagonist of gonadotropin releasing hormone used to prevent luteinizing hormone surges in women undergoing assisted reproduction therapy. Vapreotide For the treatment of esophageal variceal bleeding in patients with cirrhotic liver disease and has also shown efficacy in the treatment of patients with AIDS-related diarrhea. Pasireotide A somatostatin analog used in the treatment of Cushing’s disease, specifically for those patients whom pituitary surgery is not appropriate. Ganirelix A GnRH antagonist used in assisted reproduction in women undergoing controlled ovarian hyperstimulation to control ovulation by inhibiting the premature LH surges. Lanreotide A somatostatin analog used for the treatment of unresectable, well- or moderately-differentiated, locally advanced or metastatic gastroenteropancreatic neuroendocrine tumors and acromegaly. Leuprolide A peptide-based GnRH receptor superagonist used for the palliative treatment of prostate cancer, uterine leiomyomata, endometriosis, and central precocious puberty. Sermorelin For the treatment of dwarfism, prevention of HIV-induced weight loss Goserelin A synthetic analog of luteinizing hormone-releasing hormone used to treat breast cancer and prostate cancer by reducing secretion of gonadotropins from the pituitary. Corticorelin Investigated for use/treatment in brain cancer and neurologic disorders. Buserelin A LHRH agonist used for the palliative treatment of hormone-dependent advanced carcinoma of the prostate gland in males and treatment of endometriosis in females. Histrelin A GnRH agonist found in subcutaneous implants used for the treatment of pediatric patients with central precocious puberty and the palliative treatment of advanced prostate cancer. Triptorelin A GnRH agonist indicated for the palliative treatment of advanced prostate cancer. Tesamorelin A growth hormone releasing factor (GRF) analog used to reduce excessive abdominal fat in HIV patients who have developed lipodystrophy. Corticorelin ovine triflutate A synthetic corticotropin-releasing hormone used for diagnostic purposes in differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushing's syndrome. Protirelin A synthetic analogue of thyrotropin-releasing hormone that has been used during diagnostic tests to evaluate function of the thyroid gland. Deslorelin Deslorelin acetate is an injectable gonadotropin releasing hormone super-agonist also known as an LHRH agonist. It stops the production of sex hormones. TT-232 Tln 232 is under investigation in clinical trial NCT00422786 (Phase II Study of CAP-232 in Patients With Refractory Metastatic Renal Cell Carcinoma). Pentetreotide Pentetreotide has been used in trials studying the diagnostic of cushing syndrome. Zoptarelin doxorubicin Zoptarelin doxorubicin has been used in trials studying the treatment of Breast Cancer, Ovarian Cancer, Prostate Cancer, Endometrial Cancer, and Urothelial Carcinoma, among others. Somatoprim Somatoprim is under investigation for the treatment of Acromegaly. Alsactide Not Annotated Octreotide A peptide drug used to treat acromegaly as well as diarrhea associated with metastatic carcinoid tumors and vasoactive intestinal peptide secreting tumors. Bremelanotide Bremelanotide is indicated to treat premenopausal women with hypoactive sexual desire disorder that is not due to a medical or psychiatric condition, problems with the relationship, or the effects of... Setmelanotide Setmelanotide is indicated to treat obesity caused by genetic POMC, PCSK1, or LEPR deficiencies. Indium In-111 pentetreotide Indium In 111 pentetreotide (Octreoscan) has been used in trials studying the diagnostic of SARCOIDOSIS, Solid Tumors, and cushing syndrome. Elagolix A gonadotropin releasing hormone receptor antagonist used to treat moderate to severe pain in endometriosis. Dopastatin Dopastatin is under investigation in clinical trial NCT04335357 (TBR-760 in Adult Patients With Non-functioning Pituitary Adenomas).
- Drugs & Drug Targets