Hypothalamic Hormones

Name
Hypothalamic Hormones
Accession Number
DBCAT000054
Description

Peptide hormones produced by NEURONS of various regions in the HYPOTHALAMUS. They are released into the pituitary portal circulation to stimulate or inhibit PITUITARY GLAND functions. VASOPRESSIN and OXYTOCIN, though produced in the hypothalamus, are not included here for they are transported down the AXONS to the POSTERIOR LOBE OF PITUITARY before being released into the portal circulation.

ATC Classification
Drugs
DrugDrug Description
GonadorelinA synthetic GnRH used to test the function of gonadotropes and the pituitary.
NafarelinA gonadotropin releasing hormone agonist used to treat central precocious puberty.
SomatostatinA naturally-occurring peptide hormone used for the symptomatic treatment of acute bleeding from esophageal varices.
CetrorelixA synthetic peptide antagonist of gonadotropin releasing hormone used to prevent luteinizing hormone surges in women undergoing assisted reproduction therapy.
VapreotideFor the treatment of esophageal variceal bleeding in patients with cirrhotic liver disease and has also shown efficacy in the treatment of patients with AIDS-related diarrhea.
PasireotideA somatostatin analog used in the treatment of Cushing’s disease, specifically for those patients whom pituitary surgery is not appropriate.
GanirelixA GnRH antagonist used in assisted reproduction in women undergoing controlled ovarian hyperstimulation to control ovulation by inhibiting the premature LH surges.
LanreotideA somatostatin analog used for the treatment of unresectable, well- or moderately-differentiated, locally advanced or metastatic gastroenteropancreatic neuroendocrine tumors and acromegaly.
LeuprolideA peptide-based GnRH receptor superagonist used for the palliative treatment of prostate cancer, uterine leiomyomata, endometriosis, and central precocious puberty.
SermorelinFor the treatment of dwarfism, prevention of HIV-induced weight loss
GoserelinA synthetic analog of luteinizing hormone-releasing hormone used to treat breast cancer and prostate cancer by reducing secretion of gonadotropins from the pituitary.
CorticorelinInvestigated for use/treatment in brain cancer and neurologic disorders.
BuserelinA LHRH agonist used for the palliative treatment of hormone-dependent advanced carcinoma of the prostate gland in males and treatment of endometriosis in females.
HistrelinA GnRH agonist found in subcutaneous implants used for the treatment of pediatric patients with central precocious puberty and the palliative treatment of advanced prostate cancer.
TriptorelinA GnRH agonist indicated for the palliative treatment of advanced prostate cancer.
TesamorelinA growth hormone releasing factor (GRF) analog used to reduce excessive abdominal fat in HIV patients who have developed lipodystrophy.
Corticorelin ovine triflutateA synthetic corticotropin-releasing hormone used for diagnostic purposes in differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushing's syndrome.
ProtirelinA synthetic analogue of thyrotropin-releasing hormone that has been used during diagnostic tests to evaluate function of the thyroid gland.
DeslorelinDeslorelin acetate is an injectable gonadotropin releasing hormone super-agonist also known as an LHRH agonist. It stops the production of sex hormones.
TT-232Tln 232 is under investigation in clinical trial NCT00422786 (Phase II Study of CAP-232 in Patients With Refractory Metastatic Renal Cell Carcinoma).
PentetreotidePentetreotide has been used in trials studying the diagnostic of cushing syndrome.
Zoptarelin doxorubicinZoptarelin doxorubicin has been used in trials studying the treatment of Breast Cancer, Ovarian Cancer, Prostate Cancer, Endometrial Cancer, and Urothelial Carcinoma, among others.
SomatoprimSomatoprim is under investigation for the treatment of Acromegaly.
AlsactideNot Annotated
OctreotideA peptide drug used to treat acromegaly as well as diarrhea associated with metastatic carcinoid tumors and vasoactive intestinal peptide secreting tumors.
BremelanotideBremelanotide is indicated to treat premenopausal women with hypoactive sexual desire disorder that is not due to a medical or psychiatric condition, problems with the relationship, or the effects of...
SetmelanotideSetmelanotide has been investigated for the treatment of obesity.
Indium In-111 pentetreotideIndium In 111 pentetreotide (Octreoscan) has been used in trials studying the diagnostic of SARCOIDOSIS, Solid Tumors, and cushing syndrome.
ElagolixA gonadotropin releasing hormone receptor antagonist used to treat moderate to severe pain in endometriosis.
Drugs & Drug Targets
DrugTargetType
GonadorelinGonadotropin-releasing hormone receptortarget
GonadorelinPutative gonadotropin-releasing hormone II receptortarget
NafarelinGonadotropin-releasing hormone receptortarget
NafarelinPutative gonadotropin-releasing hormone II receptortarget
SomatostatinSomatostatin receptor type 1target
SomatostatinSomatostatin receptor type 2target
SomatostatinSomatostatin receptor type 3target
SomatostatinSomatostatin receptor type 4target
SomatostatinSomatostatin receptor type 5target
SomatostatinP-glycoprotein 1transporter
SomatostatinCytochrome P450 3A4enzyme
CetrorelixLutropin-choriogonadotropic hormone receptortarget
CetrorelixGonadotropin-releasing hormone receptortarget
VapreotideNeurokinin 1 receptortarget
VapreotideSomatostatin receptor type 2target
VapreotideSomatostatin receptor type 5target
VapreotideCytochrome P450 3A4enzyme
PasireotideSomatostatin receptor type 1target
PasireotideSomatostatin receptor type 2target
PasireotideSomatostatin receptor type 3target
PasireotideSomatostatin receptor type 5target
PasireotideCytochrome P450 3A4enzyme
GanirelixGonadotropin-releasing hormone receptortarget
LanreotideSomatostatin receptor type 2target
LanreotideSomatostatin receptor type 5target
LanreotideCytochrome P450 3A4enzyme
LeuprolideGonadotropin-releasing hormone receptortarget
SermorelinGrowth hormone-releasing hormone receptortarget
GoserelinLutropin-choriogonadotropic hormone receptortarget
GoserelinGonadotropin-releasing hormone receptortarget
CorticorelinDopamine beta-hydroxylaseenzyme
BuserelinLutropin-choriogonadotropic hormone receptortarget
BuserelinGonadotropin-releasing hormone receptortarget
BuserelinCytochrome P450 19A1enzyme
HistrelinGonadotropin-releasing hormone receptortarget
TriptorelinGonadotropin-releasing hormone receptortarget
TesamorelinGrowth hormone-releasing hormone receptortarget
Corticorelin ovine triflutateCorticotropin-releasing factor receptor 1target
ProtirelinThyrotropin Releasing Hormone Receptortarget
OctreotideMyeloperoxidaseenzyme
OctreotideCytochrome P450 3A4enzyme
OctreotideSomatostatin receptortarget
OctreotideSerum albumincarrier
OctreotideP-glycoprotein 1transporter
OctreotideCanalicular multispecific organic anion transporter 1transporter
BremelanotideMelanocyte-stimulating hormone receptortarget
BremelanotideMelanocortin receptor 4target
BremelanotideMelanocortin receptor 3target
BremelanotideMelanocortin receptor 5target
BremelanotideAdrenocorticotropic hormone receptortarget
ElagolixGonadotropin-releasing hormone receptortarget
ElagolixCytochrome P450 3A Subfamilyenzyme
ElagolixCytochrome P450 2D6enzyme
ElagolixCytochrome P450 2C8enzyme
ElagolixP-glycoprotein 1transporter
ElagolixSolute carrier organic anion transporter family member 1B1transporter