Dopastatin

DB16144InvestigationalSmall molecule

Dopastatin is under investigation in clinical trial NCT04335357 (TBR-760 in Adult Patients With Non-functioning Pituitary Adenomas).

Mechanism: Pharmacologically active on Somatostatin receptor type 5, Somatostatin receptor type 2, and Dopamine receptor D2
Curator reviewed
Formula / weight: C₈₆H₁₁₆N₁₆O₁₂S₄ · 1694.21 g/mol (avg)
Also known as: Onzigolide
Code names: BIM-23A760 · TBR-760

Resolves to

Compound

UNIIL32IM11DV4CAS868562-36-1

Structure

InChIKeyWLBJBODHTIKYSL-RXHQQAJBSA-NSMILES

[H][C@@]12CC3=CNC4=C3C(=CC=C4)[C@@]1([H])C[C@@H](CSCC(=O)NCCCC[C@@H](NC(=O)CSC[C@H]1CN(CCC)[C@]3([H])CC4=CNC5=C4C(=CC=C5)[C@@]3([H])C1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CC)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC3=CNC4=C3C=CC=C4)NC(=O)[C@H](CC3=CC=C(O)C=C3)NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O)CN2CCC

Targets

P35346SSTR5P30874SSTR2P14416DRD2P09917ALOX5

What you can answer from here — as of June 15, 2026

4Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

3Clinical trialsPhase, status and sponsor resolved per trial

9+ReferencesStructured and connected to the statements they support

Which drugs share a target with Dopastatin, and which of those have an active Phase 3 trial?

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