Ribonucleosides

Name
Ribonucleosides
Accession Number
DBCAT000258
Description

Nucleosides in which the purine or pyrimidine base is combined with ribose. (Dorland, 28th ed)

Drugs
DrugDrug Description
VidarabineAn antiviral agent used to treat various viral infections.
CladribineA purine antimetabolite used for the management of relapsing forms of Multiple Sclerosis (MS), used in patients who have not responded to or who were unable to tolerate alternative MS drugs.
GemcitabineA nucleoside metabolic inhibitor used as adjunct therapy in the treatment of certain types of ovarian cancer, non-small cell lung carcinoma, metastatic breast cancer, and as a single agent for pancreatic cancer.
AdenosineA medication used in myocardial perfusion scintigraphy and to treat supraventricular tachycardia.
RibavirinA guanosine nucleoside used to treat some forms of Hepatitis C.
EmtricitabineA nucleoside reverse transcriptase inhibitor used for the treatment and prophylaxis of HIV.
DecitabineA chemotherapeutic pyrimidine nucleoside analogue used for the treatment of myelodysplastic syndromes (MDS) by inducing DNA hypomethylation and corresponding alterations in gene expression.
UridineA drug used to manage neuropsychiatric deficits associated with cerebrovascular diseases in combination with cytidine.
TicagrelorA P2Y12 platelet inhibitor used in patients with a history of myocardial infarction or with acute coronary syndrome (ACS) to prevent future myocardial infarction, stroke and cardiovascular death.
Toyocamycin4-Amino-5-cyano-7-(D-ribofuranosyl)-7H- pyrrolo(2,3-d)pyrimidine. Antibiotic antimetabolite isolated from Streptomyces toyocaensis cultures. It is an analog of adenosine, blocks RNA synthesis and ribosome function, and is used mainly as a tool in biochemistry.
DichlororibofuranosylbenzimidazoleNot Available
N4-HydroxycytidineA cytidine analog being investigated to treat COVID-19.
CytidineA drug used to manage neuropsychiatric deficits associated with cerebrovascular diseases in combination with uridine.
GuanosineGuanosine is a nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine can be phosphorylated to become GMP (guanosine monophosphate), cGMP (cyclic guanosine monophosphate), GDP...
TubercidinAn antibiotic purine ribonucleoside that readily substitutes for adenosine in the biological system, but its incorporation into DNA and RNA has an inhibitory effect on the metabolism of these nucleic...
InosineA nutritional supplement touted to improve athletic performance and a drug used in vitro as a red blood cell rejuvenator for a unit of red blood cells that will be used in a clinical setting.
AdemetionineS-Adenosylmethionine (SAMe) is used as a drug in Europe for the treatment of depression, liver disorders, fibromyalgia, and osteoarthritis. It has also been introduced into the United States market as...
DidanosineA reverse transcriptase inhibitor used to treat HIV.
AzacitidineA pyrimidine nucleoside analogue used to treat certain subtypes of myelodysplastic syndrome.
5-fluorouridine5-fluorouridine is also known as FUrd, 5-Fluorouracil 1-beta-D-ribofuranoside, 5-Fur, or 5-Fluoro-uridine. 5-fluorouridine is a solid. This compound belongs to the pyrimidine nucleosides and analogues. These are compounds comprising a pyrimidine...
S-adenosyl-L-homocysteine5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine. Formed from S-adenosylmethionine after transmethylation reactions.
SinefunginSinefungin is a solid. This compound belongs to the purine nucleosides and analogues. These are compounds comprising a purine base attached to a sugar. The proteins that adenosyl-ornithine target include...
FormycinNot Available
DeoxyinosineNot Available
8-hydroxy-2'-deoxyguanosineNot Available
9-deazainosineNot Available
S-Adenosyl-1,8-Diamino-3-ThiooctaneNot Available
MethylthioinosineAn analog of inosine with a methylthio group replacing the hydroxyl group in the 6-position.
ZebularineA chemically stable, cytidine analog that displays anti-tumor properties. It acts as a transition state analog inhibitor of cytidine deaminase by binding to the active site as covalent hydrates. Also...
Deoxycytidylyl-3',5'-guanosineNot Available
5'-O-(N-(Alanyl)sulfamoyl)adenosineNot Available
7-MethylguanosineNot Available
Formycin BNot Available
3-DeazacytidineNot Available
2-FluoroadenosineNot Available
3-DeazaadenosineNot Available
5-iodotubercidinNot Available
CyclouridineNot Available
BinodenosonFor cardiac pharmacologic stress SPECT imaging, which is used to diagnose coronary artery disease.
IsatoribineFor the treatment of Hepatitis C.
TecadenosonInvestigated for use/treatment in arrhythmia and atrial fibrillation.
DenufosolFor use as an inhaled treatment for cystic fibrosis.
PiclidenosonInvestigated for use/treatment in cancer/tumors (unspecified), eye disorders/infections, psoriasis and psoriatic disorders, and rheumatoid arthritis. Can-Fite BioPharma has reported that by targeting the adenosine A3-receptor, CF101 may also be used...
TaribavirinInvestigated for use/treatment in hepatitis (viral, C).
TAS-106Investigated for use/treatment in solid tumors and cancer/tumors (unspecified).
N(6)-dimethylallyladenineNot Available
SofosbuvirA direct-acting antiviral agent used to treat specific hepatitis C virus (HCV) infections in combination with other antiviral agents.
Uridine triacetateA pyrimidine analog used for the reversal of overdose, regardless of the presence of symptoms, and early-onset, severe or life-threatening CNS toxicity or cardiotoxicity of fluorouracil or capecitabine.
GalidesivirGalidesivir is an adenosine analogue that has been investigated for use against Zaire Ebolavirus. In animal studies, galidesivir was effective in increasing the survival rates from infections caused by various...
GuadecitabineGuadecitabine is under investigation for the treatment of Previously Treated Metastatic Colorectal Cancer.
SonedenosonSonedenoson has been used in trials studying the treatment of Foot Ulcer, Diabetic and Diabetes Complications.
TetrahydrouridineTetrahydrouridine has been used in trials studying the treatment of Neoplasms, Lung Neoplasms, Breast Neoplasms, Sickle Cell Disease, and Head and Neck Cancer, among others.
UK-432097UK-432,097 has been used in trials studying the treatment of Pulmonary Disease, Chronic Obstructive.
TrabodenosonTrabodenoson has been used in trials studying the treatment of Ocular Hypertension (OHT) and Primary Open-Angle Glaucoma (POAG).
Inosine pranobexA medication used to treat subacute sclerosing panencephalitis.
TiazofurineTiazofurine has potential clinical use in cancer treatment as it is a potential inhibitor of Inosine- 5’-monophosphate (IMP) dehydrogenase .
2'-C-methylcytidineA nucleoside analog with anti-hepatitis C virus (HCV) activity. Upon phosphorylation into its 5-triphosphate form, this metabolite inhibits viral RNA chain elongation and viral RNA-dependent RNA polymerase activity. This blocks...
AZD-8848AZD-8848 is under investigation in clinical trial NCT01818869 (To Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses AZD8848 in Healthy Subjects).
AdafosbuvirAdafosbuvir is under investigation in clinical trial NCT02894905 (A Study to Evaluate the Effect of Renal Impairment on the Pharmacokinetics of AL-335).
UprifosbuvirUprifosbuvir is under investigation in clinical trial NCT02332707 (Efficacy and Safety of Grazoprevir (MK-5172) and Uprifosbuvir (MK-3682) With Elbasvir (MK-8742) or Ruzasvir (MK-8408) for Chronic Hepatitis C Genotype (GT)1 and...
GS-6620GS-6620 is under investigation in clinical trial NCT01316237 (A Study Evaluating the Safety, Tolerability, Pharmacokinetics and Antiviral Activity of GS-6620 in Treatment Naïve Subjects With Chronic Hepatitis C Virus Infection).
CYC-065CYC-065 is under investigation in clinical trial NCT03739554 (CYC065 CDK Inhibitor and Venetoclax Study in Relapsed/Refractory CLL).
MolnupiravirAn orally bioavailable isopropylester cytidine analog used to treat COVID-19.
GS-441524An experimental nucleoside analog antiviral investigated for its use in the treatment of Ebola and SARS-CoV-2 infections.
CedazuridineA cytidine deaminase inhibitor coadministered with the hypomethylating agent decitabine for the treatment of variable forms of myelodysplastic syndrome (MDS).
8-Chloroadenosine8-Chloroadenosine is under investigation in clinical trial NCT02509546 (8-chloroadenosine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia).
FluorocyclopentenylcytosineFluorocyclopentenylcytosine is under investigation in clinical trial NCT03189914 (RX-3117 in Combination With Abraxane® in Subjects With Metastatic Pancreatic Cancer).
SelodenosonSelodenoson is under investigation in clinical trial NCT00040001 (Safety and Efficacy Study of an A1-adenosine Receptor Agonist to Slow Heart Rate in Atrial Fibrillation).
BentracimabBentracimab is under investigation in clinical trial NCT04286438 (Bentracimab (PB2452) in Ticagrelor-treated Patients With Uncontrolled Major or Life-threatening Bleeding or Requiring Urgent Surgery or Invasive Procedure).
Drugs & Drug Targets
DrugTargetType
VidarabineDNA polymerase catalytic subunittarget
VidarabineThymidine kinasetarget
VidarabineThymidine kinasetarget
VidarabineAdenosine deaminaseenzyme
CladribinePurine nucleoside phosphorylasetarget
CladribineDNAtarget
CladribineDeoxycytidine kinaseenzyme
CladribineRibonucleoside-diphosphate reductase large subunittarget
CladribineRibonucleoside-diphosphate reductase subunit M2target
CladribineRibonucleoside-diphosphate reductase subunit M2 Btarget
CladribineDNA polymerase alpha catalytic subunittarget
CladribineDNA polymerase epsilon catalytic subunit Atarget
CladribineDNA polymerase epsilon subunit 2target
CladribineDNA polymerase epsilon subunit 3target
CladribineDNA polymerase epsilon subunit 4target
CladribineATP-binding cassette sub-family G member 2transporter
CladribineSolute carrier family 28 member 3transporter
GemcitabineRibonucleoside-diphosphate reductase large subunittarget
GemcitabineUMP-CMP kinasetarget
GemcitabineThymidylate synthasetarget
GemcitabineCytidine deaminaseenzyme
GemcitabineDeoxycytidine kinaseenzyme
GemcitabineP-glycoprotein 1transporter
GemcitabineMultidrug resistance-associated protein 7transporter
GemcitabineEquilibrative nucleoside transporter 1transporter
GemcitabineDNAtarget
GemcitabineSodium/nucleoside cotransporter 1transporter
GemcitabineEquilibrative nucleoside transporter 2transporter
GemcitabineSolute carrier family 28 member 3transporter
GemcitabineThymidine kinase 2, mitochondrialenzyme
GemcitabineUMP-CMP kinaseenzyme
GemcitabineNucleoside diphosphate kinase Aenzyme
AdenosineAdenosine receptor A3target
AdenosineAdenosine deaminaseenzyme
AdenosineAdenosine kinaseenzyme
AdenosineAdenosine receptor A1target
AdenosineAdenosine receptor A2atarget
AdenosineAdenosine receptor A2btarget
AdenosineSolute carrier family 28 member 3transporter
AdenosineEquilibrative nucleoside transporter 1transporter
AdenosineEquilibrative nucleoside transporter 2transporter
AdenosineEquilibrative nucleoside transporter 3transporter
AdenosineEquilibrative nucleoside transporter 4transporter
AdenosineSodium/nucleoside cotransporter 1transporter
AdenosineSodium/nucleoside cotransporter 2transporter
AdenosineGap junction alpha-1 proteintransporter
AdenosineAdenylate kinase isoenzyme 1enzyme
AdenosineNucleoside diphosphate kinase Aenzyme
AdenosineNucleoside diphosphate kinase Benzyme
AdenosinePurine nucleoside phosphorylaseenzyme
AdenosineXanthine dehydrogenase/oxidaseenzyme
AdenosineSerum albumincarrier
RibavirinRNA-directed RNA polymerase Ltarget
RibavirinRNA-directed RNA polymerase catalytic subunittarget
RibavirinInosine-5'-monophosphate dehydrogenase 1target
RibavirinGenome polyproteintarget
RibavirinInosine-5'-monophosphate dehydrogenase 2target
RibavirinAdenosine kinaseenzyme
RibavirinEquilibrative nucleoside transporter 1transporter
RibavirinSolute carrier family 28 member 3transporter
RibavirinCytosolic purine 5'-nucleotidaseenzyme
EmtricitabineReverse transcriptase/RNaseHtarget
EmtricitabineDeoxycytidine kinaseenzyme
EmtricitabineSerum albumincarrier
EmtricitabineMultidrug and toxin extrusion protein 1transporter
DecitabineDNAtarget
DecitabineDNA (cytosine-5)-methyltransferase 1target
DecitabineDeoxycytidine kinaseenzyme
DecitabineUMP-CMP kinaseenzyme
DecitabineNucleoside diphosphokinaseenzyme
DecitabineCytidine deaminaseenzyme
DecitabineDNA (cytosine-5)-methyltransferase 3Atarget
DecitabineDNA (cytosine-5)-methyltransferase 3Btarget
DecitabineSodium/nucleoside cotransporter 1transporter
DecitabineHistone deacetylasetarget
UridineU6 snRNA-associated Sm-like protein LSm6target
UridineNucleoside-specific channel-forming protein tsxtarget
UridineEquilibrative nucleoside transporter 1transporter
TicagrelorCytochrome P450 3A4enzyme
TicagrelorP2Y purinoceptor 12target
TicagrelorP-glycoprotein 1transporter
TicagrelorCytochrome P450 2C9enzyme
TicagrelorSerum albumincarrier
TicagrelorCytochrome P450 3A5enzyme
TicagrelorCytochrome P450 2B6enzyme
DichlororibofuranosylbenzimidazoleCasein kinase II subunit alphatarget
CytidineUridine-cytidine kinase 2target
GuanosineDNA polymerasetarget
GuanosinePurine nucleoside phosphorylasetarget
GuanosinePurine nucleoside phosphorylasetarget
TubercidinPurine nucleoside phosphorylase DeoD-typetarget
InosinePurine nucleoside phosphorylasetarget
InosineIAG-nucleoside hydrolasetarget
InosinePurine nucleoside phosphorylase DeoD-typetarget
InosineXanthine dehydrogenase/oxidaseenzyme
InosineSolute carrier family 28 member 3transporter
AdemetionineGlycine N-methyltransferasetarget
AdemetionineS-adenosylmethionine decarboxylase proenzymetarget
AdemetionineS-adenosylmethionine synthase isoform type-2target
AdemetionineCystathionine beta-synthasetarget
AdemetionineS-adenosylmethionine synthase isoform type-1target
AdemetionineCytochrome P450 2E1enzyme
AdemetionineCatechol O-methyltransferasetarget
AdemetionineSpermidine synthaseenzyme
AdemetionineCap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1target
AdemetionineArsenite methyltransferasetarget
DidanosineSolute carrier family 22 member 6transporter
DidanosinePurine nucleoside phosphorylasetarget
DidanosineReverse transcriptase/RNaseHtarget
DidanosineEquilibrative nucleoside transporter 1transporter
DidanosineEquilibrative nucleoside transporter 2transporter
DidanosineSerum albumincarrier
AzacitidineDNA (cytosine-5)-methyltransferase 1target
AzacitidineCytidine deaminaseenzyme
AzacitidineDNAtarget
AzacitidineRNAtarget
5-fluorouridineUridine phosphorylasetarget
5-fluorouridineSuperoxide dismutase [Cu-Zn]target
5-fluorouridineThyroxine-binding globulincarrier
S-adenosyl-L-homocysteineCap-specific mRNA (nucleoside-2'-O-)-methyltransferasetarget
S-adenosyl-L-homocysteineCobalt-precorrin-4 C(11)-methyltransferasetarget
S-adenosyl-L-homocysteineProtein-L-isoaspartate(D-aspartate) O-methyltransferasetarget
S-adenosyl-L-homocysteineGenome polyproteintarget
S-adenosyl-L-homocysteinePhenylethanolamine N-methyltransferasetarget
S-adenosyl-L-homocysteineCyclopropane mycolic acid synthase 2target
S-adenosyl-L-homocysteineModification methylase RsrItarget
S-adenosyl-L-homocysteineCatechol O-methyltransferase domain-containing protein 1target
S-adenosyl-L-homocysteineCarminomycin 4-O-methyltransferasetarget
S-adenosyl-L-homocysteineGuanidinoacetate N-methyltransferasetarget
S-adenosyl-L-homocysteineRelease factor glutamine methyltransferasetarget
S-adenosyl-L-homocysteineRelease factor glutamine methyltransferasetarget
S-adenosyl-L-homocysteineProtein arginine N-methyltransferase 3target
S-adenosyl-L-homocysteineHistamine N-methyltransferasetarget
S-adenosyl-L-homocysteineRibosomal RNA small subunit methyltransferase Htarget
S-adenosyl-L-homocysteinerRNA adenine N-6-methyltransferasetarget
S-adenosyl-L-homocysteinetRNA (cytosine(38)-C(5))-methyltransferasetarget
S-adenosyl-L-homocysteineGlycine N-methyltransferasetarget
S-adenosyl-L-homocysteinetRNA (cytidine(34)-2'-O)-methyltransferasetarget
S-adenosyl-L-homocysteineModification methylase PvuIItarget
S-adenosyl-L-homocysteineDNA adenine methylasetarget
S-adenosyl-L-homocysteineCyclopropane mycolic acid synthase 3target
S-adenosyl-L-homocysteineProtein arginine N-methyltransferase 1target
S-adenosyl-L-homocysteineSiroheme synthasetarget
S-adenosyl-L-homocysteineModification methylase HhaItarget
S-adenosyl-L-homocysteineHistone-lysine N-methyltransferase SETD7target
S-adenosyl-L-homocysteinetRNA (guanine-N(1)-)-methyltransferasetarget
S-adenosyl-L-homocysteineCyclopropane mycolic acid synthase MmaA2target
S-adenosyl-L-homocysteineDiphthine synthasetarget
S-adenosyl-L-homocysteineRdmBtarget
S-adenosyl-L-homocysteinetRNA (guanine-N(1)-)-methyltransferasetarget
S-adenosyl-L-homocysteineUroporphyrinogen-III C-methyltransferasetarget
S-adenosyl-L-homocysteineUncharacterized proteintarget
S-adenosyl-L-homocysteineChemotaxis protein methyltransferasetarget
S-adenosyl-L-homocysteineModification methylase TaqItarget
S-adenosyl-L-homocysteineProtein-L-isoaspartate O-methyltransferasetarget
S-adenosyl-L-homocysteineHistamine N-methyltransferaseenzyme
SinefunginModification methylase RsrItarget
SinefunginRdmBtarget
SinefunginrRNA adenine N-6-methyltransferasetarget
SinefunginModification methylase TaqItarget
FormycinS-methyl-5'-thioadenosine phosphorylasetarget
Formycin5'-methylthioadenosine/S-adenosylhomocysteine nucleosidasetarget
9-deazainosinePurine nucleoside phosphorylasetarget
S-Adenosyl-1,8-Diamino-3-ThiooctaneSpermidine synthasetarget
MethylthioinosinePurine nucleoside phosphorylase DeoD-typetarget
ZebularineCytidine deaminasetarget
Deoxycytidylyl-3',5'-guanosineRibonuclease pancreatictarget
5'-O-(N-(Alanyl)sulfamoyl)adenosineBifunctional glutamate/proline--tRNA ligasetarget
7-MethylguanosineCap-specific mRNA (nucleoside-2'-O-)-methyltransferasetarget
Formycin BPurine nucleoside phosphorylase DeoD-typetarget
Formycin BHypoxanthine-guanine phosphoribosyltransferasetarget
3-DeazacytidineCytidine deaminasetarget
2-FluoroadenosinePurine nucleoside phosphorylase DeoD-typetarget
3-DeazaadenosineIAG-nucleoside hydrolasetarget
5-iodotubercidinCasein kinase I isoform gamma-2target
5-iodotubercidinSerine/threonine-protein kinase haspintarget
5-iodotubercidinMitogen-activated protein kinase 3target
CyclouridineUridine phosphorylasetarget
BinodenosonAdenosine receptor A2atarget
IsatoribineToll-like receptor 7target
TecadenosonAdenosine receptor A1target
DenufosolP2Y purinoceptor 2target
PiclidenosonAdenosine receptor A3target
TaribavirinDNAtarget
TaribavirinRNA-directed RNA polymerase Ltarget
TaribavirinEctonucleotide pyrophosphatase/phosphodiesterase family member 1target
TaribavirinRNA-directed RNA polymerase catalytic subunittarget
TaribavirinCytosolic purine 5'-nucleotidasetarget
TaribavirinInosine-5'-monophosphate dehydrogenase 1target
N(6)-dimethylallyladenineCyclin-dependent kinase 2target
SofosbuvirP-glycoprotein 1transporter
SofosbuvirATP-binding cassette sub-family G member 2transporter
SofosbuvirRNA-dependent RNA-polymerasetarget
SofosbuvirLysosomal protective proteinenzyme
SofosbuvirCarboxylesteraseenzyme
SofosbuvirHistidine triad nucleotide-binding protein 1enzyme
SofosbuvirUMP-CMP kinaseenzyme
SofosbuvirNucleoside diphosphate kinase Aenzyme
GalidesivirRNA-directed RNA polymerase Ltarget
GS-441524Replicase polyprotein 1abtarget
GS-441524RNA-directed RNA polymerase Ltarget
CedazuridineCytidine deaminasetarget