- Accession Number
Nucleosides in which the purine or pyrimidine base is combined with ribose. (Dorland, 28th ed)
Drug Drug Description Vidarabine An antiviral agent used to treat various viral infections. Cladribine A purine antimetabolite used for the management of relapsing forms of Multiple Sclerosis (MS), used in patients who have not responded to or who were unable to tolerate alternative MS drugs. Gemcitabine A nucleoside metabolic inhibitor used as adjunct therapy in the treatment of certain types of ovarian cancer, non-small cell lung carcinoma, metastatic breast cancer, and as a single agent for pancreatic cancer. Adenosine A medication used in myocardial perfusion scintigraphy and to treat supraventricular tachycardia. Ribavirin A guanosine nucleoside used to treat some forms of Hepatitis C. Emtricitabine A nucleoside reverse transcriptase inhibitor used for the treatment and prophylaxis of HIV. Decitabine A chemotherapeutic pyrimidine nucleoside analogue used for the treatment of myelodysplastic syndromes (MDS) by inducing DNA hypomethylation and corresponding alterations in gene expression. Uridine A drug used to manage neuropsychiatric deficits associated with cerebrovascular diseases in combination with cytidine. Ticagrelor A P2Y12 platelet inhibitor used in patients with a history of myocardial infarction or with acute coronary syndrome (ACS) to prevent future myocardial infarction, stroke and cardiovascular death. Toyocamycin 4-Amino-5-cyano-7-(D-ribofuranosyl)-7H- pyrrolo(2,3-d)pyrimidine. Antibiotic antimetabolite isolated from Streptomyces toyocaensis cultures. It is an analog of adenosine, blocks RNA synthesis and ribosome function, and is used mainly as a tool in biochemistry. Dichlororibofuranosylbenzimidazole Not Available N4-Hydroxycytidine A cytidine analog being investigated to treat COVID-19. Cytidine A drug used to manage neuropsychiatric deficits associated with cerebrovascular diseases in combination with uridine. Guanosine Guanosine is a nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine can be phosphorylated to become GMP (guanosine monophosphate), cGMP (cyclic guanosine monophosphate), GDP... Tubercidin An antibiotic purine ribonucleoside that readily substitutes for adenosine in the biological system, but its incorporation into DNA and RNA has an inhibitory effect on the metabolism of these nucleic... Inosine A nutritional supplement touted to improve athletic performance and a drug used in vitro as a red blood cell rejuvenator for a unit of red blood cells that will be used in a clinical setting. Ademetionine S-Adenosylmethionine (SAMe) is used as a drug in Europe for the treatment of depression, liver disorders, fibromyalgia, and osteoarthritis. It has also been introduced into the United States market as... Didanosine A reverse transcriptase inhibitor used to treat HIV. Azacitidine A pyrimidine nucleoside analogue used to treat certain subtypes of myelodysplastic syndrome. 5-fluorouridine 5-fluorouridine is also known as FUrd, 5-Fluorouracil 1-beta-D-ribofuranoside, 5-Fur, or 5-Fluoro-uridine. 5-fluorouridine is a solid. This compound belongs to the pyrimidine nucleosides and analogues. These are compounds comprising a pyrimidine... S-adenosyl-L-homocysteine 5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine. Formed from S-adenosylmethionine after transmethylation reactions. Sinefungin Sinefungin is a solid. This compound belongs to the purine nucleosides and analogues. These are compounds comprising a purine base attached to a sugar. The proteins that adenosyl-ornithine target include... Formycin Not Available Deoxyinosine Not Available 8-hydroxy-2'-deoxyguanosine Not Available 9-deazainosine Not Available S-Adenosyl-1,8-Diamino-3-Thiooctane Not Available Methylthioinosine An analog of inosine with a methylthio group replacing the hydroxyl group in the 6-position. Zebularine A chemically stable, cytidine analog that displays anti-tumor properties. It acts as a transition state analog inhibitor of cytidine deaminase by binding to the active site as covalent hydrates. Also... Deoxycytidylyl-3',5'-guanosine Not Available 5'-O-(N-(Alanyl)sulfamoyl)adenosine Not Available 7-Methylguanosine Not Available Formycin B Not Available 3-Deazacytidine Not Available 2-Fluoroadenosine Not Available 3-Deazaadenosine Not Available 5-iodotubercidin Not Available Cyclouridine Not Available Binodenoson For cardiac pharmacologic stress SPECT imaging, which is used to diagnose coronary artery disease. Isatoribine For the treatment of Hepatitis C. Tecadenoson Investigated for use/treatment in arrhythmia and atrial fibrillation. Denufosol For use as an inhaled treatment for cystic fibrosis. Piclidenoson Investigated for use/treatment in cancer/tumors (unspecified), eye disorders/infections, psoriasis and psoriatic disorders, and rheumatoid arthritis. Can-Fite BioPharma has reported that by targeting the adenosine A3-receptor, CF101 may also be used... Taribavirin Investigated for use/treatment in hepatitis (viral, C). TAS-106 Investigated for use/treatment in solid tumors and cancer/tumors (unspecified). N(6)-dimethylallyladenine Not Available Sofosbuvir A direct-acting antiviral agent used to treat specific hepatitis C virus (HCV) infections in combination with other antiviral agents. Uridine triacetate A pyrimidine analog used for the reversal of overdose, regardless of the presence of symptoms, and early-onset, severe or life-threatening CNS toxicity or cardiotoxicity of fluorouracil or capecitabine. Galidesivir Galidesivir is an adenosine analogue that has been investigated for use against Zaire Ebolavirus. In animal studies, galidesivir was effective in increasing the survival rates from infections caused by various... Guadecitabine Guadecitabine is under investigation for the treatment of Previously Treated Metastatic Colorectal Cancer. Sonedenoson Sonedenoson has been used in trials studying the treatment of Foot Ulcer, Diabetic and Diabetes Complications. Tetrahydrouridine Tetrahydrouridine has been used in trials studying the treatment of Neoplasms, Lung Neoplasms, Breast Neoplasms, Sickle Cell Disease, and Head and Neck Cancer, among others. UK-432097 UK-432,097 has been used in trials studying the treatment of Pulmonary Disease, Chronic Obstructive. Trabodenoson Trabodenoson has been used in trials studying the treatment of Ocular Hypertension (OHT) and Primary Open-Angle Glaucoma (POAG). Inosine pranobex A medication used to treat subacute sclerosing panencephalitis. Tiazofurine Tiazofurine has potential clinical use in cancer treatment as it is a potential inhibitor of Inosine- 5’-monophosphate (IMP) dehydrogenase . 2'-C-methylcytidine A nucleoside analog with anti-hepatitis C virus (HCV) activity. Upon phosphorylation into its 5-triphosphate form, this metabolite inhibits viral RNA chain elongation and viral RNA-dependent RNA polymerase activity. This blocks... AZD-8848 AZD-8848 is under investigation in clinical trial NCT01818869 (To Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses AZD8848 in Healthy Subjects). Adafosbuvir Adafosbuvir is under investigation in clinical trial NCT02894905 (A Study to Evaluate the Effect of Renal Impairment on the Pharmacokinetics of AL-335). Uprifosbuvir Uprifosbuvir is under investigation in clinical trial NCT02332707 (Efficacy and Safety of Grazoprevir (MK-5172) and Uprifosbuvir (MK-3682) With Elbasvir (MK-8742) or Ruzasvir (MK-8408) for Chronic Hepatitis C Genotype (GT)1 and... GS-6620 GS-6620 is under investigation in clinical trial NCT01316237 (A Study Evaluating the Safety, Tolerability, Pharmacokinetics and Antiviral Activity of GS-6620 in Treatment Naïve Subjects With Chronic Hepatitis C Virus Infection). CYC-065 CYC-065 is under investigation in clinical trial NCT03739554 (CYC065 CDK Inhibitor and Venetoclax Study in Relapsed/Refractory CLL). Molnupiravir An orally bioavailable isopropylester cytidine analog used to treat COVID-19. GS-441524 An experimental nucleoside analog antiviral investigated for its use in the treatment of Ebola and SARS-CoV-2 infections. Cedazuridine A cytidine deaminase inhibitor coadministered with the hypomethylating agent decitabine for the treatment of variable forms of myelodysplastic syndrome (MDS). 8-Chloroadenosine 8-Chloroadenosine is under investigation in clinical trial NCT02509546 (8-chloroadenosine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia). Fluorocyclopentenylcytosine Fluorocyclopentenylcytosine is under investigation in clinical trial NCT03189914 (RX-3117 in Combination With Abraxane® in Subjects With Metastatic Pancreatic Cancer). Selodenoson Selodenoson is under investigation in clinical trial NCT00040001 (Safety and Efficacy Study of an A1-adenosine Receptor Agonist to Slow Heart Rate in Atrial Fibrillation). Bentracimab Bentracimab is under investigation in clinical trial NCT04286438 (Bentracimab (PB2452) in Ticagrelor-treated Patients With Uncontrolled Major or Life-threatening Bleeding or Requiring Urgent Surgery or Invasive Procedure). AMG-319 Not Annotated Namodenoson Namodenoson has been used in trials studying the treatment of Chronic Hepatitis C and Hepatocellular Carcinoma. 5,6-dihydro-5-azacytidine Not Annotated Loxoribine Not Available Maribavir A cytomegalovirus (CMV) pUL97 kinase inhibitor used for the treatment of refractory post-transplant CMV infection.
- Drugs & Drug Targets