Phenethylamines

Name
Phenethylamines
Accession Number
DBCAT000432
Description

A group of compounds that are derivatives of beta- aminoethylbenzene which is structurally and pharmacologically related to amphetamine. (From Merck Index, 11th ed)

Drugs
DrugDrug Description
AmphetamineA CNS stimulant and sympathomimetic agent indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD).
PhentermineA sympathomimetic anorectic agent used as a short-term adjunct therapy that is included in a regimen of weight reduction in cases of exogenous obesity.
VenlafaxineA selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of major depression.
SapropterinA cofactor used as an adjunct to phenylalanine restriction in the treatment of phenylketonuria (PKU).
FenfluramineFenfluramine is a phenethylamine that is structurally similar to serotonin. Due to its ability to increase extracellular serotonin levels, modulate serotonergic and other neurologic receptors, and control neurotransmission, it is effective in treating pharmacoresistant seizures.
MethoxamineAn alpha adrenergic agonist used to treat hypotension.
DobutamineA beta-1 agonist used to treat cardiac decompensation in patients with organic heart disease or from cardiac surgery.
PseudoephedrineAn alpha and beta adrenergic agonist used to treat nasal and sinus congestion, as well as allergic rhinitis.
BenzphetamineA sympathomimetic used to manage exogenous obesity short term.
RitodrineAn adrenergic beta agonist used to treat premature labor.
SalmeterolA long-acting beta-2 adrenergic receptor agonist used to treat asthma and COPD.
SalbutamolA beta-2 adrenergic receptor agonist used to treat asthma, bronchitis, COPD, as well as prevent exercise induced bronchospasms.
SelegilineA monoamine oxidase inhibitor used to treat major depressive disorder and Parkinson's.
DexfenfluramineFor the management of obesity including weight loss and maintenance of weight loss in patients on a reduced calorie diet
LisdexamfetamineA central nervous system (CNS) stimulant used to treat attention deficit hyperactivity disorder (ADHD) and moderate to severe eating disorders.
EphedrineAn alpha and beta-adrenergic agonist indicated to treat hypotension under anesthesia, allergic conditions, bronchial asthma, and nasal congestion.
MephentermineA sympathomimetic agent used in the treatment of hypotension.
MMDAMMDA is a recreational drug. It has no current medical uses and is a Schedule I controlled substance in the USA at present.
MidomafetamineClinical trials are now testing the therapeutic potential of MDMA for post-traumatic stress disorder (PTSD) and anxiety associated with terminal cancer. MDMA is one of the four most widely used...
2,5-DimethoxyamphetamineNot Available
2,5-Dimethoxy-4-ethylamphetamineNot Available
4-MethoxyamphetamineNot Available
FenethyllineNot Available
4-Bromo-2,5-dimethoxyamphetamineNot Available
TenamfetamineAn amphetamine derivative that inhibits uptake of catecholamine neurotransmitters. It is a hallucinogen. It is less toxic than its methylated derivative but in sufficient doses may still destroy serotonergic neurons...
4-Bromo-2,5-dimethoxyphenethylamineNot Available
FenproporexFenproporex is used as an appetite suppressant, and anti-obesity agent [2]; however, due to substance abuse potential, it is an illicit substance in many countries. In some countries, such as...
ChlorphentermineUsed as an appetite suppressant.
DextroamphetamineA sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy.
MetamfetamineA sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and exogenous obesity.
PrenylaminePrenylamine was withdrawn from the Canadian, US, and UK markets in 1988 due to concerns regarding cardiac arrhythmias.
NylidrinA vasodilator used to treat patients with peripheral vascular disorders, and elderly patients with symptoms associated with organic mental disorders.
IsoxsuprineA beta-adrenergic agonist used in the symptomatic treatment of cerebrovascular insufficiency, peripheral vascular disease of arteriosclerosis obliterans, thromboangiitis obliterans (Buerger's disease) and Raynaud's disease.
HexoprenalineHexoprenaline is a stimulant of beta 2 adrenergic receptors. It is used as a bronchodilator, antiasthmatic, and tocolytic agent.
FendilineFendiline is a coronary vasodilator which inhibits calcium function in muscle cells in excitation-contraction coupling. It has been proposed as an antiarrhythmic and antianginal agent. Fendiline is non-selective.
BenfluorexBenfluorex is an anorectic and hypolipidemic agent that is structurally related to fenfluramine. It was patented and manufactured by a French pharmaceutical company Servier. The European Medicines Agency (EMA) recommended...
HydroxyamphetamineAn indirectly acting sympathomimetic agent producing mydriasis for diagnostic purposes.
Iofetamine I-123Not Annotated
EtafedrineA beta-2 adrenoceptor agonist used to treat a cough associated with inflamed mucosa.
OxilofrineAn amphetamine used to treat a cough associated with inflamed mucosa.
RitobegronRitobegron is under investigation in clinical trial NCT02256735 (Study to Investigate the Effect of KUC 7483 CL on the QT/QTc Interval of the ECG in Comparison to Placebo and Moxifloxacin...
GallopamilGallopamil has been used in trials studying the treatment of Asthma.
MephedroneMephedrone has been investigated in Alcohol-Related Disorders and Amphetamine-Related Disorders.
LevosalbutamolA beta-2 adrenergic receptor agonist used to treat COPD and asthma.
OctopamineOctopamine is structurally similar to norepinephrine. It has been used as a nootropic, and therefore it and all of its enantiomer are prohibited by the World Anti-doping Agency (WADA) as...
SuloctidilNot Annotated
NorfenefrineNot Annotated
OxyfedrineNot Annotated
ClobenzorexNot Annotated
MethoxyphenamineNot Annotated
GepefrineNot Annotated
MefenorexNot Annotated
2,5-Dimethoxy-4-ethylthioamphetamine2,5-Dimethoxy-4-ethylthioamphetamine (ALEPH-2) is a phenylisopropylamine derivative with alleged anxiolytic and hallucinogenic properties.
DexverapamilNot Annotated
EmopamilPrevents renal injury after warm & cold ischemia.
MethylenedioxyethamphetamineNot Available
Hexamethylene diamineNot Available
CarmoterolNot Annotated
Drugs & Drug Targets
DrugTargetType
AmphetamineSodium-dependent dopamine transportertarget
AmphetamineCocaine- and amphetamine-regulated transcript proteintarget
AmphetamineTrace amine-associated receptor 1target
AmphetamineCytochrome P450 2D6enzyme
AmphetamineSolute carrier family 22 member 3transporter
AmphetamineSolute carrier family 22 member 5transporter
AmphetamineSynaptic vesicular amine transportertarget
AmphetamineCytochrome P450 2A6enzyme
AmphetamineSodium-dependent noradrenaline transportertarget
AmphetamineAlpha adrenergic receptortarget
AmphetamineBeta adrenergic receptortarget
AmphetamineDopamine D2 receptortarget
AmphetamineAmine oxidase [flavin-containing] Btarget
AmphetamineSodium-dependent serotonin transportertarget
AmphetamineMonoamine oxidasetarget
Amphetaminevesicular monoamine transporter 2 (VMAT2)target
PhentermineSodium-dependent noradrenaline transportertarget
PhentermineSodium-dependent dopamine transportertarget
PhentermineAmine oxidase [flavin-containing] Atarget
PhentermineAmine oxidase [flavin-containing] Btarget
PhentermineSodium-dependent serotonin transportertarget
PhenterminePro-neuropeptide Ytarget
PhentermineCytochrome P450 3A4enzyme
VenlafaxineSodium-dependent serotonin transportertarget
VenlafaxineSodium-dependent noradrenaline transportertarget
VenlafaxineCytochrome P450 2D6enzyme
VenlafaxineCytochrome P450 3A4enzyme
VenlafaxineSodium-dependent dopamine transportertarget
VenlafaxineP-glycoprotein 1transporter
VenlafaxineATP-binding cassette sub-family G member 2transporter
SapropterinPhenylalanine-4-hydroxylasetarget
SapropterinNitric oxide synthase, endothelialtarget
SapropterinTyrosine 3-monooxygenasetarget
SapropterinTryptophan 5-hydroxylase 1target
SapropterinProstaglandin G/H synthase 2enzyme
Fenfluramine5-hydroxytryptamine receptor 2Ctarget
Fenfluramine5-hydroxytryptamine receptor 2Btarget
FenfluramineCytochrome P450 2D6enzyme
FenfluramineSodium-dependent serotonin transportertarget
Fenfluramine5-hydroxytryptamine receptor 2Atarget
FenfluramineSodium-dependent serotonin transportertransporter
Fenfluramine5-hydroxytryptamine receptor 1Dtarget
FenfluramineSigma non-opioid intracellular receptor 1target
Fenfluramine5-hydroxytryptamine receptor 1Atarget
FenfluramineCytochrome P450 1A2enzyme
FenfluramineCytochrome P450 2B6enzyme
FenfluramineCytochrome P450 2C9enzyme
FenfluramineCytochrome P450 2C19enzyme
FenfluramineCytochrome P450 3A4enzyme
FenfluramineCytochrome P450 3A5enzyme
MethoxamineAlpha-1A adrenergic receptortarget
MethoxamineAlpha-1B adrenergic receptortarget
MethoxamineAlpha-1D adrenergic receptortarget
DobutamineBeta-1 adrenergic receptortarget
DobutamineCatechol O-methyltransferaseenzyme
DobutamineBeta-2 adrenergic receptortarget
DobutamineAlpha-1 adrenergic receptorstarget
DobutamineEstrogen receptor alphatarget
PseudoephedrineAlpha-1A adrenergic receptortarget
PseudoephedrineAlpha-2A adrenergic receptortarget
PseudoephedrineBeta-2 adrenergic receptortarget
PseudoephedrineAmine oxidase [flavin-containing] Aenzyme
PseudoephedrineBeta-1 adrenergic receptortarget
PseudoephedrineSodium-dependent dopamine transportertarget
PseudoephedrineSodium-dependent noradrenaline transportertarget
PseudoephedrineSodium-dependent serotonin transportertarget
PseudoephedrineNuclear factor of activated T-cells, cytoplasmic 1target
PseudoephedrineTumor necrosis factortarget
PseudoephedrineNuclear factor NF-kappa-B p105 subunittarget
Pseudoephedrineactivator protein 1target
PseudoephedrineInterleukin-2target
PseudoephedrineSerum albumincarrier
PseudoephedrineSodium-dependent noradrenaline transportertransporter
PseudoephedrineSodium-dependent dopamine transportertransporter
PseudoephedrineSodium-dependent serotonin transportertransporter
BenzphetamineAlpha-2A adrenergic receptortarget
BenzphetamineAlpha-1A adrenergic receptortarget
BenzphetamineCytochrome P450 3A4enzyme
BenzphetamineCytochrome P450 2B6enzyme
BenzphetamineNADPH--cytochrome P450 reductaseenzyme
BenzphetamineSynaptic vesicular amine transportertarget
BenzphetamineSodium-dependent dopamine transportertarget
RitodrineBeta-2 adrenergic receptortarget
Ritodrine6-phosphogluconate dehydrogenase, decarboxylatingenzyme
SalmeterolBeta-2 adrenergic receptortarget
SalmeterolCytochrome P450 3A4enzyme
SalmeterolCytochrome P450 2C8enzyme
SalmeterolCytochrome P450 3A5enzyme
SalmeterolCytochrome P450 3A7enzyme
SalmeterolBeta-1 adrenergic receptortarget
SalmeterolBeta-3 adrenergic receptortarget
SalmeterolSerum albumincarrier
Salmeterolalpha1-acid glycoproteincarrier
SalmeterolSolute carrier family 22 member 1transporter
SalmeterolSolute carrier family 22 member 2transporter
SalmeterolSolute carrier family 22 member 3transporter
SalbutamolBeta-2 adrenergic receptortarget
SalbutamolBeta-1 adrenergic receptortarget
SalbutamolCytochrome P450 3A4enzyme
SalbutamolBeta-3 adrenergic receptortarget
SelegilineAmine oxidase [flavin-containing] Btarget
SelegilineCytochrome P450 2B6enzyme
SelegilineAmine oxidase [flavin-containing] Atarget
SelegilineCytochrome P450 2A6enzyme
SelegilineCytochrome P450 3A4enzyme
SelegilineP-glycoprotein 1transporter
SelegilineCytochrome P450 1A2enzyme
SelegilineCytochrome P450 2C19enzyme
SelegilineCytochrome P450 2C8enzyme
SelegilineCytochrome P450 2C9enzyme
SelegilineCytochrome P450 2D6enzyme
SelegilineCytochrome P450 2E1enzyme
DexfenfluramineSodium-dependent serotonin transportertarget
Dexfenfluramine5-hydroxytryptamine receptor 2Ctarget
DexfenfluramineCytochrome P450 2D6enzyme
DexfenfluramineCytochrome P450 1A2enzyme
DexfenfluramineCytochrome P450 2E1enzyme
LisdexamfetamineCytochrome P450 2D6enzyme
LisdexamfetamineSolute carrier family 15 member 1transporter
LisdexamfetamineTrace amine-associated receptor 1target
EphedrineAlpha-1A adrenergic receptortarget
EphedrineSodium-dependent noradrenaline transportertarget
EphedrineCholinesteraseenzyme
EphedrineSerum albumincarrier
EphedrineBeta-1 adrenergic receptortarget
EphedrineBeta-2 adrenergic receptortarget
EphedrineSynaptic vesicular amine transportertransporter
EphedrineAcetylcholinesteraseenzyme
MephentermineAlpha adrenergic receptortarget
MephentermineBeta adrenergic receptortarget
MMDA5-hydroxytryptamine receptor 2Atarget
MMDASodium-dependent serotonin transportertarget
MMDASodium-dependent dopamine transportertarget
MMDAChromaffin granule amine transportertarget
MMDASynaptic vesicular amine transportertarget
MMDAAmine oxidase [flavin-containing] Atarget
MMDAAmine oxidase [flavin-containing] Btarget
MMDASodium-dependent noradrenaline transportertarget
MidomafetamineSodium-dependent serotonin transportertarget
MidomafetamineSynaptic vesicular amine transportertarget
MidomafetamineSodium-dependent dopamine transportertarget
Midomafetamine5-hydroxytryptamine receptor 2Atarget
Midomafetamine5-hydroxytryptamine receptor 2Btarget
Midomafetamine5-hydroxytryptamine receptor 2Ctarget
MidomafetamineSodium-dependent noradrenaline transportertarget
MidomafetamineSodium-dependent noradrenaline transportertransporter
MidomafetamineSodium-dependent dopamine transportertransporter
MidomafetamineSodium-dependent serotonin transportertransporter
MidomafetamineCytochrome P450 2D6enzyme
4-MethoxyamphetamineAlpha-1A adrenergic receptortarget
4-MethoxyamphetamineAlpha-2A adrenergic receptortarget
4-MethoxyamphetamineCytochrome P450 2D6enzyme
4-MethoxyamphetamineSodium-dependent dopamine transportertarget
4-MethoxyamphetamineSodium-dependent serotonin transportertarget
4-MethoxyamphetamineAmine oxidase [flavin-containing] Atarget
4-MethoxyamphetamineAmine oxidase [flavin-containing] Btarget
4-MethoxyamphetamineSynaptic vesicular amine transportertarget
FenethyllineCytochrome P450 1A2enzyme
4-Bromo-2,5-dimethoxyphenethylamine5-hydroxytryptamine receptor 2Ctarget
4-Bromo-2,5-dimethoxyphenethylamine5-hydroxytryptamine receptor 2Atarget
DextroamphetamineAlpha-1B adrenergic receptortarget
DextroamphetamineSodium-dependent dopamine transportertarget
DextroamphetamineSodium-dependent noradrenaline transportertarget
DextroamphetamineSynaptic vesicular amine transportertarget
DextroamphetamineTrace amine-associated receptor 1target
DextroamphetamineCytochrome P450 2D6enzyme
DextroamphetaminePrimary amine oxidaseenzyme
DextroamphetamineSodium-dependent dopamine transportertransporter
DextroamphetamineAlpha adrenergic receptortarget
MetamfetamineCytochrome P450 2D6enzyme
MetamfetamineSolute carrier family 22 member 3transporter
MetamfetamineSolute carrier family 22 member 5transporter
MetamfetamineSodium-dependent dopamine transportertarget
MetamfetamineSynaptic vesicular amine transportertarget
MetamfetamineTrace amine-associated receptor 1target
MetamfetamineSodium-dependent serotonin transportertarget
MetamfetamineSodium-dependent noradrenaline transportertarget
MetamfetamineChromaffin granule amine transportertarget
MetamfetamineAmine oxidase [flavin-containing] Atarget
MetamfetamineAmine oxidase [flavin-containing] Btarget
MetamfetamineAlpha-2A adrenergic receptortarget
MetamfetamineAlpha-2B adrenergic receptortarget
MetamfetamineAlpha-2C adrenergic receptortarget
PrenylamineCalmodulintarget
PrenylamineMyosin light chain kinase 2, skeletal/cardiac muscletarget
PrenylamineCytochrome P450 3A4enzyme
NylidrinCatechol O-methyltransferaseenzyme
NylidrinVoltage-dependent T-type calcium channel subunit alpha-1Itarget
NylidrinInterferon alpha/beta receptor 2target
NylidrinCytochrome P450 3A4enzyme
FendilineCytochrome P450 3A4enzyme
EtafedrineBeta-2 adrenergic receptortarget
GallopamilCytochrome P450 3A4enzyme
GallopamilP-glycoprotein 1transporter
LevosalbutamolBeta-2 adrenergic receptortarget
LevosalbutamolCytochrome P450 3A4enzyme
LevosalbutamolCytochrome P450 2D6enzyme
LevosalbutamolSolute carrier organic anion transporter family member 1B1transporter
LevosalbutamolSolute carrier organic anion transporter family member 1B3transporter
2,5-Dimethoxy-4-ethylthioamphetamine5-hydroxytryptamine receptor 2Atarget
2,5-Dimethoxy-4-ethylthioamphetamine5-hydroxytryptamine receptor 2Ctarget
DexverapamilP-glycoprotein 1target
DexverapamilCytochrome P450 3A4enzyme
DexverapamilP-glycoprotein 1transporter
EmopamilP-glycoprotein 1target
EmopamilCytochrome P450 3A4enzyme
EmopamilP-glycoprotein 1transporter
Hexamethylene diamineAgmatinase, putativetarget