Secologanin Tryptamine Alkaloids
- Secologanin Tryptamine Alkaloids
- Accession Number
Alkaloids from Rauwolfia serpentina Benth and other species. The prototype is RESERPINE, which is a depleter of catecholamines and serotonin from the sympathetic postganglionic fibers and brain areas. They have been used in hypertension and psychoses despite their wide range of potentially adverse effects.
- ATC Classification
Drug Drug Description Reserpine For the treatment of hypertension Bietaserpine Not Annotated Vindesine A vinca alkaloid derived from vinblastine used for various types of malignancies, but mainly acute lymphocytic leukemia (ALL). Vinorelbine A vinca alkaloid used in the treatment of metastatic non-small cell lung carcinoma (NSLC) and in conjunction with other drugs in locally advanced NSCLC. Vincristine A vinca alkaloid used to treat acute leukemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute panmyelosis. Vinblastine A vinca alkaloid used to treat breast cancer, testicular cancer, neuroblastoma, Hodgkin's and non-Hodgkins lymphoma, mycosis fungoides, histiocytosis, and Kaposi's sarcoma. Deserpidine An alkaloid that has been used to manage hypertension. Rescinnamine For the treatment of hypertension. Yohimbine An alpha-2-adrenergic blocker and sympatholytic found in supplements used to. Ajmaline An antiarrhythmic used to manage a variety of forms of tachycardias. Voacamine For the treatment of malaria. Also under investigation for the modulation of multidrug resistance in cancer cells. Vintafolide Investigated for use/treatment in solid tumors. Vinflunine A vinca alkaloid used to treat advanced or metastatic transitional cell carcinoma of the urothelial tract after a platinum containing treatment has failed. Vinpocetine A synthetic derivative of a vinca alkaloid used to treat neurological symptoms of cerebrovascular disease. Vincamine Vincamine is a monoterpenoid indole alkaloid obtained from the leaves of Vinca minor with a vasodilatory property. Studies indicate that vincamine increases the regional cerebral blood flow. Prajmaline Not Annotated Lorajmine Not Annotated Vinburnine Not Annotated Methoserpidine Not Annotated Rauwolfia serpentina root Rauwolfia alkaloids are indicated in the treatment of hypertension . Rauwolfia alkaloids have been used for relief of symptoms in agitated psychotic states such as schizophrenia; however, use as antipsychotics... Almitrine For the treatment of chronic obstructive pulmonary disease. 18-methoxycoronaridine 18-methoxycoronaridine is under investigation in clinical trial NCT03084952 (Phase 2 Trial to Evaluate 18-Methoxycoronaridine Efficacy, Safety and Tolerability in Cutaneous Leishmaniasis Patients). Deacetoxyvinzolidine Not Available Strychnine Not Annotated
- Drugs & Drug Targets