Isoquinolines
- Name
- Isoquinolines
- Accession Number
- DBCAT000551
- Description
A group of compounds with the heterocyclic ring structure of benzo(c)pyridine. The ring structure is characteristic of the group of opium alkaloids such as papaverine. (From Stedman, 25th ed)
- Drugs
Drug Drug Description 5-(2-methylpiperazine-1-sulfonyl)isoquinoline Not Available 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline Potent reversible inhibitor of phenylethanolamine N-methyltransferase. Abanoquil Abanoquil is a small molecule drug. Abanoquil has a monoisotopic molecular weight of 395.18 Da. Alcuronium A non-depolarizing skeletal muscle relaxant similar to tubocurarine. It is used as an anesthesia adjuvant. Apomorphine A morphine derivative D2 dopamine agonist used to treat hypomobile "off" episodes of advanced Parkinson's disease. Atracurium A neuromuscular blocker indicated to relax muscles during mechanical ventilation under general anesthesia or intubation. Atracurium besylate A non-depolarizing neuromuscular blocker used to facilitate endotracheal intubation and relax skeletal muscles during surgery. Berbamine Not Annotated Bicuculline Bicuculline is a light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and... Bisobrin Bisobrin is a small molecule drug. Bisobrin has a monoisotopic molecular weight of 440.27 Da. Cepharanthine Not Annotated Cisatracurium A skeletal muscle relaxant used to facilitate tracheal intubation, muscle relaxation in surgery, or mechanical ventilation. Debrisoquine For the treatment of moderate and severe hypertension, either alone or as an adjunct, and for the treatment of renal hypertension. Dehydroemetine Not Annotated Drotaverine A phosphodiesterase-4 inhibitor used to alleviate gastrointestinal and genitourinary smooth muscle spasms. Elacridar For the treatment of solid tumors. Emetine Not Annotated Fasudil Fasudil has been investigated in Carotid Stenosis. Florquinitau (18F) A fluorine-18 radioactive diagnostic tracer that binds aggregated tau and is used for brain PET imaging to identify tau neurofibrillary tangle pathology in adults with cognitive impairment being evaluated for Alzheimer's disease. Higenamine Higenamine is under investigation in clinical trial NCT01451229 (Pharmacokinetics and Pharmacodynamics of Higenamine in Chinese Healthy Subjects). Hydrastine Not Annotated Hydrastinine Not Annotated Hydroxyfasudil Not Available Metocurine Metocurine is a muscle relaxant. Metocurine iodide For use as an anesthesia adjunct to induce skeletal muscle relaxation and to reduce the intensity of muscle contractions in convulsive therapy. Mitonafide Mitonafide is a small molecule drug. Mitonafide has a monoisotopic molecular weight of 313.11 Da. Mivacurium A short-acting non-depolarizing neuromuscular blocking agent used to induce anesthesia during intubation and promote skeletal muscle relaxation during surgery or mechanical ventilation. Moexipril An angiotensin converting enzyme inhibitor prodrug used to treat hypertension. Moexiprilat The active metabolite of the prodrug Moexipril. Moxaverine Moxaverine has been investigated for the treatment of Retina, Ocular Physiology, and Regional Blood Flow. Nelfinavir A viral protease inhibitor used in the treatment of HIV infection. Nomifensine Nomifensine, formerly marketed as Merital capsules, was associated with an increased incidence of hemolytic anemia. The approved application holder removed Merital capsules from the market on January 23, 1986. FDA... Noscapine A non-sedating isoquinoline alkaloid used primarily for its antitussive properties. Palonosetron A serotonin antagonist used in the prophylaxis or management of vomiting that results from emetogenic chemotherapy, and for the management of postoperative nausea and vomiting. Papaverine An alkaloid used to treat many types of smooth muscle spasms such as "vascular spasms" associated with acute myocardial infarction and angina pectoris, as well as "visceral spasms". Papaveroline Papaveroline is a small molecule drug. Papaveroline has a monoisotopic molecular weight of 283.08 Da. Praziquantel An anthelmintic medication used to treat parasitic worm infections such as schistosomiasis, clonorchiasis, and opisthorchiasis Quinapril An ACE inhibitor prodrug used to treat hypertension, congestive heart failure, and slow rate of progression of renal disease. Quinaprilat The active metabolite of the prodrug quinapril. Revaprazan Revaprazan is under investigation in clinical trial NCT01750437 (Phase 2 Clinical Trial to Investigate the Safety, Tolerability and Efficacy of YH1885L in Patients With Non-erosive Reflux Disease(nerd)). S-23 An androgen receptor modulator. Saquinavir An HIV protease inhibitor used in combination with other antiretroviral agents for the treatment of HIV-1 with advanced immunodeficiency. Solifenacin A muscarinic antagonist with antispasmodic properties used to treat urge urinary incontinence, urgency, and urinary frequency associated with an overactive bladder. Tetrandrine Not Annotated Trabectedin An alkylating agent approved for the treatment of unresectable or metastatic soft tissue sarcoma (liposarcoma or leiomyosarcoma). Tretoquinol Not Annotated Tubocurarine Tubocurarine is a non-depolarizing neuromuscular blocking agent and the first identified curare alkaloid. Curare is one of the names used to describe plant-derived poisons used by indigenous South Americans to... Zalypsis Zalypsis has been used in trials studying the treatment of Lymphoma, Solid Tumors, Ewing's Sarcoma, Endometrial Cancer, and Uterine Cervical Cancer, among others. Zelandopam Zelandopam is a small molecule drug. Zelandopam has a monoisotopic molecular weight of 273.1 Da. - Drugs & Drug Targets