Metocurine

DB01336ApprovedSmall molecule

Dimethyltubocurarinium (INN) or metocurine (USAN), also known as dimethyltubocurarine, is a non-depolarizing muscle relaxant. Patients on chronic anticonvulsant drugs are relatively resistant to metocurine.

Mechanism: Metocurine antagonizes the neurotransmitter action of acetylcholine by binding competitively with cholinergic receptor sites on the motor end-plate. This antagonism is inhibited, and neuromuscular block reversed, by acetylcholinesterase inhibitors such as neostigmine, edrophonium, and pyridostigmine.
Curator reviewed
Primary indication: Metocurine is a muscle relaxant.Curator reviewed
Formula / weight: C₄₀H₄₈N₂O₆ · 652.8189 g/mol (avg)
Also known as: Dimethylchondrocurarine
Code names: BRN 3583380

Resolves to

Compound

UNIIV0M92G2U26CAS5152-30-7ChEMBLCHEMBL1259ChEBI6900PubChem21233KEGGC07919

Clinical / RWD

RxNorm29950PharmGKBPA164749507

Structure

InChIKeyJFXBEKISTKFVAB-AJQTZOPKSA-NSMILES[H][C@@]12CC3=CC=C(OC4=C5C(CC[N+](C)(C)[C@]5([H])CC5=CC(OC6=C(OC)C=C(CC[N+]1(C)C)C2=C6)=C(OC)C=C5)=CC(OC)=C4OC)C=C3

Targets

Q15822CHRNA2P08172CHRM2

What you can answer from here — as of September 12, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

1,220Drug interactionsStructured to mechanism, not free text

7+ReferencesStructured and connected to the statements they support

Which drugs share a target with Metocurine, and which of those have an active Phase 3 trial?

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