Metocurine iodide is a benzylisoquinolinium competitive nondepolarizing neuromuscular blocking agent. It is used as an anesthesia adjunct to induce skeletal muscle relaxation and to reduce the intensity of muscle contractions... Metocurine iodide can be used most advantageously if muscle twitch response to peripheral nerve stimulation is monitored to assess degree of muscle relaxation.
- Mechanism
- Curator reviewed
Metocurine iodide antagonizes the neurotransmitter action of acetylcholine by binding competitively with cholinergic receptor sites on the motor end-plate. This antagonism is inhibited, and neuromuscular block reversed, by acetylcholinesterase inhibitors such as neostigmine, edrophonium, and pyridostigmine.
- Primary indication
- For use as an anesthesia adjunct to induce skeletal muscle relaxation and to reduce the intensity of muscle contractions in convulsive therapy.Curator reviewed
- Formula / weight
- C40H48I2N2O6 · 906.6279 g/mol (avg)
- First approval
- Canada, 1948
- Also known as
- Dimethyl tubocurarine iodide · Dimethylchondrocurarine iodide · Dimethyltubocurarinium iodide · Metubine iodide
- Code names
- NSC-36388
Resolves to
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Which drugs share a target with Metocurine iodide, and which of those have an active Phase 3 trial?
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