Naphthacenes

Name
Naphthacenes
Accession Number
DBCAT000617
Description

Polyacenes with four ortho-fused benzene rings in a straight linear arrangement. This group is best known for the subclass called TETRACYCLINES.

Drugs
DrugDrug Description
DoxycyclineA tetracycline antibiotic used to treat a wide variety of bacterial infections.
LymecyclineA tetracycline antibiotic used for the treatment of acne vulgaris and other susceptible infections.
ValrubicinAn anthracycline used intravesically in the treatment of BCG-resistant bladder carcinoma.
EpirubicinAn anthracycline topoisomerase II inhibitor used as an adjuvant to treating axillary node metastases in patients who have undergone surgical resection of primary breast cancer.
ClomocyclineFor the treatment and management of Brucellosis, mycoplasma infection, acne vulgaris, chlamydial infection;Chronic bronchitis
TigecyclineA glycylcycline antibiotic used to treat a number of susceptible bacterial infections.
OxytetracyclineA tetracycline antibiotic used to treat a wide variety of susceptible bacterial infections.
DemeclocyclineA tetracycline antibiotic used to treat a wide variety of susceptible bacterial infections.
DaunorubicinAn anthracycline aminoglycoside used to induce remission of nonlymphocytic leukemia and acute lymphocytic leukemia.
TetracyclineAn antibiotic used to treat a wide variety of susceptible infections.
MetacyclineFor the treatment of acute bacterial exacerbations of chronic bronchitis
DoxorubicinA medication used to treat various cancers and Kaposi's Sarcoma.
MinocyclineA tetracycline analog used to treat a wide variety of infections in the body.
IdarubicinAn anthracycline antineoplastic agent used to treat acute myeloid leukemia (AML) in adults.
RolitetracyclineA broad-spectrum tetracycline antibiotic used in cases needing high concentrations or when oral administration is impractical.
SP1049CIntended for the treatment of carcinoma of the oesophagus.
AldoxorubicinInvestigated for use/treatment in solid tumors.
AmrubicinInvestigated for use/treatment in lung cancer .
AnnamycinInvestigated for use/treatment in breast cancer and leukemia (unspecified).
PlicamycinFor the treatment of testicular cancer, as well as hypercalcemia and hypercalciuria associated with a variety of advanced forms of cancer.
ChlortetracyclineThe first tetracycline antibiotic most commonly used for veterinary purposes.
PirarubicinNot Annotated
AclarubicinNot Annotated
ZorubicinZorubicin is a drug of the anthracycline class - a class of medications that have historically demonstrated effective chemotherapy for a variety of cancer types.
EravacyclineA tetracycline antibiotic used to treat complicated intra-abdominal infections.
SabarubicinSabarubicin has been used in trials studying the treatment of Prostate Cancer, Testicular Germ Cell Tumor, and Unspecified Adult Solid Tumor, Protocol Specific.
OmadacyclineA tetracycline antibiotic used to treat community acquired bacterial pneumonia.
Zoptarelin doxorubicinZoptarelin doxorubicin has been used in trials studying the treatment of Breast Cancer, Ovarian Cancer, Prostate Cancer, Endometrial Cancer, and Urothelial Carcinoma, among others.
GPX-150GPX-150 has been used in trials studying the treatment of Soft Tissue Sarcoma and Advanced Solid Tumors - Phase 1 Population.
PenimepicyclinePenimepicycline is a tetracycline-class antibiotic. It is mentioned on List A produced by the Government of Canada, which is a list of antimicrobial active pharmaceutical ingredients . In the classification...
MeclocyclineCurrently under investigation for the topical treatment of ulcerative oral mucositis
DTS-201Investigated for use/treatment in cancer/tumors (unspecified).
SarecyclineA tetracycline antibiotic used to treat inflammatory lesions of non-nodular moderate to severe acne vulgaris.
GancotamabGancotamab is under investigation in clinical trial NCT02213744 (MM-302 Plus Trastuzumab vs. Chemotherapy of Physician's Choice Plus Trastuzumab in HER2-Positive Locally Advanced/Metastatic Breast Cancer Patients).
TP-271TP-271 is under investigation in clinical trial NCT02724085 (A Phase 1 Study to Assess the Safety, Tolerability and PK of IV TP-271).
IncyclinideIncyclinide has been used in trials studying the treatment of HIV Infection, AIDS-related Kaposi Sarcoma, Brain and Central Nervous System Tumors, and Unspecified Adult Solid Tumor, Protocol Specific.
Drugs & Drug Targets
DrugTargetType
Doxycycline16S ribosomal RNAtarget
DoxycyclineSolute carrier family 22 member 6transporter
DoxycyclineCytochrome P450 3A4enzyme
DoxycyclineATP-binding cassette sub-family B member 5transporter
Lymecycline30S ribosomal protein S4target
ValrubicinDNA topoisomerase 2-alphatarget
ValrubicinDNAtarget
EpirubicinDNA topoisomerase 2-alphatarget
EpirubicinDNAtarget
EpirubicinMultidrug resistance-associated protein 1transporter
EpirubicinUDP-glucuronosyltransferase 2B7enzyme
EpirubicinCytosolic phospholipase A2enzyme
Clomocycline30S ribosomal protein S4target
Clomocycline30S ribosomal protein S9target
Clomocycline16S ribosomal RNAtarget
Tigecycline30S ribosomal protein S9target
Tigecycline16S ribosomal RNAtarget
Tigecycline30S ribosomal protein S14target
Tigecycline30S ribosomal protein S13target
Tigecycline30S ribosomal protein S19target
Tigecycline30S ribosomal protein S12target
Oxytetracycline30S ribosomal protein S4target
Oxytetracycline30S ribosomal protein S9target
Oxytetracycline16S ribosomal RNAtarget
OxytetracyclineSolute carrier family 22 member 6transporter
OxytetracyclineSolute carrier family 22 member 8transporter
OxytetracyclineSolute carrier family 22 member 11transporter
OxytetracyclineSolute carrier family 22 member 7transporter
OxytetracyclineSerum albumincarrier
Demeclocycline30S ribosomal proteintarget
DemeclocyclineVasopressin V2 receptortarget
DaunorubicinDNAtarget
DaunorubicinXanthine dehydrogenase/oxidaseenzyme
DaunorubicinCytochrome P450 3A5enzyme
DaunorubicinNADPH--cytochrome P450 reductaseenzyme
DaunorubicinP-glycoprotein 1transporter
DaunorubicinMultidrug resistance-associated protein 1transporter
DaunorubicinCanalicular multispecific organic anion transporter 1transporter
DaunorubicinMultidrug resistance-associated protein 6transporter
DaunorubicinBile salt export pumptransporter
DaunorubicinMultidrug resistance-associated protein 7transporter
DaunorubicinATP-binding cassette sub-family G member 2transporter
DaunorubicinDNA topoisomerase 2-alphatarget
DaunorubicinDNA topoisomerase 2-betatarget
DaunorubicinCytochrome P450 1A1enzyme
DaunorubicinCytochrome P450 1B1enzyme
DaunorubicinCytochrome P450 3A4enzyme
Tetracycline16S ribosomal RNAtarget
TetracyclineMajor prion proteintarget
TetracyclineSerum albumincarrier
TetracyclineCytochrome P450 3A4enzyme
TetracyclineSolute carrier family 22 member 6transporter
TetracyclineSolute carrier family 22 member 8transporter
TetracyclineSolute carrier family 22 member 11transporter
TetracyclineSolute carrier family 22 member 7transporter
Tetracycline30S ribosomal protein S3target
Tetracycline30S ribosomal protein S8target
Tetracycline30S ribosomal protein S19target
Tetracycline30S ribosomal protein S14target
Tetracycline30S ribosomal protein S7target
TetracyclineMultidrug translocase MdfAtarget
TetracyclineProtein-arginine deiminase type-4target
TetracyclineSolute carrier organic anion transporter family member 2B1transporter
MetacyclineSerum albumincarrier
Metacycline16S ribosomal RNAtarget
DoxorubicinDNA topoisomerase 2-alphatarget
DoxorubicinDNAtarget
DoxorubicinCytochrome P450 3A4enzyme
DoxorubicinCytochrome P450 2D6enzyme
DoxorubicinCytochrome P450 2B6enzyme
DoxorubicinP-glycoprotein 1transporter
DoxorubicinCanalicular multispecific organic anion transporter 2transporter
DoxorubicinMultidrug resistance-associated protein 6transporter
DoxorubicinMultidrug resistance-associated protein 1transporter
DoxorubicinMultidrug resistance-associated protein 7transporter
DoxorubicinATP-binding cassette sub-family G member 2transporter
DoxorubicinBile salt export pumptransporter
DoxorubicinSolute carrier family 22 member 16transporter
DoxorubicinATP-binding cassette sub-family B member 8, mitochondrialtransporter
DoxorubicinCytochrome P450 1B1enzyme
DoxorubicinCarbonyl reductase [NADPH] 1enzyme
DoxorubicinCarbonyl reductase [NADPH] 3enzyme
DoxorubicinAlcohol dehydrogenase [NADP(+)]enzyme
DoxorubicinAldo-keto reductase family 1 member C3enzyme
DoxorubicinNAD(P)H dehydrogenase [quinone] 1enzyme
DoxorubicinXanthine dehydrogenase/oxidaseenzyme
DoxorubicinNitric oxide synthase, endothelialenzyme
DoxorubicinNitric oxide synthase, inducibleenzyme
DoxorubicinNitric oxide synthase, brainenzyme
DoxorubicinNADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrialenzyme
DoxorubicinNADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialenzyme
DoxorubicinNADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialenzyme
DoxorubicinNADPH--cytochrome P450 reductaseenzyme
DoxorubicinRalA-binding protein 1transporter
DoxorubicinCanalicular multispecific organic anion transporter 1transporter
DoxorubicinSerum albumincarrier
DoxorubicinNucleolar and coiled-body phosphoprotein 1target
Minocycline30S ribosomal protein S4target
Minocycline30S ribosomal protein S9target
Minocycline16S ribosomal RNAtarget
MinocyclineInterleukin-1 betatarget
MinocyclineArachidonate 5-lipoxygenasetarget
MinocyclineMatrix metalloproteinase-9target
MinocyclineVascular endothelial growth factor Atarget
MinocyclineCaspase-1target
MinocyclineCaspase-3target
MinocyclineCytochrome ctarget
MinocyclineSolute carrier family 22 member 6transporter
MinocyclineSolute carrier family 22 member 7transporter
MinocyclineOuter membrane protein Ftransporter
MinocyclineOuter membrane porin Ctransporter
MinocyclineMitogen-activated Protein Kinasestarget
MinocyclineNitric oxide synthase, inducibletarget
IdarubicinDNA topoisomerase 2-alphatarget
IdarubicinDNAtarget
IdarubicinMultidrug resistance-associated protein 1transporter
IdarubicinCytochrome P450 2C9enzyme
IdarubicinCytochrome P450 2D6enzyme
Rolitetracycline30S ribosomal protein S9target
Rolitetracycline16S ribosomal RNAtarget
SP1049CDNA topoisomerase 2-alphatarget
AldoxorubicinDNA topoisomerase 2-alphatarget
AmrubicinDNA topoisomerase 2-alphatarget
AmrubicinDNAtarget
AmrubicinNADPH--cytochrome P450 reductaseenzyme
AmrubicinCarbonyl reductase [NADPH] 1enzyme
AmrubicinATP-binding cassette sub-family B member 5transporter
AnnamycinDNA topoisomerase 2-alphatarget
AnnamycinDNAtarget
AnnamycinP-glycoprotein 1transporter
PlicamycinDNAtarget
Chlortetracycline16S ribosomal RNAtarget
ChlortetracyclineSerum albumincarrier
Chlortetracycline30S ribosomal protein S3target
Chlortetracycline30S ribosomal protein S8target
Chlortetracycline30S ribosomal protein S19target
Chlortetracycline30S ribosomal protein S14target
Chlortetracycline30S ribosomal protein S7target
EravacyclineCytochrome P450 3A4enzyme
EravacyclineAmine oxidase [flavin-containing] Aenzyme
Eravacycline30S ribosomal protein S4target
OmadacyclineP-glycoprotein 1transporter
Omadacycline30S ribosomal protein S3target
Omadacycline30S ribosomal protein S7target
Omadacycline30S ribosomal protein S8target
Omadacycline30S ribosomal protein S19target
Omadacycline30S ribosomal protein S14target
Omadacycline16S ribosomal RNAtarget
OmadacyclineSerum albumincarrier
MeclocyclineOuter membrane protein Ftransporter
MeclocyclineOuter membrane porin Ctransporter
Meclocycline30S ribosomal protein S7target
MeclocyclineTetX family tetracycline inactivation enzymeenzyme
SarecyclineP-glycoprotein 1transporter