Antipruritics

Name
Antipruritics
Accession Number
DBCAT000666
Description

Agents, usually topical, that relieve itching (pruritus).

Drugs
DrugDrug Description
ClemastineAn antihistamine with sedative and anticholinergic effects used to treat the symptoms of allergic rhinitis.
CyproheptadineA combined serotonin and histamine antagonist used in the treatment of allergic symptoms, for appetite stimulation, and off-label in the treatment of serotonin syndrome.
LoratadineA second generation antihistamine used to manage the symptoms of allergic rhinitis.
HydroxyzineAn antihistamine used to treat anxiety and tension associated with psychoneuroses, as well as allergic conditions such as pruritus and chronic urticaria.
KetotifenA histamine H1 receptor blocker and mast cell stabilizer used to treat mild atopic asthma and allergic conjunctivitis.
PromethazineA first-generation antihistamine used for the treatment of allergic conditions, nausea and vomiting, and motion sickness.
ChlorpheniramineA histamine-H1 receptor antagonist indicated for the management of symptoms associated with upper respiratory allergies.
AlimemazineAn antihistamine agent used to prevent and relieve allergic conditions which cause pruritus and other allergic skin conditions, including urticaria.
PheniramineAn antihistamine used to treat allergic rhinitis and pruritus.
NalmefeneAn opioid antagonist used in conjunction with psychosocial support to help adults with alcohol dependence reduce alcohol consumption.
CapsaicinA topical analgesic agent used for the symptomatic relief of neuropathic pain associated with post-herpetic neuralgia, as well as other muscle and joint pain.
DimetindeneA 1st generation selective H1 antagonist used topically as an antipruritic and orally to treat allergies.
E-6005E6005 has been used in trials studying the treatment of Atopic Dermatitis.
LevomentholAn organic compound used to treat mild to moderate muscle and joint pain.
Drugs & Drug Targets
DrugTargetType
ClemastineHistamine H1 receptortarget
ClemastineCytochrome P450 2D6enzyme
Cyproheptadine5-hydroxytryptamine receptor 2Atarget
CyproheptadineHistamine H1 receptortarget
CyproheptadineMuscarinic acetylcholine receptor M1target
CyproheptadineMuscarinic acetylcholine receptor M2target
CyproheptadineMuscarinic acetylcholine receptor M3target
Cyproheptadine5-hydroxytryptamine receptor 2Ctarget
CyproheptadineUDP-glucuronosyltransferase 1-3enzyme
Cyproheptadine5-hydroxytryptamine receptor 7target
CyproheptadineUDP-glucuronosyltransferase 2B10enzyme
CyproheptadineUDP-glucuronosyltransferase 1-4enzyme
Cyproheptadine5-hydroxytryptamine receptor 2Btarget
CyproheptadineHistamine H2 receptortarget
CyproheptadineSolute carrier family 22 member 1transporter
CyproheptadineSerum albumincarrier
LoratadineHistamine H1 receptortarget
LoratadineCytochrome P450 3A4enzyme
LoratadineCytochrome P450 2C19enzyme
LoratadineCytochrome P450 2D6enzyme
LoratadineCytochrome P450 2C8enzyme
LoratadineP-glycoprotein 1transporter
LoratadinePotassium voltage-gated channel subfamily H member 2target
LoratadineBile salt export pumptransporter
LoratadineCytochrome P450 1A1enzyme
LoratadineCytochrome P450 1A2enzyme
LoratadineCytochrome P450 2B6enzyme
LoratadineCytochrome P450 2C9enzyme
LoratadineCytochrome P450 3A5enzyme
LoratadineUDP-glucuronosyltransferase 2B10enzyme
LoratadineUDP-glucuronosyltransferase 1-1enzyme
LoratadineUDP-glucuronosyltransferase 1-3enzyme
LoratadineUDP-glucuronosyltransferase 2B15enzyme
HydroxyzineHistamine H1 receptortarget
HydroxyzineCytochrome P450 2D6enzyme
HydroxyzineCytochrome P450 3A4enzyme
HydroxyzineCytochrome P450 3A5enzyme
HydroxyzinePotassium voltage-gated channel subfamily H member 2target
HydroxyzineP-glycoprotein 1transporter
HydroxyzineSerum albumincarrier
KetotifenHistamine H1 receptortarget
Ketotifen6-phosphogluconate dehydrogenase, decarboxylatingtarget
KetotifenUDP-glucuronosyltransferase 1-3enzyme
KetotifenUDP-glucuronosyltransferase 1-4enzyme
KetotifenUDP-glucuronosyltransferase 2B10enzyme
PromethazineDopamine D2 receptortarget
PromethazineHistamine H1 receptortarget
PromethazineMuscarinic acetylcholine receptor M4target
PromethazineMuscarinic acetylcholine receptor M1target
PromethazineMuscarinic acetylcholine receptor M5target
PromethazineMuscarinic acetylcholine receptor M2target
PromethazineMuscarinic acetylcholine receptor M3target
PromethazineCalmodulintarget
PromethazineCytochrome P450 2D6enzyme
PromethazineCytochrome P450 2B6enzyme
PromethazineP-glycoprotein 1transporter
PromethazineCytochrome P450 2C9enzyme
PromethazineHistamine H2 receptortarget
PromethazineAlpha adrenergic receptortarget
PromethazineP2 Purinoceptorstarget
PromethazineVoltage-gated sodium channel alpha subunittarget
PromethazineVoltage-gated Potassium Channelstarget
PromethazineCanalicular multispecific organic anion transporter 2transporter
PromethazineMultidrug resistance-associated protein 4transporter
PromethazineSerum albumincarrier
ChlorpheniramineHistamine H1 receptortarget
ChlorpheniramineCytochrome P450 3A4enzyme
ChlorpheniramineCytochrome P450 2D6enzyme
ChlorpheniramineSodium-dependent serotonin transportertarget
ChlorpheniramineSodium-dependent noradrenaline transportertarget
ChlorpheniramineSodium-dependent dopamine transportertarget
ChlorpheniramineCytochrome P450 3A5enzyme
ChlorpheniramineCytochrome P450 3A7enzyme
ChlorpheniramineSolute carrier family 22 member 2transporter
ChlorpheniramineSolute carrier family 22 member 1transporter
AlimemazineHistamine H1 receptortarget
PheniramineHistamine H1 receptortarget
PheniramineNuclear receptor subfamily 1 group I member 3target
PheniramineHistamine H4 receptortarget
NalmefeneMu-type opioid receptortarget
NalmefeneKappa-type opioid receptortarget
NalmefeneDelta-type opioid receptortarget
NalmefeneUDP-glucuronosyltransferase 2B7enzyme
NalmefeneUDP-glucuronosyltransferase 1-3enzyme
NalmefeneUDP-glucuronosyltransferase 1-8enzyme
CapsaicinCytochrome P450 3A4enzyme
CapsaicinProstaglandin G/H synthase 2enzyme
CapsaicinMyeloperoxidaseenzyme
CapsaicinCytochrome P450 1A2enzyme
CapsaicinCytochrome P450 2E1enzyme
CapsaicinAmine oxidase [flavin-containing] Aenzyme
CapsaicinDopamine beta-hydroxylaseenzyme
CapsaicinGlutamine synthetaseenzyme
CapsaicinCholinesteraseenzyme
CapsaicinTransient receptor potential cation channel subfamily V member 1target
CapsaicinProhibitin-2target
DimetindeneMuscarinic acetylcholine receptor M2target
DimetindeneHistamine H1 receptortarget
LevomentholTransient receptor potential cation channel subfamily A member 1target
LevomentholTransient receptor potential cation channel subfamily M member 8target
LevomentholTransient receptor potential cation channel subfamily V member 3target
LevomentholKappa-type opioid receptortarget
LevomentholVoltage-dependent L-type calcium channeltarget
LevomentholCytochrome P450 3A4enzyme