Phenanthrenes

Name
Phenanthrenes
Accession Number
DBCAT000691
Description

POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.

Drugs
DrugDrug Description
MorphineAn opioid agonist used for the relief of moderate to severe acute and chronic pain.
CodeineAn opioid analgesic used to treat moderate to severe pain when the use of an opioid is indicated.
HydromorphoneAn opioid analgesic used to treat moderate to severe pain when the use of an opioid is indicated.
OxycodoneAn opioid used in the management of moderate to severe pain.
LevallorphanFor the complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids.
DextromethorphanAn NMDA receptor antagonist used to treat cases of dry cough.
ButorphanolAn opioid agonist-antagonist used to treat moderate to severe pain.
PentazocineAn analgesic used to treat moderate to severe pain.
NaltrexoneA narcotic antagonist used in opioid overdose.
NalbuphineAn opioid agonist-antagonist used to treat pain, for pre and postoperative analgesia, and for analgesia in labor and delivery.
LevorphanolAn opioid analgesic used to treat moderate to severe pain.
BuprenorphineA partial opioid agonist used for management of severe pain that is not responsive to alternative treatments. Also used for maintenance treatment of opioid addiction.
NaloxoneAn opioid receptor antagonist used to rapidly reverse an opioid overdose. Also included in some drug formulations as an abuse deterrent to prevent injection.
OxymorphoneAn opioid analgesic used in the management of moderate-to-severe pain and for analgesic therapies.
5-Methoxy-N,N-diisopropyltryptamine5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) is a tryptamine derivative and shares many similarities with schedule I tryptamine hallucinogens such as alpha-ethyltryptamine, N,N-dimethyltryptamine, N,N-diethyltryptamine, bufotenine, psilocybin and psilocin. Since 1999, there has been a...
DihydroetorphineNot Available
DiamorphineAn opioid analgesic agent used in the relief of severe pain associated with surgical procedures, myocardial infarction or pain in the terminally ill and for the relief of dyspnea in acute pulmonary edema.
EthylmorphineEthylmorphine is an analgesic used for pain relief.
CyprenorphineNot Available
EtorphineEtorphine is only available for its use in veterinary. This main usage is related to the immobilization of large mammals.
DesomorphineNot Available
DrotebanolNot Available
DiprenorphineDiprenorphine is indicated to reverse the effects of powerful opioids including etorphine and carfentanil, often used for tranquilizing large animals. This drug is not approved for use in humans.
DihydrocodeineAn opioid analgesic agent used for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.
DihydromorphineDihydromorphine is an opioid analgesic used for moderate to severe pain relief.
EcabetFor the treatment of reflux oesophagitis and peptic ulcer disease.
NalmefeneAn opioid antagonist used in conjunction with psychosocial support to help adults with alcohol dependence reduce alcohol consumption.
MethylnaltrexoneA μ-opioid antagonist used for the treatment of opioid-induced constipation in palliative patients that are inadequately responding to laxative therapy.
NaloxegolA peripherally-selective opioid antagonist used to treat opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain.
PholcodinePholcodine is indicated as a cough suppressant for the temporary relief of non-productive dry cough. It is stated to present a required label indication of "temporary relief of dry cough."...
NalorphineUsed to reverse opioid overdose.
SamidorphanSamidorphan has been used in trials studying the treatment of Schizophrenia, Alcohol Dependence, and Binge Eating Disorder.
NicomorphineNot Annotated
NalfurafineNot Annotated
PhenazocineNot Annotated
DimemorfanNot Annotated
DextrorphanNot Annotated
Morphine glucuronideInvestigated for use/treatment in pain (acute or chronic).
NaldemedineAn opioid antagonist used to to treat opioid-induced constipation.
LoxicodegolLoxicodegol was developed as an opioid analgesic with low abuse potential for use in treating chronic pain . An application has been filed for FDA approval of Loxicodegol for use...
Drugs & Drug Targets
DrugTargetType
MorphineMu-type opioid receptortarget
MorphineDelta-type opioid receptortarget
MorphineKappa-type opioid receptortarget
MorphineP-glycoprotein 1transporter
MorphineCytochrome P450 2C8enzyme
MorphineCytochrome P450 3A4enzyme
MorphineUDP-glucuronosyltransferase 2B7enzyme
MorphineUDP-glucuronosyltransferase 1-1enzyme
MorphineUDP-glucuronosyltransferase 1-8enzyme
MorphineUDP-glucuronosyltransferase 2B15enzyme
MorphineUDP-glucuronosyltransferase 2B4enzyme
MorphineUDP-glucuronosyltransferase 1-3enzyme
MorphineLymphocyte antigen 96target
MorphineSerum albumincarrier
CodeineMu-type opioid receptortarget
CodeineDelta-type opioid receptortarget
CodeineKappa-type opioid receptortarget
CodeineCytochrome P450 2D6enzyme
CodeineCytochrome P450 3A4enzyme
CodeineSolute carrier family 22 member 1transporter
CodeineUDP-glucuronosyltransferase 2B7enzyme
CodeineUDP-glucuronosyltransferase 2B4enzyme
HydromorphoneMu-type opioid receptortarget
HydromorphoneDelta-type opioid receptortarget
HydromorphoneKappa-type opioid receptortarget
HydromorphoneCytochrome P450 2C9enzyme
HydromorphoneUDP-glucuronosyltransferase 1-3enzyme
HydromorphoneUDP-glucuronosyltransferase 2B7enzyme
HydromorphoneSerum albumincarrier
OxycodoneMu-type opioid receptortarget
OxycodoneKappa-type opioid receptortarget
OxycodoneDelta-type opioid receptortarget
OxycodoneCytochrome P450 2D6enzyme
OxycodoneCytochrome P450 3A4enzyme
OxycodoneCytochrome P450 3A5enzyme
OxycodoneSerum albumincarrier
Oxycodonealpha1-acid glycoproteincarrier
LevallorphanMu-type opioid receptortarget
DextromethorphanSigma non-opioid intracellular receptor 1target
DextromethorphanHCG20471, isoform CRA_ctarget
DextromethorphanNeuronal acetylcholine receptor subunit alpha-2target
DextromethorphanSodium-dependent serotonin transportertarget
DextromethorphanGlutamate receptor ionotropic, NMDA 3Atarget
DextromethorphanCytochrome P450 2D6enzyme
DextromethorphanCytochrome P450 3A4enzyme
DextromethorphanCytochrome P450 3A7enzyme
DextromethorphanCytochrome P450 2C9enzyme
DextromethorphanCytochrome P450 2B6enzyme
DextromethorphanCytochrome P450 2C19enzyme
DextromethorphanMembrane-associated progesterone receptor component 1target
DextromethorphanNeuronal acetylcholine receptor subunit alpha-3target
DextromethorphanNeuronal acetylcholine receptor subunit alpha-4target
DextromethorphanNeuronal acetylcholine receptor subunit beta-4target
DextromethorphanNeuronal acetylcholine receptor subunit beta-2target
DextromethorphanNeuronal acetylcholine receptor subunit alpha-7target
DextromethorphanMu-type opioid receptortarget
DextromethorphanDelta-type opioid receptortarget
DextromethorphanKappa-type opioid receptortarget
DextromethorphanNADPH oxidasetarget
DextromethorphanSodium-dependent noradrenaline transportertarget
DextromethorphanUDP-glucuronosyltransferase 2B4enzyme
DextromethorphanUDP-glucuronosyltransferase 2B7enzyme
DextromethorphanUDP-glucuronosyltransferase 2B15enzyme
DextromethorphanUDP-glucuronosyltransferase 2B17enzyme
ButorphanolKappa-type opioid receptortarget
ButorphanolMu-type opioid receptortarget
ButorphanolDelta-type opioid receptortarget
PentazocineMu-type opioid receptortarget
PentazocineKappa-type opioid receptortarget
PentazocineSigma non-opioid intracellular receptor 1target
PentazocineP-glycoprotein 1transporter
NaltrexoneMu-type opioid receptortarget
NaltrexoneKappa-type opioid receptortarget
NaltrexoneDelta-type opioid receptortarget
NaltrexoneHCG20471, isoform CRA_ctarget
NaltrexoneUDP-glucuronosyltransferase 1-1enzyme
NalbuphineKappa-type opioid receptortarget
NalbuphineMu-type opioid receptortarget
NalbuphineDelta-type opioid receptortarget
LevorphanolMu-type opioid receptortarget
LevorphanolDelta-type opioid receptortarget
LevorphanolKappa-type opioid receptortarget
BuprenorphineKappa-type opioid receptortarget
BuprenorphineMu-type opioid receptortarget
BuprenorphineCytochrome P450 3A4enzyme
BuprenorphineCytochrome P450 2D6enzyme
BuprenorphineP-glycoprotein 1transporter
BuprenorphineATP-binding cassette sub-family G member 2transporter
BuprenorphineCytochrome P450 2C9enzyme
BuprenorphineCytochrome P450 3A5enzyme
BuprenorphineCytochrome P450 2C8enzyme
BuprenorphineCytochrome P450 3A7enzyme
BuprenorphineDelta-type opioid receptortarget
BuprenorphineCytochrome P450 2C18enzyme
BuprenorphineCytochrome P450 2C19enzyme
BuprenorphineNociceptin receptortarget
NaloxoneMu-type opioid receptortarget
NaloxoneEstrogen receptor alphatarget
NaloxoneCyclic AMP-responsive element-binding protein 1target
NaloxoneDelta-type opioid receptortarget
NaloxoneSolute carrier organic anion transporter family member 1A2transporter
NaloxoneP-glycoprotein 1transporter
NaloxoneKappa-type opioid receptortarget
NaloxoneCytochrome P450 3A4enzyme
NaloxoneSerum albumincarrier
NaloxoneToll-like receptor 4target
NaloxoneLiver carboxylesterase 1target
NaloxoneUDP-glucuronosyltransferase 1-1enzyme
OxymorphoneMu-type opioid receptortarget
OxymorphoneCytochrome P450 2D6enzyme
OxymorphoneDelta-type opioid receptortarget
OxymorphoneCytochrome P450 3A4enzyme
DiamorphineMu-type opioid receptortarget
DiamorphineKappa-type opioid receptortarget
DiamorphineDelta-type opioid receptortarget
DiamorphineLiver carboxylesterase 1target
DiamorphineThyroxine-binding globulincarrier
EthylmorphineCytochrome P450 2D6enzyme
EthylmorphineNADPH--cytochrome P450 reductaseenzyme
EthylmorphineMu-type opioid receptortarget
EthylmorphineCytochrome P450 2B6enzyme
EthylmorphineCytochrome P450 3A4enzyme
EtorphineE3 ubiquitin-protein ligase TRIM13target
EtorphinePro-opiomelanocortintarget
EtorphineMu-type opioid receptortarget
EtorphineDelta-type opioid receptortarget
EtorphineKappa-type opioid receptortarget
EtorphineNociceptin receptortarget
DiprenorphineE3 ubiquitin-protein ligase TRIM13target
DiprenorphineDelta-type opioid receptortarget
DiprenorphineKappa-type opioid receptortarget
DiprenorphineMu-type opioid receptortarget
DihydrocodeineCytochrome P450 2D6enzyme
DihydrocodeineCytochrome P450 3A4enzyme
DihydromorphineE3 ubiquitin-protein ligase TRIM13target
DihydromorphinePro-opiomelanocortintarget
DihydromorphineMu-type opioid receptortarget
DihydromorphineDelta-type opioid receptortarget
DihydromorphineKappa-type opioid receptortarget
EcabetNADPH oxidase organizer 1target
EcabetUrease subunit alphatarget
NalmefeneMu-type opioid receptortarget
NalmefeneKappa-type opioid receptortarget
NalmefeneDelta-type opioid receptortarget
NalmefeneUDP-glucuronosyltransferase 2B7enzyme
NalmefeneUDP-glucuronosyltransferase 1-3enzyme
NalmefeneUDP-glucuronosyltransferase 1-8enzyme
MethylnaltrexoneMu-type opioid receptortarget
MethylnaltrexoneKappa-type opioid receptortarget
NaloxegolCytochrome P450 3A4enzyme
NaloxegolCytochrome P450 2D6enzyme
NaloxegolCytochrome P450 2C19enzyme
NaloxegolMu-type opioid receptortarget
PholcodineMu-type opioid receptortarget
PholcodineKappa-type opioid receptortarget
PholcodineDelta-type opioid receptortarget
Morphine glucuronideMu-type opioid receptortarget
Morphine glucuronideDelta-type opioid receptortarget
Morphine glucuronideKappa-type opioid receptortarget
NaldemedineCytochrome P450 3A Subfamilyenzyme
NaldemedineUDP-glucuronosyltransferase 1-3enzyme
NaldemedineMu-type opioid receptortarget
NaldemedineDelta-type opioid receptortarget
NaldemedineKappa-type opioid receptortarget
NaldemedineATP-binding cassette sub-family B member 5transporter
LoxicodegolMu-type opioid receptortarget
LoxicodegolDelta-type opioid receptortarget
LoxicodegolKappa-type opioid receptortarget
LoxicodegolP-glycoprotein 1transporter