Pregnenediones

Name
Pregnenediones
Accession Number
DBCAT000827
Description

Unsaturated pregnane derivatives containing two keto groups on side chains or ring structures.

Drugs
DrugDrug Description
ProgesteroneA hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia.
Medroxyprogesterone acetateA progestin used as a contraceptive and in the treatment of secondary amenorrhea, abnormal uterine bleeding, pain from endometriosis, endometrial and renal carcinomas, paraphilia in males, and GnRH-dependent precocious puberty.
HydrocortisoneA glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders.
FlurandrenolideA corticosteroid used to treat corticosteroid-responsive dermatoses.
BudesonideA corticosteroid used to treat Crohn's disease, asthma, COPD, hay fever and allergies, and ulcerative colitis.
CorticosteroneAn adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)
HalcinonideA corticosteroid used for the management and symptomatic relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
ClascoteroneAn androgen receptor antagonist used for the topical treatment of acne vulgaris in patients 12 years of age and older.
DesoxycortoneNot Annotated
AldosteroneA hormone secreted by the adrenal cortex that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.
Gestonorone caproateNot Annotated
Desoxycorticosterone pivalateExamined for treatment of adrenocortical insufficiency especially in multiple sclerosis, congenital cerebral palsy, polyarteritis nodosa, and rheumatoid arthritis. Currently only approved in treating cats and dogs for the treatment of...
Anecortave acetateInvestigated for use/treatment in glaucoma and macular degeneration.
NCX 1022Investigated for use/treatment in atopic dermatitis.
Desoxycorticosterone acetateNot Annotated
Hydroxyprogesterone caproateA synthetic progestin used for the prevention of spontaneous preterm births in singleton pregnancies in women who have previously had a spontaneous preterm birth.
TixocortolA corticosteroid used for the symptomatic treatment of rhinitis, pharyngitis, and ulcerative colitis.
BrexanoloneBrexanolone is a synthetic neuroactive steroid gamma-aminobutyric acid A (GABA(a)) receptor positive modulator indicated for the treatment of postpartum depression (PPD) in adult women [FDA Label][A176080, A176083, F4063, F4066, F4072].
AnecortaveAnecortave is under investigation in clinical trial NCT00691717 (Anecortave Acetate Safety in Patients With Open-Angle Glaucoma or Ocular Hypertension).
FlumedroxoneNot Annotated
Hydrocortisone aceponateFor the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many...
Hydrocortisone acetateA corticosteroid used to treat inflammatory and pruritic corticosteroid-responsive dermatoses and ulcerative colitis.
Hydrocortisone butyrateA corticosteroid used to treat inflammatory and pruritic corticosteroid-responsive dermatoses.
Hydrocortisone cypionateFor the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many...
Hydrocortisone phosphateA corticosteroid used to treat congenital adrenal hyperplasia, for emergency asthma treatment, hypersensitivity, and inflammation.
Hydrocortisone probutateA corticosteroid used to treat inflammatory and pruritic corticosteroid-responsive dermatoses.
Hydrocortisone valerateA corticosteroid used to treat inflammatory and pruritic corticosteroid-responsive dermatoses.
Hydrocortisone succinateA corticosteroid used to treat severe allergic reactions, dermatologic diseases, endocrine disorders, gastrointestinal diseases, hematological disorders, neoplastic diseases, nervous system conditions, ophthalmic diseases, renal diseases, respiratory diseases, and rheumatic disorders.
HydroxyprogesteroneNot Annotated
Algestone acetophenideA progestin indicated in combination with an estrogen as an injectable contraceptive.
AlgestoneNot Available
Drugs & Drug Targets
DrugTargetType
ProgesteroneProgesterone receptortarget
ProgesteroneEstrogen receptor alphatarget
ProgesteroneSteroid 17-alpha-hydroxylase/17,20 lyasetarget
ProgesteroneCytochrome P450 2C19enzyme
ProgesteroneCytochrome P450 2C9enzyme
ProgesteroneCytochrome P450 3A4enzyme
ProgesteroneCytochrome P450 3A5enzyme
ProgesteroneCytochrome P450 3A7enzyme
ProgesteroneP-glycoprotein 1transporter
ProgesteroneSolute carrier family 22 member 2transporter
ProgesteroneSolute carrier family 22 member 1transporter
ProgesteroneSolute carrier family 22 member 3transporter
ProgesteroneBile salt export pumptransporter
ProgesteroneMultidrug resistance-associated protein 1transporter
ProgesteroneSodium/bile acid cotransportertransporter
ProgesteroneSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
ProgesteroneCytochrome P450 1A1enzyme
ProgesteroneCytochrome P450 1B1enzyme
ProgesteroneCytochrome P450 2A6enzyme
ProgesteroneCytochrome P450 2D6enzyme
ProgesteroneMineralocorticoid receptortarget
ProgesteroneKappa-type opioid receptortarget
ProgesteroneAlpha-1-acid glycoprotein 1target
ProgesteroneGlucocorticoid receptortarget
ProgesteroneAndrogen receptortarget
ProgesteroneSex hormone-binding globulintarget
ProgesteroneSolute carrier organic anion transporter family member 1B1transporter
ProgesteroneATP-binding cassette sub-family G member 2transporter
ProgesteroneEstrogen receptor betatarget
ProgesteroneSolute carrier organic anion transporter family member 1B3transporter
Medroxyprogesterone acetateProgesterone receptortarget
Medroxyprogesterone acetateEstrogen receptor alphatarget
Medroxyprogesterone acetateCytochrome P450 3A4enzyme
Medroxyprogesterone acetateCytochrome P450 2C8enzyme
Medroxyprogesterone acetate3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2enzyme
Medroxyprogesterone acetateCytochrome P450 2C9enzyme
Medroxyprogesterone acetateCytochrome P450 3A1enzyme
Medroxyprogesterone acetateSerum albumincarrier
Medroxyprogesterone acetateP-glycoprotein 1target
Medroxyprogesterone acetateGABA(A) Receptortarget
Medroxyprogesterone acetateP-glycoprotein 1transporter
HydrocortisoneAnnexin A1target
HydrocortisoneGlucocorticoid receptortarget
HydrocortisoneSex hormone-binding globulincarrier
HydrocortisoneCytochrome P450 3A4enzyme
HydrocortisoneCytochrome P450 3A5enzyme
HydrocortisoneCytochrome P450 3A7enzyme
HydrocortisoneP-glycoprotein 1transporter
HydrocortisoneSolute carrier organic anion transporter family member 1A2transporter
HydrocortisoneCytochrome P450 11B1, mitochondrialenzyme
HydrocortisoneCytochrome P450 11B2, mitochondrialenzyme
HydrocortisoneCytochrome P450 2C8enzyme
HydrocortisoneCorticosteroid-binding globulincarrier
HydrocortisoneSolute carrier family 22 member 8transporter
Hydrocortisone3-oxo-5-beta-steroid 4-dehydrogenaseenzyme
Hydrocortisone3-oxo-5-alpha-steroid 4-dehydrogenase 2enzyme
HydrocortisoneCorticosteroid 11-beta-dehydrogenase isozyme 2enzyme
HydrocortisoneCorticosteroid 11-beta-dehydrogenase isozyme 1enzyme
HydrocortisoneCytochrome P450 2A6enzyme
HydrocortisoneCytochrome P450 1B1enzyme
HydrocortisoneCytochrome P450 2B6enzyme
HydrocortisoneCytochrome P450 2C9enzyme
HydrocortisoneCytochrome P450 2C19enzyme
FlurandrenolideCorticosteroid-binding globulincarrier
FlurandrenolideGlucocorticoid receptortarget
FlurandrenolideCytochrome P450 3A4enzyme
BudesonideGlucocorticoid receptortarget
BudesonideCytochrome P450 3A4enzyme
BudesonideCytochrome P450 3A5enzyme
BudesonideBile salt export pumptransporter
BudesonideP-glycoprotein 1transporter
BudesonideAnnexin A1target
BudesonideCytochrome P450 3A Subfamilyenzyme
BudesonideCytochrome P450 2A6enzyme
BudesonideCytochrome P450 1B1enzyme
BudesonideCytochrome P450 2B6enzyme
BudesonideCytochrome P450 2C8enzyme
BudesonideCytochrome P450 2C9enzyme
BudesonideCytochrome P450 2C19enzyme
BudesonideCorticosteroid-binding globulincarrier
BudesonideSolute carrier organic anion transporter family member 1A2transporter
BudesonideSolute carrier family 22 member 8transporter
BudesonideSerum albumincarrier
CorticosteroneMineralocorticoid receptortarget
CorticosteroneCorticosteroid 11-beta-dehydrogenase isozyme 1target
CorticosteroneNuclear receptor coactivator 1target
CorticosteroneCytochrome P450 3A4enzyme
CorticosteroneCorticosteroid 11-beta-dehydrogenase isozyme 1enzyme
CorticosteroneCorticosteroid 11-beta-dehydrogenase isozyme 2enzyme
HalcinonideSmoothened homologtarget
HalcinonideCytochrome P450 3A4enzyme
ClascoteroneAndrogen receptortarget
ClascoteroneCytochrome P450 1A2enzyme
ClascoteroneCytochrome P450 2B6enzyme
ClascoteroneCytochrome P450 2C8enzyme
ClascoteroneCytochrome P450 2C9enzyme
ClascoteroneCytochrome P450 2C19enzyme
ClascoteroneCytochrome P450 2D6enzyme
ClascoteroneCytochrome P450 2E1enzyme
ClascoteroneCytochrome P450 3A4enzyme
AldosteroneMineralocorticoid receptortarget
AldosteroneP-glycoprotein 1transporter
AldosteroneSolute carrier family 22 member 5transporter
AldosteroneSolute carrier organic anion transporter family member 1A2transporter
AldosteroneCytochrome P450 11B1, mitochondrialenzyme
AldosteroneCytochrome P450 11B2, mitochondrialenzyme
AldosteroneSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
AldosteroneGlucocorticoid receptortarget
AldosteroneCytochrome P450 3A4enzyme
Desoxycorticosterone pivalateMineralocorticoid receptortarget
Desoxycorticosterone pivalateCytochrome P450 3A4enzyme
Desoxycorticosterone acetateMineralocorticoid receptortarget
Desoxycorticosterone acetateCytochrome P450 3A4enzyme
Hydroxyprogesterone caproateProgesterone receptortarget
Hydroxyprogesterone caproateCytochrome P450 3A4enzyme
Hydroxyprogesterone caproateCytochrome P450 3A5enzyme
Hydroxyprogesterone caproateCytochrome P450 2C19enzyme
TixocortolGlucocorticoid receptortarget
TixocortolHistone deacetylase 2target
BrexanoloneGABA(A) Receptortarget
BrexanoloneAldose reductaseenzyme
Hydrocortisone aceponateAnnexin A1target
Hydrocortisone aceponateGlucocorticoid receptortarget
Hydrocortisone aceponateSex hormone-binding globulincarrier
Hydrocortisone aceponateCytochrome P450 3A4enzyme
Hydrocortisone aceponateCytochrome P450 3A5enzyme
Hydrocortisone aceponateCytochrome P450 3A7enzyme
Hydrocortisone aceponateP-glycoprotein 1transporter
Hydrocortisone aceponateSolute carrier organic anion transporter family member 1A2transporter
Hydrocortisone aceponateATP-binding cassette sub-family G member 2transporter
Hydrocortisone aceponateCytochrome P450 2C8enzyme
Hydrocortisone aceponateCorticosteroid-binding globulincarrier
Hydrocortisone aceponateCorticosteroid 11-beta-dehydrogenase isozyme 2target
Hydrocortisone aceponate3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
Hydrocortisone aceponateSolute carrier family 22 member 8transporter
Hydrocortisone acetateAnnexin A1target
Hydrocortisone acetateGlucocorticoid receptortarget
Hydrocortisone acetateSex hormone-binding globulincarrier
Hydrocortisone acetateCytochrome P450 3A4enzyme
Hydrocortisone acetateCytochrome P450 3A5enzyme
Hydrocortisone acetateCytochrome P450 3A7enzyme
Hydrocortisone acetateP-glycoprotein 1transporter
Hydrocortisone acetateSolute carrier organic anion transporter family member 1A2transporter
Hydrocortisone acetateATP-binding cassette sub-family G member 2transporter
Hydrocortisone acetateCytochrome P450 11B1, mitochondrialenzyme
Hydrocortisone acetateCytochrome P450 11B2, mitochondrialenzyme
Hydrocortisone acetateCytochrome P450 2C8enzyme
Hydrocortisone acetateCorticosteroid-binding globulincarrier
Hydrocortisone acetateCorticosteroid 11-beta-dehydrogenase isozyme 2target
Hydrocortisone acetate3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
Hydrocortisone acetateSolute carrier family 22 member 8transporter
Hydrocortisone butyrateAnnexin A1target
Hydrocortisone butyrateGlucocorticoid receptortarget
Hydrocortisone butyrateSex hormone-binding globulincarrier
Hydrocortisone butyrateCytochrome P450 3A4enzyme
Hydrocortisone butyrateCytochrome P450 3A5enzyme
Hydrocortisone butyrateCytochrome P450 3A7enzyme
Hydrocortisone butyrateP-glycoprotein 1transporter
Hydrocortisone butyrateSolute carrier organic anion transporter family member 1A2transporter
Hydrocortisone butyrateATP-binding cassette sub-family G member 2transporter
Hydrocortisone butyrateCytochrome P450 11B1, mitochondrialenzyme
Hydrocortisone butyrateCytochrome P450 11B2, mitochondrialenzyme
Hydrocortisone butyrateCytochrome P450 2C8enzyme
Hydrocortisone butyrateCorticosteroid-binding globulincarrier
Hydrocortisone butyrateCorticosteroid 11-beta-dehydrogenase isozyme 2target
Hydrocortisone butyrate3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
Hydrocortisone butyrateSolute carrier family 22 member 8transporter
Hydrocortisone cypionateAnnexin A1target
Hydrocortisone cypionateGlucocorticoid receptortarget
Hydrocortisone cypionateSex hormone-binding globulincarrier
Hydrocortisone cypionateCytochrome P450 3A4enzyme
Hydrocortisone cypionateCytochrome P450 3A5enzyme
Hydrocortisone cypionateCytochrome P450 3A7enzyme
Hydrocortisone cypionateP-glycoprotein 1transporter
Hydrocortisone cypionateSolute carrier organic anion transporter family member 1A2transporter
Hydrocortisone cypionateATP-binding cassette sub-family G member 2transporter
Hydrocortisone cypionateCytochrome P450 2C8enzyme
Hydrocortisone cypionateCorticosteroid-binding globulincarrier
Hydrocortisone cypionateCorticosteroid 11-beta-dehydrogenase isozyme 2target
Hydrocortisone cypionate3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
Hydrocortisone cypionateSolute carrier family 22 member 8transporter
Hydrocortisone phosphateAnnexin A1target
Hydrocortisone phosphateGlucocorticoid receptortarget
Hydrocortisone phosphateSex hormone-binding globulincarrier
Hydrocortisone phosphateCytochrome P450 3A4enzyme
Hydrocortisone phosphateCytochrome P450 3A5enzyme
Hydrocortisone phosphateCytochrome P450 3A7enzyme
Hydrocortisone phosphateP-glycoprotein 1transporter
Hydrocortisone phosphateSolute carrier organic anion transporter family member 1A2transporter
Hydrocortisone phosphateATP-binding cassette sub-family G member 2transporter
Hydrocortisone phosphateCytochrome P450 2C8enzyme
Hydrocortisone phosphateCorticosteroid-binding globulincarrier
Hydrocortisone phosphateCorticosteroid 11-beta-dehydrogenase isozyme 2target
Hydrocortisone phosphate3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
Hydrocortisone phosphateSolute carrier family 22 member 8transporter
Hydrocortisone probutateAnnexin A1target
Hydrocortisone probutateGlucocorticoid receptortarget
Hydrocortisone probutateSex hormone-binding globulincarrier
Hydrocortisone probutateCytochrome P450 3A4enzyme
Hydrocortisone probutateCytochrome P450 3A5enzyme
Hydrocortisone probutateCytochrome P450 3A7enzyme
Hydrocortisone probutateP-glycoprotein 1transporter
Hydrocortisone probutateSolute carrier organic anion transporter family member 1A2transporter
Hydrocortisone probutateATP-binding cassette sub-family G member 2transporter
Hydrocortisone probutateCytochrome P450 11B1, mitochondrialenzyme
Hydrocortisone probutateCytochrome P450 11B2, mitochondrialenzyme
Hydrocortisone probutateCytochrome P450 2C8enzyme
Hydrocortisone probutateCorticosteroid-binding globulincarrier
Hydrocortisone probutateCorticosteroid 11-beta-dehydrogenase isozyme 2target
Hydrocortisone probutate3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
Hydrocortisone probutateSolute carrier family 22 member 8transporter
Hydrocortisone valerateAnnexin A1target
Hydrocortisone valerateGlucocorticoid receptortarget
Hydrocortisone valerateSex hormone-binding globulincarrier
Hydrocortisone valerateCytochrome P450 3A4enzyme
Hydrocortisone valerateCytochrome P450 3A5enzyme
Hydrocortisone valerateCytochrome P450 3A7enzyme
Hydrocortisone valerateP-glycoprotein 1transporter
Hydrocortisone valerateSolute carrier organic anion transporter family member 1A2transporter
Hydrocortisone valerateATP-binding cassette sub-family G member 2transporter
Hydrocortisone valerateCytochrome P450 11B1, mitochondrialenzyme
Hydrocortisone valerateCytochrome P450 11B2, mitochondrialenzyme
Hydrocortisone valerateCytochrome P450 2C8enzyme
Hydrocortisone valerateCorticosteroid-binding globulincarrier
Hydrocortisone valerateCorticosteroid 11-beta-dehydrogenase isozyme 2target
Hydrocortisone valerate3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
Hydrocortisone valerateSolute carrier family 22 member 8transporter
Hydrocortisone succinateCytochrome P450 3A4enzyme
Hydrocortisone succinateCytochrome P450 2C8enzyme
Hydrocortisone succinateCytochrome P450 11B1, mitochondrialenzyme
Hydrocortisone succinateCytochrome P450 11B2, mitochondrialenzyme
HydroxyprogesteroneCytochrome P450 3A4enzyme