Name
Prodrugs
Accession Number
DBCAT000851
Description

Not Available

Drugs
DrugDrug Description
ValaciclovirAn guanine nucleoside antiviral used to treat herpes exacerbations.
CandoxatrilCandoxatril is the orally-active prodrug of candoxatrilat (UK-73967), a potent neutral endopeptidase (NEP) inhibitor.
TazaroteneAn acetylenic retinoid used to treat fine wrinkles, mottled pigmentation of the skin, acne vulgaris, and plaque psoriasis.
BalsalazideAn aminosalicylate used to treat ulcerative colitis.
FosphenytoinAn antiepileptic agent used for the management of generalized convulsive status epilepticus and prevention and treatment of seizures occurring during neurosurgery.
BambuterolA long acting beta2-adrenoceptor agonist for the management of lung diseases associated with bronchospasm.
CefpodoximeA third-generation cephalosporin antibiotic used in the treatment of various bacterial infections, including gonorrhea, community acquired pneumonia, and sinusitis.
TretazicarTretazicar is under investigation in clinical trial NCT00746590 (Study of Anti-tumour Effects and Safety of Prolarix™ in Hepatocellular Carcinoma).
IlepatrilInvestigated for use/treatment in hypertension.
PropacetamolPropacetamol is a paracetamol prodrug of intravenous administration used to control fever and pain of perioperative period in multimodal analgesia therapy.
SelexipagA non prostanoid IP prostacyclin receptor agonist used to treat pulmonary arterial hypertension.
FosinoprilatFosinoprilat is the active phosphinic acid metabolite of prodrug fosinopril, which is activated by esterases in vivo. It binds zinc with phosphinic acid group.
Prednisolone acetateA glucocorticoid used to treat a wide variety of endocrine, inflammatory, and immune conditions as well as for palliation of neoplastic conditions.
MolnupiravirAn orally bioavailable isopropylester cytidine analog used to treat COVID-19.
Melphalan flufenamideA melphalan prodrug used to treat relapsed or refractory multiple myeloma.
LonapegsomatropinA human growth hormone indicated in the treatment of growth failure due to inadequate endogenous growth hormone secretion.
RemdesivirA nucleoside analog used to treat RNA virus infections including COVID-19.
Drugs & Drug Targets
DrugTargetType
ValaciclovirThymidine kinasetarget
ValaciclovirDNA polymerase catalytic subunittarget
ValaciclovirSolute carrier family 15 member 1transporter
ValaciclovirSolute carrier family 15 member 2transporter
ValaciclovirSolute carrier family 22 member 8transporter
ValaciclovirSolute carrier family 22 member 6transporter
ValaciclovirSodium- and chloride-dependent neutral and basic amino acid transporter B(0+)transporter
ValaciclovirIleal sodium/bile acid cotransportertransporter
ValaciclovirGuanylate kinaseenzyme
ValaciclovirThymidine kinaseenzyme
CandoxatrilNeprilysintarget
CandoxatrilAngiotensin-converting enzymetarget
TazaroteneRetinoic acid receptor alphatarget
TazaroteneRetinoic acid receptor RXR-betatarget
TazaroteneRetinoic acid receptor gammatarget
TazaroteneRetinoic acid receptor betatarget
TazaroteneCytochrome P450 2C8enzyme
BalsalazideProstaglandin G/H synthase 1target
BalsalazideProstaglandin G/H synthase 2target
BalsalazideArachidonate 5-lipoxygenasetarget
BalsalazidePeroxisome proliferator-activated receptor gammatarget
BalsalazideNADPH azoreductaseenzyme
FosphenytoinSodium channel protein type 5 subunit alphatarget
FosphenytoinCytochrome P450 2C19enzyme
FosphenytoinCytochrome P450 2B6enzyme
FosphenytoinCytochrome P450 2C9enzyme
FosphenytoinCytochrome P450 3A4enzyme
FosphenytoinSerum albumincarrier
FosphenytoinCytochrome P450 1A2enzyme
FosphenytoinUDP-glucuronosyltransferase 1-6enzyme
FosphenytoinUDP-glucuronosyltransferase 1-9enzyme
FosphenytoinThyroxine-binding globulincarrier
BambuterolBeta-2 adrenergic receptortarget
BambuterolCholinesteraseenzyme
BambuterolCholinesterasetarget
CefpodoximePeptidoglycan synthase FtsItarget
TretazicarOxygen-insensitive NAD(P)H nitroreductasetarget
TretazicarRibosyldihydronicotinamide dehydrogenase [quinone]target
PropacetamolCholinesteraseenzyme
PropacetamolProstaglandin G/H synthase 1target
PropacetamolProstaglandin G/H synthase 2target
PropacetamolTransient receptor potential cation channel subfamily V member 1target
PropacetamolCannabinoid receptor 1target
PropacetamolCytochrome P450 2E1enzyme
PropacetamolCytochrome P450 1A2enzyme
PropacetamolCytochrome P450 2D6enzyme
PropacetamolUDP-glucuronosyltransferase 1-1enzyme
PropacetamolUDP-glucuronosyltransferase 1-6enzyme
PropacetamolUDP-glucuronosyltransferase 1-9enzyme
PropacetamolUDP-glucuronosyltransferase 2B15enzyme
PropacetamolUDP-glucuronosyltransferase 1-10enzyme
PropacetamolSulfotransferase 1A1enzyme
PropacetamolSulfotransferase 1A3/1A4enzyme
PropacetamolEstrogen sulfotransferaseenzyme
PropacetamolBile salt sulfotransferaseenzyme
PropacetamolArylamine N-acetyltransferase 2enzyme
PropacetamolCytochrome P450 2C9enzyme
PropacetamolCytochrome P450 3A4enzyme
SelexipagProstacyclin receptortarget
SelexipagLiver carboxylesterase 1enzyme
SelexipagCytochrome P450 2C8enzyme
SelexipagCytochrome P450 3A4enzyme
SelexipagSolute carrier organic anion transporter family member 1B1transporter
SelexipagSolute carrier organic anion transporter family member 1B3transporter
SelexipagP-glycoprotein 1transporter
Prednisolone acetateCorticosteroid-binding globulincarrier
Prednisolone acetateCytochrome P450 3A4enzyme
Prednisolone acetateGlucocorticoid receptortarget
Prednisolone acetateSolute carrier organic anion transporter family member 1A2transporter
Prednisolone acetateP-glycoprotein 1transporter
Prednisolone acetateSerum albumincarrier
Melphalan flufenamideAminopeptidase Nenzyme
Melphalan flufenamideDNAtarget
LonapegsomatropinCorticosteroid 11-beta-dehydrogenase isozyme 1enzyme
LonapegsomatropinGrowth hormone receptortarget
LonapegsomatropinProlactin receptortarget
LonapegsomatropinCytochrome P450 1A2enzyme
LonapegsomatropinCytochrome P450 2C19enzyme
LonapegsomatropinP-glycoprotein 1transporter
RemdesivirReplicase polyprotein 1abtarget
RemdesivirRNA-directed RNA polymerase Ltarget
RemdesivirCytochrome P450 2C8enzyme
RemdesivirCytochrome P450 2D6enzyme
RemdesivirCytochrome P450 3A4enzyme
RemdesivirSolute carrier organic anion transporter family member 1B1transporter
RemdesivirP-glycoprotein 1transporter
RemdesivirSolute carrier organic anion transporter family member 1B3transporter
RemdesivirBile salt export pumptransporter
RemdesivirMultidrug resistance-associated protein 4transporter
RemdesivirSodium/bile acid cotransportertransporter
RemdesivirLiver carboxylesterase 1enzyme
RemdesivirLysosomal protective proteinenzyme
RemdesivirReplicase polyprotein 1abtarget
RemdesivirReplicase polyprotein 1abtarget
RemdesivirMultidrug and toxin extrusion protein 1transporter