Quinazolines

Name
Quinazolines
Accession Number
DBCAT000883
Description
Not Available
Drugs
DrugDrug Description
PrazosinAn alpha-blocker that causes a decrease in total peripheral resistance and is used to treat hypertension.
MetolazoneA thiazide-like diuretic used to treat hypertension.
ErlotinibAn EGFR tyrosine kinase inhibitor used to treat certain small cell lung cancers or advanced metastatic pancreatic cancers.
DoxazosinAn alpha-1 adrenergic receptor used to treat mild to moderate hypertension and urinary obstruction due to benign prostatic hyperplasia.
TrimetrexateA folate antagonist used for the treatment of moderate-to-severe Pneumocystis carinii pneumonia (PCP) in immunocompromised patients as an alternative therapy in combination with leucovorin.
TerazosinAn alpha-1 adrenergic antagonist used in the treatment of symptomatic benign prostatic hyperplasia and management of hypertension.
MethaqualoneFor the treatment of insomnia, and as a sedative and muscle relaxant.
HalofuginoneFor the treatment of scleroderma, cancer, and restenosis.
TetrodotoxinFor the treatment of chronic and breakthrough pain in advanced cancer patients as well as for the treatment of opioid dependence.
ElinogrelInvestigated for use/treatment in cardiovascular disorders and myocardial infarction.
LinagliptinA dipeptidyl peptidase-4 (DPP-4) inhibitor used to manage hyperglycemia in patients with type 2 diabetes mellitus.
IdelalisibAn antineoplastic kinase inhibitor used to treat chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL).
SP-8203SP-8203 has been used in trials studying the treatment of Ischemic Stroke.
MK-0249MK0249 has been used in trials studying the treatment of Hypopnea Syndrome, Alzheimer's Disease, Paranoid Schizophrenia, Sleep Apnea, Obstructive, and Excessive Daytime Sleepiness, among others.
DacomitinibA medication used to treat non small cell lung cancer with EGFR exon 19 deletion of exon 21 L858R substitution.
SelurampanelSelurampanel has been investigated in Adrenocortical Adenoma and Sarcoma, Endometrial Stromal.
KetanserinKetanserin has been investigated for the treatment of Septic Shock, Severe Sepsis, and Diabetic Foot Ulcer.
ATX-914Axt914 is under investigation in clinical trial NCT00417261 (Safety, Tolerability, Pharmacodynamic and Pharmacokinetic Effects of Single and Multiple-Doses of ATF936 and AXT914 Administered Orally in Healthy Subjects.).
AvadomideAvadomide is under investigation in clinical trial NCT02031419 (Novel Combinations of CC-122, CC-223, CC-292, and Rituximab in Diffuse Large B-cell Lymphoma and Follicular Lymphoma).
GefitinibA tyrosine kinase inhibitor used as first-line therapy to treat non-small cell lung carcinoma (NSCLC) that meets certain genetic mutation criteria.
LapatinibAn antineoplastic agent and tyrosine kinase inhibitor used for the treatment of advanced or metastatic HER-negative breast cancer in patients who received prior chemotherapeutic treatments.
AfatinibAn antineoplastic agent used for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) with non-resistant EGFR mutations or resistance to platinum-based chemotherapy.
ApabetaloneApabetalone has been investigated for the treatment of Diabetes, Atherosclerosis, and Coronary Artery Disease.
Drugs & Drug Targets
DrugTargetType
PrazosinAlpha-1A adrenergic receptortarget
PrazosinAlpha-1B adrenergic receptortarget
PrazosinAlpha-1D adrenergic receptortarget
PrazosinPotassium voltage-gated channel subfamily H member 2target
PrazosinAlpha-1-acid glycoprotein 1carrier
PrazosinSolute carrier family 22 member 1transporter
PrazosinSolute carrier family 22 member 3transporter
PrazosinP-glycoprotein 1transporter
PrazosinATP-binding cassette sub-family G member 2transporter
PrazosinAlpha-2A adrenergic receptortarget
PrazosinAlpha-2B adrenergic receptortarget
PrazosinAlpha-1 adrenergic receptorstarget
MetolazoneSolute carrier family 12 member 3target
ErlotinibEpidermal growth factor receptortarget
ErlotinibCytochrome P450 3A4enzyme
ErlotinibATP-binding cassette sub-family G member 2transporter
ErlotinibP-glycoprotein 1transporter
ErlotinibNuclear receptor subfamily 1 group I member 2target
ErlotinibCytochrome P450 3A5enzyme
ErlotinibCytochrome P450 1A1enzyme
ErlotinibCytochrome P450 1A2enzyme
ErlotinibCytochrome P450 1B1enzyme
ErlotinibCytochrome P450 2D6enzyme
ErlotinibCytochrome P450 2C8enzyme
ErlotinibUDP-glucuronosyltransferase 1-1enzyme
ErlotinibSerum albumincarrier
ErlotinibAlpha-1-acid glycoprotein 1carrier
ErlotinibSolute carrier organic anion transporter family member 2B1transporter
DoxazosinAlpha-1A adrenergic receptortarget
DoxazosinAlpha-1D adrenergic receptortarget
DoxazosinHERG human cardiac K+ channeltarget
DoxazosinP-glycoprotein 1transporter
DoxazosinCytochrome P450 2C19enzyme
DoxazosinCytochrome P450 2D6enzyme
DoxazosinSolute carrier family 22 member 1transporter
DoxazosinCytochrome P450 3A4enzyme
DoxazosinAlpha-1B adrenergic receptortarget
DoxazosinCytochrome P450 2C9enzyme
TrimetrexateDihydrofolate reductasetarget
TrimetrexateDihydrofolate reductaseenzyme
TrimetrexateFolate transporter 1transporter
TerazosinAlpha-1A adrenergic receptortarget
TerazosinAlpha-1B adrenergic receptortarget
TerazosinAlpha-1D adrenergic receptortarget
TerazosinPotassium voltage-gated channel subfamily H member 2target
TerazosinPotassium voltage-gated channel subfamily H member 6target
TerazosinPotassium voltage-gated channel subfamily H member 7target
TerazosinP-glycoprotein 1transporter
TerazosinTransforming growth factor beta-1target
MethaqualoneCytochrome P450 3A4enzyme
HalofuginoneCollagen alpha-1(I) chaintarget
Halofuginone72 kDa type IV collagenasetarget
TetrodotoxinSodium channel protein type 1 subunit alphatarget
TetrodotoxinSodium channel protein type 2 subunit alphatarget
TetrodotoxinSodium channel protein type 3 subunit alphatarget
TetrodotoxinSodium channel protein type 8 subunit alphatarget
ElinogrelP2Y purinoceptor 12target
LinagliptinDipeptidyl peptidase 4target
LinagliptinCytochrome P450 3A4enzyme
LinagliptinP-glycoprotein 1transporter
LinagliptinSolute carrier family 22 member 1transporter
LinagliptinSolute carrier family 22 member 2transporter
LinagliptinSolute carrier family 22 member 3transporter
IdelalisibPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget
IdelalisibATP-binding cassette sub-family G member 2transporter
IdelalisibP-glycoprotein 1transporter
IdelalisibAldehyde oxidaseenzyme
IdelalisibCytochrome P450 2C8enzyme
IdelalisibCytochrome P450 2C19enzyme
IdelalisibCytochrome P450 2B6enzyme
IdelalisibCytochrome P450 3A4enzyme
IdelalisibSolute carrier organic anion transporter family member 1B1transporter
IdelalisibSolute carrier organic anion transporter family member 1B3transporter
IdelalisibCytochrome P450 3A5enzyme
IdelalisibCytochrome P450 3A43enzyme
IdelalisibCytochrome P450 3A7enzyme
IdelalisibUDP-glucuronosyltransferase 1-4enzyme
DacomitinibCytochrome P450 2D6enzyme
DacomitinibSerum albumincarrier
DacomitinibCytochrome P450 3A4enzyme
DacomitinibCytochrome P450 2C9enzyme
DacomitinibUDP-glucuronosyltransferase 1-1enzyme
DacomitinibP-glycoprotein 1transporter
DacomitinibATP-binding cassette sub-family G member 2transporter
DacomitinibSolute carrier family 22 member 1transporter
DacomitinibEpidermal growth factor receptortarget
Ketanserin5-hydroxytryptamine receptor 2Atarget
GefitinibEpidermal growth factor receptortarget
GefitinibCytochrome P450 3A4enzyme
GefitinibCytochrome P450 2D6enzyme
GefitinibP-glycoprotein 1transporter
GefitinibATP-binding cassette sub-family G member 2transporter
GefitinibCytochrome P450 3A5enzyme
GefitinibCytochrome P450 1A1enzyme
GefitinibCytochrome P450 2C9enzyme
GefitinibCytochrome P450 2C19enzyme
GefitinibSerum albumincarrier
GefitinibAlpha-1-acid glycoprotein 1carrier
LapatinibEpidermal growth factor receptortarget
LapatinibReceptor tyrosine-protein kinase erbB-2target
LapatinibCytochrome P450 3A4enzyme
LapatinibCytochrome P450 2C8enzyme
LapatinibP-glycoprotein 1transporter
LapatinibAntigen peptide transporter 1transporter
LapatinibCytochrome P450 3A5enzyme
LapatinibCytochrome P450 2C19enzyme
AfatinibEpidermal growth factor receptortarget
AfatinibReceptor tyrosine-protein kinase erbB-2target
AfatinibReceptor tyrosine-protein kinase erbB-4target
AfatinibP-glycoprotein 1transporter
AfatinibATP-binding cassette sub-family G member 2transporter