Adrenergic alpha-Antagonists
- Name
- Adrenergic alpha-Antagonists
- Accession Number
- DBCAT000696 (DBCAT002329)
- Description
Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
- ATC Classification
- Drugs
Drug Drug Description 1-benzylimidazole 1-benzylimidazole, an N-imidazole derivative, has been shown to have strong cardiotonic activity. Acepromazine Acepromazine was first used in humans in the 1950s as an antipsychotic agent. It is now rarely used in humans. Acepromazine is frequently used in animals as a sedative and... Alfuzosin An alpha-1 adrenergic antagonist used in the symptomatic management of benign prostatic hypertrophy (BPH). Amitriptyline A tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety. Amoxapine A tricyclic antidepressant used in the treatment of neurotic or reactive depressive disorders and endogenous or psychotic depression. Aripiprazole An atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome. Aripiprazole lauroxil An antipsychotic used to treat schizophrenia in adults. Asenapine An atypical antipsychotic used to treat patients with bipolar I disorder and patients with schizophrenia. Atipamezole For the reversal of the sedative and analgesic effects of dexmedetomidine and medetomidine in dogs. Bevantolol For the treatment of angina pectoris and hypertension. Brexpiprazole A serotonin–dopamine activity modulator used in the treatment of major depressive disorder as an adjunct, schizophrenia, and agitation associated with dementia due to Alzheimer’s disease. Bromocriptine A dopamine D2 receptor agonist used for the treatment of galactorrhea due to hyperprolactinemia and other prolactin-related conditions, as well as in early Parkinsonian Syndrome. Bucindolol Bucindolol has been investigated in Heart Failure. Buflomedil Not Annotated Bunazosin Bunazosin has been used in trials studying the treatment of High Blood Pressure. Carvedilol A non selective beta-adrenergic antagonist used to treat mild to severe chronic heart failure, hypertension, and left ventricular dysfunction following myocardial infarction in clinically stable patients. Chlorpromazine A phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children. Clozapine An atypical or second-generation antipsychotic drug used in treatment-resistant schizophrenia and to decrease suicide risk in schizophrenic patients. Dapiprazole Used in the treatment of iatrogenically induced mydriasis produced by adrenergic (phenylephrine) or parasympatholytic (tropicamide) agents used in certain eye examinations. Dihydroergotamine An ergot alkaloid used in the acute treatment of migraine headache and cluster headache. Dihydroergotoxine Not Annotated Doxazosin An alpha-1 adrenergic receptor used to treat mild to moderate hypertension and urinary obstruction due to benign prostatic hyperplasia. Doxepin A psychotropic agent used for the treatment of depression, anxiety, manic-depressive disorder, and insomnia. Dronedarone An antiarrhythmic agent used in the reduce the risk of hospitalization in patients with paroxysmal or persistent atrial fibrillation. Droperidol A butyrophenone derivative and dopamine antagonist used to prevent and treat postoperative nausea and vomiting. Dutasteride An antiandrogenic compound that is used for the treatment of symptomatic benign prostatic hyperplasia (BPH) in adult males by inhibiting 5-alpha reductase. Ergoloid mesylate A nootropic with an unknown mechanism of action indicated in individuals over sixty who manifest signs and symptoms of an idiopathic decline in mental capacity. Ergotamine An alpha-1 selective adrenergic agonist vasoconstrictor used to treat migraines with or without aura and cluster headaches. Esmirtazapine Investigated for use/treatment in insomnia and sleep disorders. Finasteride An antiandrogenic compound that is used for the treatment of symptomatic benign prostatic hyperplasia (BPH) and male pattern hair loss in adult males by inhibiting Type II 5-alpha reductase. Flupentixol A thioxanthene neuroleptic used to treat schizophrenia and depression. Idazoxan Idazoxan has been used in trials studying the basic science of Molecular Imaging, Alzheimer Disease, and Major Depressive Disorder. Ifenprodil N-methyl-D-aspartate (NMDA) receptors (NMDARs) are members of the ionotropic glutamate receptor family, with key roles in brain development and neurological function. NMDARs are heterotetramers that typically involve a dimer of... Iloperidone An atypical antipsychotic agent used to treat schizophrenia and manic or mixed episodes associated with bipolar I disorder in adults. Imipramine A tricyclic antidepressant indicated for the treatment of depression and to reduce childhood enuresis. Indoramin Indoramin is a discontinued piperidine antiadrenergic drug with the trade names Baratol and Doralese. It is a selective alpha-1 adrenergic antagonist with no reflex tachycardia and direct myocardial depression action. Labetalol An alpha and beta adrenergic antagonist used to treat hypertension, angina, and sympathetic overactivity syndrome. Lurasidone An atypical antipsychotic used to treat schizophrenia and depressive episodes associated with bipolar I disorder. Methotrimeprazine A phenothiazine used in the management of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder. Mirtazapine A tetracyclic antidepressant used in the treatment of major depression and is used off-label as a drug for insomnia and to increase appetite. Moxisylyte According to the WHO, moxisylyte is indicated for the symptomatic management of sequelae of cerebral infarction or hemorrhage. The cerebral infarction is characterized by the blockage of the artery either... Naftopidil Naftopidil has been investigated for the treatment of Disorder of Urinary Stent. Nefazodone An antidepressant used in the treatment of depression. Nicardipine A calcium channel blocker used for the short-term treatment of hypertension and chronic stable angina. Nicergoline An ergot derivative use for the treatment of symptoms associated with cerebrovascular abnormalities. Niguldipine Niguldipine is a calcium channel blocker drug (CCB) with a1-adrenergic antagonist properties. Nortriptyline A tricyclic antidepressant used in the treatment of depression. Olanzapine An antipsychotic drug used in the management of schizophrenia, bipolar 1 disorder, and agitation associated with these disorders. ORM-12741 ORM-12741 has been used in trials studying the basic science and treatment of Alzheimer's Disease. Paliperidone An atypical antipsychotic used in the treatment of schizophrenia and other schizoaffective or delusional disorders. Periciazine A phenothiazine used with other medications to treat aggressiveness, impulsiveness, and hostility associated with psychiatric conditions such as schizophrenia. Phenoxybenzamine An alpha adrenergic antagonist used to treat pheochromocytoma and episodes of hypertension and sweating. Phentolamine An alpha-adrenergic blocker used to treat hypertensive episodes, diagnose pheochromocytoma, treat norepinephrine administration site reactions, and reverse soft tissue anesthesia and mydriasis. Pizotifen A serotonin and tryptamine antagonist indicated for migraine prophylaxis. Prazosin An alpha-blocker that causes a decrease in total peripheral resistance and is used to treat hypertension. Promazine A phenothiazine used to manage schizophrenia. Propiomazine Propiomazine is largely used for its antihistamininc sleep inducing effects in treating insomnia. Propiverine An antimuscarinic agent used to treat urinary incontinence or increased urinary frequency or urgency. Quetiapine An atypical antipsychotic agent used for the management of bipolar disorder, schizophrenia, and major depressive disorder. Quinidine A medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias. Risperidone A second-generation antipsychotic medication used to treat a number of mental health disorders including schizophrenia, bipolar mania, psychosis, or as an adjunct in severe depression. Silodosin An alpha-1 adrenergic receptor antagonist used to treat symptoms associated with benign prostatic hyperplasia (BPH). Sunepitron Sunepitron is a small molecule drug. Sunepitron has a monoisotopic molecular weight of 329.19 Da. Tamsulosin An alpha-1A and alpha-1B adrenergic receptor antagonist used to treat benign prostatic hyperplasia, ureteral stones, prostatitis, and female voiding dysfunction. Terazosin An alpha-1 adrenergic antagonist used in the treatment of symptomatic benign prostatic hyperplasia and management of hypertension. Thioproperazine An antipsychotic indicated for the management of acute and chronic schizophrenia, including cases that are refractory to more common neuroleptics. May also be used to treat manic syndromes. Thioridazine A phenothiazine antipsychotic used to treat schizophrenia and generalized anxiety disorder. Tolazoline A vasodilator used to treat pulmonary artery anomalies. Trazodone A serotonin uptake inhibitor used to treat major depressive disorder. Trifluoperazine A phenothiazine used to treat depression, anxiety, and agitation. Trimazosin Trimazosin is a sympatholytic alpha blocker. Trimipramine A tricyclic antidepressant used to treat depression. Urapidil A combination adrenergic antagonist and serotonin agonist given orally for the treatment of essential hypertension and intravenously in hypertensive emergencies. Verapamil A non-dihydropyridine calcium channel blocker used in the treatment of angina, arrhythmia, and hypertension. Viloxazine A selective norepinephrine reuptake inhibitor indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) in adults in children. Yohimbine An alpha-2-adrenergic blocker and sympatholytic found in supplements used to. Ziprasidone An atypical antipsychotic used to manage schizophrenia, bipolar mania, and agitation in patients with schizophrenia. Zuclopenthixol An antipsychotic indicated for the management of schizophrenia. The acuphase formulation is indicated for initial treatment of acute psychosis or exacerbation of psychosis, while the depot formulation is best for maintenance.