Tinea Pedis (DBCOND0000153)

Identifiers

Synonyms

Athlete Foot / Athletes Foot / Foot Infection Tinea Pedis / Athlete's Foot / Tinea pedis / Mycosis pedis / Foot tinea / Ringworm of foot / Dermatophytosis of foot / Tinea pedis (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Amorolfine	A morpholine derivative commonly applied as a lacquer for onychomycosis but is also used for superficial dermatomycosis.	No drug targets
Benzoic acid	An antimicrobial food additive.	Cocaine esterasetarget D-amino-acid oxidasetarget Chlorocatechol 1,2-dioxygenasetarget 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolasetarget Non-heme chloroperoxidasetarget Oxygen-insensitive NAD(P)H nitroreductasetarget Hydroxyquinol 1,2-dioxygenasetarget Replication proteintarget Solute carrier organic anion transporter family member 2B1transporter Organic anion transporter 3transporter Monocarboxylate transporter 1transporter Solute carrier family 15 member 1target Ras-related protein Rab-9Atarget
Butenafine	A topical antifungal used to treat tinea versicolor, tinea pedis, tinea cruris, and tinea corporis.	Squalene monooxygenasetarget Squalene monooxygenasetarget
Ciclopirox	A broad-spectrum topical antifungal agent used to treat mild to moderate onychomycosis of fingernails and toenails in immunocompetent patients.	Sodium/potassium-transporting ATPase subunit alpha-1target
Clioquinol	An antifungal cream used to treat a variety of fungal infections.	Kappa-type opioid receptortarget
Clotrimazole	A topical broad-spectrum antifungal agent used for the treatment of a wide variety of dermatophyte infections and candidiasis.	Intermediate conductance calcium-activated potassium channel protein 4target Cytochrome P450 2D6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 3A4enzyme Cytochrome P450 2B6enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 2A6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A7enzyme Lanosterol 14-alpha demethylasetarget Nuclear receptor subfamily 1 group I member 2target Hydroxycarboxylic acid receptor 2target Bile salt export pumptransporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter Ergosteroltarget C-X-C chemokine receptor type 2target
Econazole	A topical antifungal used to treat tinea pedis, tinea cruris, tinea corporis, cutaneous candidiasis and tinea versicolor.	Aromataseenzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A4enzyme Lanosterol 14-alpha demethylasetarget Nuclear receptor subfamily 1 group I member 2target
Fenticonazole	An imidazole antifungal used to treat a variety of topical fungal infections.	No drug targets
Flutrimazole	A topical antifungal used to treat pityriasis capitis and seborrheic dermatitis.	No drug targets
Griseofulvin	An antifungal agent used to treat a variety of superficial tinea infections and fungal infections of the fingernails and toes.	Keratin, type I cytoskeletal 12target Cytochrome P450 1A2enzyme Cytochrome P450 3A4enzyme Tubulin beta chaintarget
Miconazole	An azole antifungal with broad-spectrum activity used to treat fungal infections affecting the vagina, mouth and skin, including candidiasis.	Cytochrome P450 2C9enzyme Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Lanosterol 14-alpha demethylasetarget Nitric oxide synthase 3target Nitric oxide synthase, inducibletarget Cytochrome P450 11B1, mitochondrialenzyme Cytochrome P450 2A6enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2E1enzyme Nuclear receptor subfamily 1 group I member 2target Lanosterol 14-alpha demethylaseenzyme Aromataseenzyme Calcium-activated potassium channeltarget Voltage-gated Potassium Channelstarget Inward rectifier potassium channeltarget Voltage gated L-type calcium channeltarget Albumincarrier Cytochrome P450 2C8enzyme
Naftifine	An antifungal agent used to treat infections of the Tinea, Trichophyton, and Epidermophyton species.	Squalene monooxygenasetarget
Oxiconazole	A topical antifungal used to treat a variety of dermatophyte infections.	Lanosterol 14-alpha demethylasetarget Lanosterol synthasetarget Cytochrome P450 3A4enzyme Cytochrome P450 2C19enzyme Nuclear receptor subfamily 1 group I member 2target
Sulconazole	A topical antifungal agent used for the treatment of tinea cruris, tinea corporis, and tinea versicolor caused by susceptible fungal strains.	Cytochrome P450 1A2enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2D6enzyme Lanosterol 14-alpha demethylasetarget
Terbinafine	An allylamine antifungal used to treat dermatophyte infections of toenails and fingernails as well as other fungal skin infections.	Squalene monooxygenasetarget Cytochrome P450 2D6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 1A2enzyme Cytochrome P450 3A4enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C19enzyme Prostaglandin G/H synthase 1enzyme Albumincarrier alpha1-acid glycoproteincarrier ABC multidrug transporter MDR2transporter Squalene monooxygenasetarget
Tolnaftate	An antifungal agent used to treat various skin infections caused by fungi.	Squalene monooxygenasetarget Squalene monooxygenasetarget
Undecylenic acid	An antifungal used to treat tinea species infections.	Calpain-1 catalytic subunittarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT06296537	Effectiveness of Balance Training And Dynamic Neuromuscular Stabilization Training in Amateur Athletes With Chronic Ankle Instability	No drug interventions	treatment	Not Available	recruiting
NCT05754463	The Effect Of Plyometric Training On Balance And Proprioception In Different Branches Athletes	No drug interventions	prevention	Not Available	completed
NCT04289857	Neurodynamics to Improve Jump Functionality in Trampoline Jump Gymnasts	No drug interventions	prevention	Not Available	withdrawn
NCT05746663	A Morphological Study in Volleyball Athletes With Cronic Ankle Instability	No drug interventions	Not Available	Not Available	recruiting
NCT04568577	Effects of the Elastic Taping on the Chronic Ankle Instability	No drug interventions	treatment	Not Available	completed
NCT04439981	Curcuma Extract Beneficial for Muscle Damage	No drug interventions	treatment	Not Available	completed
NCT02882438	Glucosamine Sulphate and Ginkgo Biloba as Antifungal Activity for Treating Tinea Pedis	No drug interventions	treatment	1	unknown_status
NCT00768599	A Study of Econazole Foam 1% in Athlete's Foot	No drug interventions	treatment	2	completed
NCT00856596	Once a Day Topical Treatment for Athlete's Foot Fungus Inbetween the Toes in Males and Females	No drug interventions	treatment	3	unknown_status
NCT00750139	Multicenter Study of the Safety and Efficacy of NAFT-500 in Tinea Pedis	No drug interventions	treatment	3	completed
NCT01353976	Safety and Efficacy of Econazole Nitrate Foam 1% in Subjects With Tinea Pedis	No drug interventions	treatment	3	completed
NCT01358240	Safety and Efficacy of Econazole Nitrate Foam 1% and Foam Vehicle in Subjects With Tinea Pedis	No drug interventions	treatment	3	completed
NCT00781664	Cumulative Irritation Test	No drug interventions	other	1	completed
NCT02842021	Efficacy and Safety of Product S2G6T-1in Patients With Symptomatic Inflammatory Interdigital Tinea Pedis	No drug interventions	treatment	2	terminated
NCT03129321	Therapeutic Equivalence and Safety of Two Econazole Nitrate Cream, 1% Products in Tinea Pedis	No drug interventions	treatment	3	completed
NCT01349998	Safety of a Topical Antifungal Treatment for Tinea Cruris, Tinea Pedis and Tinea Corporis	No drug interventions	Not Available	3	completed
NCT01891305	A Study to Evaluate the Efficacy and Safety of Oral VT-1161 in Patients With Moderate - Severe Interdigital Tinea Pedis	Oteseconazole	treatment	2	completed
NCT02871011	Nitric Oxide Releasing Solution (NORS) Footbath to Treat Athlete's Foot	Nitric Oxide Water	treatment	2	completed
NCT00233493	Spread of Dermatophytes Among Families	No drug interventions	Not Available	Not Available	unknown_status
NCT01580878	Evaluate the Safety & Bioequivalence of a Generic Butenafine Cream & Lotrimin Ultra® & Compare Both to a Vehicle Control in Treatment of Interdigital Tinea Pedis	No drug interventions	treatment	1	completed
NCT01433107	Efficacy and Safety of Terbinafine Film Forming Solution in Patients With Tinea Pedis	No drug interventions	treatment	3	completed
NCT00509275	A Study to Evaluate Efficacy and Safety of Three W0027 Regimens in the Treatment of Moccasin Type Tinea Pedis (MTTP)	No drug interventions	treatment	1	completed
NCT01105013	Evaluate the Efficacy and Safety of Tolnaftate Cream in the Treatment of Patients With Fungal Infections	No drug interventions	treatment	3	unknown_status
NCT01290341	Evaluation of the Efficacy and Safety of NAFT-600 in Subjects With Tinea Pedis	No drug interventions	treatment	3	completed
NCT03320486	Non-inferiority Trial of Dapaconazole Versus Ketoconazole	Dapaconazole Ketoconazole	treatment	3	completed
NCT01110330	An Efficacy Study of a New Formulation of Ketoconazole 2% Cream in Patients With Tinea Pedis, Commonly Known as Athlete's Foot	No drug interventions	treatment	3	terminated
NCT03897257	A Comparison Study of UHE-103 Cream in Subjects With Moccasin Type Tinea Pedis	No drug interventions	treatment	2	completed
NCT04152226	Open Label, Single-dose, Dose Escalating Evaluation of the Safety and Tolerability of DBI-001 in Patients With T. Pedis	No drug interventions	treatment	2	completed
NCT00848666	Safety and Efficacy of a Novel Topical Therapy for Tinea Pedis (Athlete's Foot)	No drug interventions	treatment	Not Available	unknown_status
NCT02132260	Evaluate the Safety and Efficacy of Naftifine Hydrochloride Cream 2% and Naftin® Cream 2% in Patients With Tinea Pedis	Naftifine	treatment	1	completed
NCT01580891	Evaluate the Clinical Equivalence of Two Naftifine HCl 1% Creams in Patients With Interdigital Tinea Pedis	No drug interventions	treatment	1	completed
NCT01096472	Efficacy and Safety of LAS41003 in the Treatment of Inflammatory Tinea Pedis	No drug interventions	treatment	2	completed
NCT00835510	Clinical Equivalence of Two Butenafine Hydrochloride 1% Creams in Patients With Interdigital Tinea Pedis	No drug interventions	treatment	1	completed
NCT04265521	Study With BioCool Footcare in Subjects With Tinea Pedis Interdigitalis and Heel Cracks, Calluses and/or Dry Feet	No drug interventions	treatment	Not Available	completed
NCT02606383	Non-inferiority Phase III Trial Comparing Dapaconazole Cream 2% With Ketoconazole Cream 2% in Patients With Tinea Pedis	No drug interventions	treatment	3	withdrawn
NCT01396811	Topical Antifungal Treatment for Tinea Pedis	No drug interventions	treatment	3	completed
NCT00804193	Safety and Equivalence of a Generic Ciclopirox Olamine Topical Suspension Compared to the Reference Ciclopirox Topical Suspension 0.77% for the Treatment of Tinea Pedis	No drug interventions	treatment	Not Available	completed
NCT04883593	A Study Comparing the Efficacy of TA103 and the Placebo Control in the Treatment of Interdigital Tinea Pedis.	No drug interventions	treatment	0	completed
NCT02767271	Maximal Use of Luliconazole Cream 1% in Pediatric Participants With Moderate to Severe Tinea Pedis or Tinea Cruris	No drug interventions	treatment	4	completed
NCT05493488	A Trial to Evaluate the Safety and Efficacy of DBI-001 Gel, DBI-002 Gel, and Aqueous Gel in Subjects With Tinea Pedis	No drug interventions	treatment	2	unknown_status
NCT01013909	Comparative Safety and Efficacy Study of New Bifonazol Spray vs Terbinafine Solution vs Placebo	No drug interventions	treatment	2	completed
NCT01396785	Topical Antifungal Treatment for Tinea Pedis	No drug interventions	treatment	3	completed
NCT01289015	Efficacy and Safety of NAFT-600 in Subjects With Tinea Pedis	No drug interventions	treatment	3	completed
NCT03999437	SINGLE-APPLICATION TERBINAFINE HYDROCHLORIDE (1%) TOPICAL LIQUID SOLUTION VERSUS A SINGLE-APPLICATION BUTENAFINE HYDROCHLORIDE (1%) TOPICAL LIQUID SOLUTION FOR THE TREATMENT OF TINEA PEDIS	No drug interventions	treatment	2	unknown_status
NCT01524432	Hygienic Socks With Antifungal Agent-loaded Microcapsules for Patients With Tinea Pedis	No drug interventions	treatment	1	completed
NCT02860052	SB208 for the Treatment of Tinea Pedis	No drug interventions	treatment	2	completed
NCT01519752	A Therapeutic Equivalence Study of Two Oxiconazole Nitrate Topical Cream Treatments for Patients With Tinea Pedis	No drug interventions	treatment	1	completed
NCT04203342	A Therapeutic Equivalence Study of Ketoconazole Cream 2%	No drug interventions	treatment	3	completed
NCT05363449	Safety, Tolerability, and Pharmacokinetics of UHE-103 Cream in Subjects With Tinea Cruris and/or Tinea Pedis	No drug interventions	treatment	1	completed
NCT00869336	Multicenter Study of the Efficacy and Safety of Luliconazole Cream in Tinea Pedis (Athlete's Foot)	No drug interventions	treatment	2	completed
NCT02633813	BE Study of Naftifine HCL	No drug interventions	treatment	3	completed
NCT03676686	Study With Nåva Foot Cream in Patients With Tinea Pedis Interdigitalis	No drug interventions	treatment	Not Available	completed
NCT02824926	Clinical Trial Comparing BL123 Versus Ketoconazole in Patients With Tinea Pedis	No drug interventions	treatment	2	completed
NCT01712360	Pharmacokinetic Study of Pediatric Subjects With Tinea Cruris and Tinea Pedis	No drug interventions	treatment	4	completed
NCT00893880	A Dose Response Trial to Evaluate Clinical and Mycological Effect of Nitric Oxide in Subjects With Tinea Pedis	No drug interventions	treatment	2	completed
NCT02394340	Study Evaluating the Drug Interaction Potential of Luliconazole Cream 1% in Participants With Tinea Pedis and Tinea Cruris	No drug interventions	treatment	4	completed
NCT00802672	Safety and Equivalence of a Generic Ciclopirox Olamine Cream Compared to the Reference Ciclopirox Cream 0.77% for the Treatment of Tinea Pedis	No drug interventions	treatment	3	completed
NCT03135912	Three-Arm Trial of Novel Treatment for Tinea Pedis	No drug interventions	treatment	2	completed
NCT03824912	Clinical Study to Evaluate the Therapeutic Equivalence of Ketoconazole Cream 2% in the Treatment of Tinea Pedis	No drug interventions	treatment	3	completed
NCT02335255	Evaluate Safety and Efficacy of Naftifine Hydrochloride Gel 2% and Naftin® Gel 2% in Tinea Pedis	No drug interventions	treatment	1	completed