Exocrine Pancreatic Insufficiency (DBCOND0000839)

Identifiers

Synonyms
Exocrine Pancreatic Insufficiency (EPI) / Exocrine pancreatic insufficiency / Pancreatic exocrine insufficiency / Exocrine pancreatic insufficiency (disorder) / Pancreatic failure / Pancreatic insufficiency (disorder) / Pancreatic insufficiency / Insufficiency pancreatic

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Pancrelipase
A purified form of porcine pancreatic lipase, amylase, and protease enzymes used to treat malabsorption associated with pancreatic insufficiency resulting from cystic fibrosis and pancreatitis.
Pancrelipase amylase
A lipase used to treat pancreatic exocrine insufficiency.
Pancrelipase lipase
A lipase used to treat pancreatic exocrine insufficiency.
Pancrelipase protease
A lipase used to treat pancreatic exocrine insufficiency.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT04375878
OPTION 2: A Trial to Assess the Safety and Efficacy of MS1819 in Enteric Capsules in Patients With Cystic FibrosisNo drug interventionstreatment2completed
NCT03746483
OPTION: A Trial to Assess the Safety & Efficacy of MS1819 in Patients With Exocrine Pancreatic Insufficiency Due to Cystic FibrosisNo drug interventionstreatment2completed
NCT04315311
Study Of Effects Of Oral CREON Capsules In Adult Participants With Exocrine Pancreatic Insufficiency Not Due To Cystic Fibrosis, Chronic Pancreatitis, Pancreatectomy, Or Pancreatic Cancertreatment4withdrawn
NCT03859869
A Study of Creon (Pancrelipase) in Resected and Non-resected Pancreatic Cancer Participants With Exocrine Pancreatic Insufficiency (EPI)treatment4terminated
NCT05082051
Oral CDX-7108 in Healthy Adults and EPI SubjectsNo drug interventionstreatment1completed
NCT05719311
Study to Assess an Enteric Microgranule Formulation of Adrulipase in Patients With Cystic FibrosisNo drug interventionstreatment2completed
NCT00500084
Phase III ALTU-135 CP Safety Trialtreatment3terminated
NCT06581653
Medication Adherence to Phone-supervised Pancreatic Enzyme Replacement TherapyNo drug interventionshealth_services_researchNot Availablerecruiting
NCT04966897
Assessment of a PERT-free Nutritional Therapeutic Delivery System for Cystic FibrosisNo drug interventionstreatmentNot Availablecompleted
NCT00775528
Study Investigating a Delayed-Release Pancrelipase in Patients With Pancreatic Exocrine Insufficiency Due to Cystic Fibrosistreatment3completed
NCT00788593
A Randomized, Double-Blind, Dose Response-Control, Crossover Study to Evaluate the Safety and Efficacy of Two Doses of EUR-1008 (APT-1008) in Chronic Pancreatitis (CP) Participants With Exocrine Pancreatic Insufficiency (EPI)treatment3completed
NCT00449878
Liprotamase Efficacy Trial in Patients With Cystic Fibrosis-Related Exocrine Pancreatic Insufficiencytreatment3completed
NCT04548778
BÜHLMANN fPELA in the Diagnosis of Exocrine Pancreatic InsufficiencyNo drug interventionsNot AvailableNot Availablerecruiting
NCT05804409
Screening for Pancreatic Exocrine Insufficieny in Metabolic Associated Fatty Liver Disease PatientsNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT05132309
Intestinal Microbiota Composition in Patients With Chronic Pancreatitis and Pancreatic Exocrine InsufficiencyNo drug interventionsNot AvailableNot Availablecompleted
NCT00559052
An Open-Label Study to Evaluate the Intraduodenal Delivery of Enzymes From Administration of VIOKASE16 in Exocrine Pancreatic Insufficiency (EPI)No drug interventionsdiagnostic2completed
NCT02175459
Investigating Predictive Factors of Diabetes Occurence After DuodenalpancreatectomyNo drug interventionsNot AvailableNot Availablerecruiting
NCT00662675
A Study of the Efficacy and Tolerability of Pancrelipase Microtablet (MT) Capsules for the Treatment of Cystic Fibrosis-dependent Exocrine Pancreatic Insufficiencytreatment3completed
NCT05480241
Exocrine Pancreatic Insufficiency After Acute Pancreatitis and Pancreatic Enzyme Replacement TherapyNo drug interventionstreatmentNot Availablerecruiting
NCT00408317
Safety and Efficacy Study of ULTRASE® MT20 in Participants With Cystic Fibrosis (CF) and Exocrine Pancreatic Insufficiency (PI)treatment3completed
NCT01430234
Enzyme Suppletion in Exocrine Pancreatic Dysfunctiontreatment4completed
NCT03407534
Detection of Exocrine Pancreatic Insufficiency in Patients With Diarrhea and BloatingNo drug interventionsNot AvailableNot Availablecompleted
NCT01424696
Baby Observational and Nutritional StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT04306939
Genomic Resources for Enhancing Available Therapies (GREAT1.0) StudyNo drug interventionsNot AvailableNot Availablesuspended
NCT00690820
Study Investigating a Delayed-Release Pancrelipase in Patients With Pancreatic Exocrine Insufficiency (PEI) Due to Cystic Fibrosis (CF)treatment3completed
NCT06119880
The Effect of PERT on Patients Undergoing Pancreaticoduodenectomytreatment4recruiting
NCT02563080
Pancreatic Exocrine Insufficiency in Acute PancreatitisNo drug interventionsNot AvailableNot Availablecompleted
NCT00449904
Open-Label Phase III Long-Term Safety Trial of Liprotamasetreatment3completed
NCT06278272
AI Evaluation of Pancreatic Exocrine Insufficiency in CP PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT05791110
PE-1 in the Diagnosis of Pancreatic Exocrine InsufficiencyNo drug interventionsdiagnosticNot Availablecompleted
NCT02734810
SIMPLICITY: Studying Impacts on Malabsorption With Liprotamase in Cystic FibrosisNo drug interventionstreatment3completed
NCT00414908
A Study to Investigate the Effect of Delayed Release Pancrelipase on Maldigestion in Patients With Exocrine Pancreatic Insufficiency Due to Chronic Pancreatitis and Pancreatectomytreatment3completed
NCT04690738
Role of Pancreatic Exocrine Secretion in Weight Gain After Pancreas TransplantationNo drug interventionsNot AvailableNot Availablerecruiting
NCT01327703
Control of Steatorrhea in Participants With Cystic Fibrosis and Exocrine Pancreatic InsufficiencyNo drug interventionstreatment4completed
NCT03051490
RESULT: Reliable, Emergent Solution Using Liprotamase TreatmentNo drug interventionstreatment3unknown_status
NCT00559364
Safety and Efficacy Study of Viokase® 16 for the Correction of Steatorrheatreatment3completed
NCT02823964
EASY: Extended Access to Sollpura Over YearsNo drug interventionstreatment4completed
NCT05980221
The Development of a Metabolomic Test to Diagnose and Quantify Pancreatic Exocrine Insufficiency (The DETECTION Study)No drug interventionsdiagnosticNot Availablerecruiting
NCT00676702
A Study of the Enzyme Activity and Safety of Pancrelipase in Patients With Severe Exocrine Pancreatic Insufficiency (EPI)Not Available1completed
NCT02279498
SOLUTION: Study of Oral Liprotamase Unit-Matched Therapy Of Non-Porcine Origin in Patients With Cystic FibrosisNo drug interventionstreatment3completed
NCT05261997
Endotherapy for Painless Chronic PancreatitistreatmentNot Availableunknown_status
NCT00743483
Efficacy of Bucelipase Alfa (BSSL) in Patients With Cystic Fibrosis and Pancreatic Insufficiencytreatment2completed
NCT05112328
The Effects of Pancreatic Enzyme Supplementation in Critically Ill Patients on Enteral FeedingNo drug interventionssupportive_careNot Availablerecruiting
NCT02598128
Safety, Tolerability and Fat Absorption Using Enteral Feeding In-line Enzyme Cartridge (Relizorb)No drug interventionstreatmentNot Availablecompleted
NCT05385211
Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and Exocrine Pancreatic Dysfunction in Type 1 DiabetesNo drug interventionsNot AvailableNot Availablecompleted
NCT06052293
Phase 1 Study to Assess Safety and Efficacy of ANG003No drug interventionstreatment1completed
NCT01131507
PR-018: An Open-Label, Safety Extension of Study PR-011treatment4completed
NCT02370537
A Study to Investigate How Common Pancreatic Exocrine Insufficiency (PEI) is in Patients With Type 2 Diabetes and Also to Investigate the Uptake of a Single Dose of EPANOVA® or OMACOR® in Patients With Different Degrees of PEItreatment2completed
NCT06477159
Pancreatic Enzyme Replacement Therapy for Acute Pancreatitis-Associated Exocrine Pancreatic Insufficiencytreatment4recruiting
NCT00663975
Open Label Safety Study of DCI-1020 in Pediatric Cystic Fibrosis (CF) PatientsNo drug interventionstreatmentNot Availablewithdrawn
NCT00749099
Bioavailability of Pancreatic Enzymes in the Human Upper Intestine (Duodenum and Jejunum)Not AvailableNot Availableterminated
NCT01100606
A Study to Evaluate the Mode of Administration and Safety of EUR-1008 (APT-1008) in Infants 1 to 12 Months of Agetreatment4completed
NCT04112836
Pancreatic Cancer Malnutrition and Pancreatic Exocrine Insufficiency in the Course of Chemotherapy in Unresectable Pancreatic CancerNo drug interventionsNot AvailableNot Availableunknown_status
NCT01427725
Special Investigation of LipaCreon on Long-term Use in Patients With Pancreatic Exocrine InsufficiencyNo drug interventionsNot AvailableNot Availablecompleted
NCT01747330
Evaluation of Safety and Tolerability of Creon Micro in Children Younger Than Four Years With Pancreatic Exocrine Insufficiencytreatment3completed
NCT05244174
Impact of Pancreatic Endoscopic Drainage on Exocrine Pancreatic Function in Unresectable Pancreatic CancerNo drug interventionstreatmentNot Availablerecruiting
NCT05450627
Registry of Pancreatic Exocrine Insufficiency.No drug interventionsNot AvailableNot Availableunknown_status
NCT00297167
Study to Evaluate the Safety and Efficacy of EUR-1008 (APT-1008) Pancreatic Enzyme Product in Participants With Cystic Fibrosis and Exocrine Pancreatic Insufficiencytreatment3completed
NCT06006312
Establishment and Clinical Application of Pancreatic Endocrine and Exocrine Function TestsNo drug interventionsNot AvailableNot Availablerecruiting
NCT01427712
Special Investigation (All Cases) of LipaCreon in Patients With Pancreatic Exocrine Insufficiency Due to Cystic FibrosisNot AvailableNot Availablecompleted
NCT00981214
Study of Pancreatic Enzyme Product in Pediatric Participants With Cystic Fibrosis and Exocrine Pancreatic Insufficiencytreatment3completed
NCT00744250
Intraduodenal Aspiration Study to Assess the Bioavailability of Oral Pancrecarb® Compared to Placebo Controlsupportive_care4terminated
NCT03236038
Prevalence of Exocrine Pancreatic Insufficiency in Patients With Decompensated CirrhosisNo drug interventionsNot AvailableNot Availablecompleted