Lipodystrophies (DBCOND0026618)

Identifiers

Synonyms
Lipodystrophy / Lipodystrophy, not elsewhere classified / Lipodystrophy (disorder) / Lipodystrophy acquired

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Tesamorelin
A growth hormone releasing factor (GRF) analog used to reduce excessive abdominal fat in HIV patients who have developed lipodystrophy.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT02034786
Safety Study of Filler Agent Composed of Autologous Mesenchymal Stem Cells and Hyaluronic AcidNo drug interventionstreatment1unknown_status
NCT00006290
Perceived Changes in Body Build and Image in Patients Who Are Now Taking or Recently Have Stopped Taking Anti-HIV DrugsNo drug interventionsNot AvailableNot Availablecompleted
NCT00006064
The Effect of Anti-HIV Treatment on Body Characteristics of HIV-Infected ChildrenNo drug interventionsNot AvailableNot Availablecompleted
NCT00005764
A Study of Increased Lactic Acid and Abnormal Fat Distribution in HIV-Positive Patientstreatment4completed
NCT00119379
Effectiveness of Nucleoside Supplementation or Switch to Tenofovir in Reversing Fat Loss in HIV Infected Adultstreatment2completed
NCT04656054
Hemoglobin Level, Coagulopathy Profile and Electrolyte BalanceNo drug interventionsNot AvailableNot Availableunknown_status
NCT03445351
Quality of Life, Sleep, and Biomarkers in People With HIV/AIDSNo drug interventionspreventionNot Availablecompleted
NCT05789251
Assess the Possibility of Diagnosing Diabetes and Rediabetes Following Oral Induced Hyperglycemia in Patients With Dunnigan's Partial Familial Lipodystrophy by Replacing 75 g of Glucose With a Standardized Carbohydrate Breakfast and Continuous Interstitial Monitoring Glucose)No drug interventionssupportive_careNot Availablerecruiting
NCT00123253
TH9507 in Patients With HIV-Associated Lipodystrophytreatment3completed
NCT00119405
Observational Study of Fat Loss in HIV Infected Adults Taking Nucleoside Reverse Transcriptase Inhibitors (NRTIs)No drug interventionsNot AvailableNot Availablecompleted
NCT01679197
Clinical Protocol to Investigate the Efficacy of Recombinant Human Leptin (Metreleptin) in Nonalcoholic Steatohepatitis (NASH) or Nonalcoholic Fatty Liver Disease (NAFLD) Associated With Lipodystrophytreatment2completed
NCT00025883
Leptin to Treat Lipodystrophytreatment2completed
NCT00865007
Lopinavir/r Monotherapy Versus Abacavir/Lamivudine and Lopinavir/r for Limb Fat Recovery in Persons With Lipoatrophyprevention4completed
NCT05239156
Evaluating the Performance and Safety of the Medical Device Janesse in the Treatment of Facial Dermal Tissue DefectsNo drug interventionstreatmentNot Availablecompleted
NCT00172315
Proton Magnetic Resonance Spectroscopy (1H MRS) in Evaluating the Bone Marrow, Muscle and Adipose Tissue on Normal and Human Immunodeficiency Virus Infected SubjectsNo drug interventionsNot AvailableNot Availableunknown_status
NCT05419037
Natural History of Pregnancy and Pregnancy Outcomes in Metreleptin-Treated vs Untreated Subjects With LipodystrophyNo drug interventionsNot AvailableNot Availablerecruiting
NCT02262832
Compassionate Use of Metreleptin in Previously Treated People With Generalized Lipodystrophytreatment3recruiting
NCT02494752
Role of Mesenchymal Stem Cells in Fat GraftingNo drug interventionstreatmentNot Availableunknown_status
NCT00822042
Corticosteroid-induced Lipodystrophy and AdipokinesNo drug interventionsNot AvailableNot Availablecompleted
NCT05996536
Feasibility of Adipose Tissue Triglyceride (TG) Labelling in Familial Partial Lipodystrophy (FPLD)No drug interventionsNot AvailableNot Availablerecruiting
NCT00677313
An Open-Label Treatment Protocol to Provide Metreleptin for the Treatment of Diabetes Mellitus and/or Hypertriglyceridemia Associated With LipodystrophyNo drug interventionstreatmentNot Availablecompleted
NCT00202241
The Effects of Anabolic Steroids and Protease Inhibitors on People Living With HIV/AIDSNo drug interventionsdiagnosticNot Availablecompleted
NCT01612858
Metabolic Abnormalities in HIV-infected Personstreatment4completed
NCT04860063
Effect of Berberine on Metabolic Syndrome, Efficacy and Safety in Combination With Antiretroviral Therapy in PLWH.treatment3unknown_status
NCT03900286
Low Energy Diet and Familial Partial LipodystrophyNo drug interventionstreatmentNot Availablerecruiting
NCT02639286
Efficacy, Safety and Tolerability of ISIS 304801 in People With Partial Lipodystrophy With an Open-Label Extensiontreatment2completed
NCT06107439
Impact of Lipodystrophy on the Inflammatory State of Non-diabetic Dunnigan Reunion Island SubjectsNo drug interventionshealth_services_researchNot Availablerecruiting
NCT00360139
Clinical Trial to Determine the Efficacy of Sculptra™ Dermal Filler for the Correction of Contour Deformities Caused by LipoatrophyNo drug interventionstreatment4withdrawn
NCT05402982
Intraoperative Fluid Management of Liposuction , Cardiometry Versus Rohrich FormulaNo drug interventionstreatmentNot Availablecompleted
NCT02614027
Prevalence of Lipodystrophy Syndrome and Its Role as Cause of Metabolic DisturbancesNo drug interventionsNot AvailableNot Availablecompleted
NCT03826160
Growth Hormone Dynamics and Cardiac Steatosis in HIVNo drug interventionsNot AvailableNot Availablecompleted
NCT00015691
Metformin and Rosiglitazone, Alone or in Combination, in HIV-Infected Patients With Insulin and Fat AbnormalitiestreatmentNot Availablecompleted
NCT01788462
Egrifta Replacement and Sleep Disordered BreathingNot AvailableNot Availablewithdrawn
NCT01784289
Adipocyte, Insulin-resistance and Immunity : Evaluation of Interleukin-7 in Lipodystrophy, Diabetes and ObesityNo drug interventionsNot AvailableNot Availablecompleted
NCT00119769
The Effect of Low-Dose Human Growth Hormone Therapy in HIV Infected Patientstreatment4completed
NCT00715546
Autologous Adipose-Derived Stem Cell Transplantation in Patients With LipodystrophyNo drug interventionstreatment1unknown_status
NCT02056912
Identification of a New Gene Involved in Hereditary LipodystrophyNo drug interventionsNot AvailableNot Availablecompleted
NCT00028314
Effects of Treatment Changes on Fat Wasting in the Arms and Legs of HIV PatientstreatmentNot Availablecompleted
NCT01093950
White Light Scanning to Aid Body Contouring: A Pilot ProjectNo drug interventionsNot AvailableNot Availableunknown_status
NCT00608023
TH9507 Extension Study in Patients With HIV-Associated LipodystrophyNo drug interventionstreatment3completed
NCT00006190
A Study to Determine How and Why HIV-Infected Subjects on Anti-viral Treatment Develop Lipodystrophydiagnostic4completed
NCT03059121
The Cleveland Cardiometabolic CohortNo drug interventionsNot AvailableNot Availablerecruiting
NCT00192621
Seronegatives and Metabolic Abnormalities Protocol 2 (SAMA002): Study to Compare the Effect of Kaletra and Combivir® in HIV-Negative Healthy Subjectsbasic_science4completed
NCT04578379
Insulin Regulated Amino Peptidase in Patients With Familial Lipodystrophy of DUNNIGANNo drug interventionsNot AvailableNot Availablecompleted
NCT05239351
Evaluating Performance and Safety of the Medical Device Jalucomplex in the Treatment of Facial and Neck Tissue DefectsNo drug interventionstreatmentNot Availablecompleted
NCT02647853
Phase 1 Study to Assess the Safety and Tolerability of TAT4 Gel in Healthy VolunteersNo drug interventionstreatment1completed
NCT00005905
Leptin to Treat Lipodystrophytreatment2completed
NCT02492997
Clinical Evaluation of Venus Versa Octipolar Applicator for Reduction of Abdomen CircumferenceNo drug interventionstreatmentNot Availableterminated
NCT00082628
Treatment of Abnormal Adipose Tissue Accumulation in Human Immunodeficiency Virus (HIV) Patientstreatment3completed
NCT00202228
Lactate Metabolism Study in HIV Infected Personshealth_services_research4completed
NCT01778556
Short-term Effects of Leptin in People With LipodystrophyNo drug interventionstreatment2completed
NCT00006185
Underlying Abnormalities in Fat and Muscle Leading to Lipodystrophy Syndromediagnostic1completed
NCT02258685
Factors Mediating Gut Microbiota Dysbiosis and Metabolic Disease in HIV Patients.No drug interventionsNot AvailableNot Availablecompleted
NCT06236932
Susceptibility to Infectious Diseases in obEsity: an endocRine trAnslational socioLogic Evaluation, "SIDERALE"No drug interventionsdiagnosticNot Availablerecruiting
NCT02577952
Lipodystrophy Connect Patient RegistryNo drug interventionsNot AvailableNot Availablecompleted
NCT00461552
Therapeutic Approaches to HAART-Induced LipodystrophyNo drug interventionstreatment2completed
NCT00227500
Pravastatin for Hyperlipidaemia in HIV.treatment4completed
NCT06089759
Performance and Safety of the Lipo-transfer Cannulas in Patients Underlying Lipofilling TreatmentNo drug interventionsNot AvailableNot Availablecompleted
NCT03275259
Shock Waves for Treatment of Gynoid Lipodystrophy and Localized FatNo drug interventionstreatmentNot Availablecompleted
NCT00656175
Raltegravir Therapy for Women With HIV and Fat AccumulationNo drug interventionstreatment2completed
NCT00001142
Metabolism and Body Shape of Healthy Children and Children With Chronic InfectionsNo drug interventionsNot AvailableNot Availablecompleted
NCT02262806
Compassionate Use of Metreleptin in Previously Treated People With Partial LipodystrophyNo drug interventionstreatment2active_not_recruiting
NCT05930106
Carotid Doppler Peak Velocity Variation in Liposuction Fluid ManagementNo drug interventionstreatmentNot Availablerecruiting
NCT00910936
Exercise for Patients With HIV InfectionsNo drug interventionssupportive_care2 / 3unknown_status
NCT05424913
Exploratory Study of the Relationships Between the Biomarkers of Inflammation, Lipidome and Insulin Resistance and Disorders of Glycemic Regulation in a Cohort of Insulin-resistant Subjects Due to Excess Weight or Dunnigan's LipodystrophyNo drug interventionsotherNot Availablecompleted
NCT03407313
CONFORM: Rotational Fractional Resection for Submental ContouringNo drug interventionstreatmentNot Availablecompleted
NCT05239117
Evaluating the Performance and Safety of the Medical Device Plenhyage® in the Treatment of Dermal Tissue DefectsNo drug interventionstreatmentNot Availableunknown_status
NCT03966924
The PREFORM Study: Rotational Fractional Resection for Submental ContouringNo drug interventionstreatmentNot Availablecompleted
NCT00426296
SHARE: Simple HAART With Abacavir, Reyataz, and EpivirNo drug interventionstreatment4unknown_status
NCT00017758
The Effect of Efavirenz and Nelfinavir on the Blood Levels of Certain Lipid-Lowering Drugstreatment1completed
NCT00021463
Changing to Nonprotease Inhibitor Treatment to Improve Side Effectstreatment2completed
NCT05239130
Evaluating the Performance and Safety of the Medical Device Auralya® in the Treatment of Facial Dermal Tissue DefectsNo drug interventionstreatmentNot Availableunknown_status
NCT00331448
Observational Study of Changes in Fat Distribution and Blood Metabolites in HIV Infected AdultsNo drug interventionsNot AvailableNot Availableunknown_status
NCT00639457
Exercise and Pioglitazone for HIV-Metabolic SyndromesNo drug interventionstreatmentNot Availablecompleted
NCT00004329
Study of Alpha-2 Adrenergic Receptor Dysfunction in Regional LipoatrophyNo drug interventionsNot AvailableNot Availablecompleted
NCT00069004
A Study of Physical and Metabolic Abnormalities in HIV Infected and Uninfected Children and YouthNo drug interventionsNot AvailableNot Availablecompleted
NCT00647946
Study to Evaluate Changes in Limb Fat When Switching From a Thymidine AnalogueNo drug interventionstreatment2completed
NCT00006412
Safety and Effectiveness of Fenofibrate and Pravastatin in HIV-Positive Patients With Abnormal Blood Lipidstreatment3completed