Nausea and vomiting (DBCOND0028521)

Identifiers

Synonyms

Nausea and/or vomiting / Nausea or vomiting / Nausea with vomiting / Nausea and vomiting symptoms / Nausea/Vomiting / Nausea & vomiting / Nausea with vomiting, unspecified / Nausea and vomiting (disorder) / Vomiting, unspecified / Vomiting / Vomiting (disorder) / Vomiting NOS / Vomited / Emesis / Vomiting symptoms (disorder) / Finding of vomiting (finding)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Alizapride	A dopamine antagonist used to prevent nausea and vomiting associated with medical procedures, surgeries, and cancer therapies.	D(2) dopamine receptortarget
Chlorpromazine	A phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children.	D(2) dopamine receptortarget 5-hydroxytryptamine receptor 2Atarget Cytochrome P450 2D6enzyme Cholinesteraseenzyme Cytochrome P450 1A2enzyme Albumincarrier ATP-dependent translocase ABCB1transporter D(1A) dopamine receptortarget 5-hydroxytryptamine receptor 1Atarget Alpha-1A adrenergic receptortarget Alpha-1B adrenergic receptortarget Cytochrome P450 2E1enzyme Cytochrome P450 3A4enzyme Histamine H1 receptortarget Potassium voltage-gated channel subfamily H member 2target D(1) dopamine receptortarget D(3) dopamine receptortarget D(4) dopamine receptortarget D(1B) dopamine receptortarget 5-hydroxytryptamine receptor 2Ctarget 5-hydroxytryptamine 2 receptortarget Alpha-1 adrenergic receptorstarget Alpha-2 adrenergic receptorstarget Muscarinic acetylcholine receptor M1target Muscarinic acetylcholine receptor M3target Sphingomyelin phosphodiesterasetarget alpha1-acid glycoproteintarget 5-hydroxytryptamine receptor 6target 5-hydroxytryptamine receptor 7target Histamine H4 receptortarget Bile salt export pumptransporter Calmodulintarget
Clebopride	A dopamine antagonist used to treat symptoms associated with functional gastrointestinal disorders. Clebopride may also be used to treat nausea and vomiting associated with chemotherapy.	D(2) dopamine receptortarget Acetylcholinesterasetarget
Dimenhydrinate	A medication used to prevent and treat nausea, vomiting, vertigo, and motion sickness.	Histamine H1 receptortarget
Droperidol	A butyrophenone derivative and dopamine antagonist used to prevent and treat postoperative nausea and vomiting.	D(2) dopamine receptortarget Alpha-1A adrenergic receptortarget
Granisetron	A 5HT3 antagonist used to treat nausea and vomiting in cancer therapy and postoperatively.	5-hydroxytryptamine receptor 3Atarget Cytochrome P450 3A4enzyme Cytochrome P450 1A1enzyme
Haloperidol	An antipsychotic agent used to treat schizophrenia and other psychoses, as well as symptoms of agitation, irritability, and delirium.	D(2) dopamine receptortarget Glutamate receptor ionotropic, NMDA 2Btarget D(1A) dopamine receptortarget Cytochrome P450 1A2enzyme Cytochrome P450 2D6enzyme 5-hydroxytryptamine receptor 2Atarget D(3) dopamine receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter Carbonyl reductase [NADPH] 1enzyme UDP-glucuronosyltransferase 1A9enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C9enzyme Melanin-concentrating hormone receptor 1target Synaptic vesicular amine transportertarget 5-hydroxytryptamine receptor 2Ctarget Sigma non-opioid intracellular receptor 1target Histamine H1 receptortarget Muscarinic acetylcholine receptor M3target Alpha-1A adrenergic receptortarget Alpha-2A adrenergic receptortarget Alpha-2B adrenergic receptortarget Alpha-2C adrenergic receptortarget 5-hydroxytryptamine receptor 1Atarget 5-hydroxytryptamine receptor 6target 5-hydroxytryptamine receptor 7target Cytochrome P450 1A1enzyme
Hydroxyzine	An antihistamine used to treat anxiety and tension associated with psychoneuroses, as well as allergic conditions such as pruritus and chronic urticaria.	Histamine H1 receptortarget Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Potassium voltage-gated channel subfamily H member 2target ATP-dependent translocase ABCB1transporter Albumincarrier
Itopride	An acetylcholine esterase inhibitor and dopamine D2 receptor antagonist used to treat symptoms of functional dyspepsia such as nausea and vomiting.	D(2) dopamine receptortarget Acetylcholinesterasetarget
Levosulpiride	indicated to treat dyspepsia, symptoms of Meniere's syndrome, and second line in the treatment of drug-induced nausea and vomiting.	No drug targets
Methotrimeprazine	A phenothiazine used in the management of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder.	D(3) dopamine receptortarget Histamine H1 receptortarget Muscarinic acetylcholine receptor M1target Muscarinic acetylcholine receptor M2target Muscarinic acetylcholine receptor M3target Muscarinic acetylcholine receptor M4target Muscarinic acetylcholine receptor M5target Alpha-1A adrenergic receptortarget Alpha-1B adrenergic receptortarget Alpha-1D adrenergic receptortarget Cytochrome P450 2D6enzyme D(2) dopamine receptortarget D(1A) dopamine receptortarget D(1B) dopamine receptortarget D(4) dopamine receptortarget Alpha-2A adrenergic receptortarget Alpha-2B adrenergic receptortarget Alpha-2C adrenergic receptortarget 5-hydroxytryptamine receptor 2Atarget 5-hydroxytryptamine receptor 2Ctarget Cytochrome P450 2E1enzyme
Metoclopramide	An antiemetic agent and dopamine D2 antagonist used in the treatment of gastroesophageal reflux disease, prevention of nausea and vomiting, and to stimulate gastric emptying.	Muscarinic acetylcholine receptor M1target D(2) dopamine receptortarget Cytochrome P450 2D6enzyme 5-hydroxytryptamine receptor 4target 5-hydroxytryptamine receptor 3Atarget Cytochrome P450 3A4enzyme Cytochrome P450 1A2enzyme ATP-dependent translocase ABCB1transporter Alpha-1-acid glycoprotein 1carrier
Pyridoxine	A vitamin used to correct vitamin B6 deficiency and to treat nausea during pregnancy.	Pyridoxal kinasetarget Cytochrome P450 1A1enzyme Albumincarrier Pyridoxal kinaseenzyme Chronophinenzyme Alkaline phosphatase, tissue-nonspecific isozymetransporter Alkaline phosphatase, tissue-nonspecific isozymeenzyme Aromatic-L-amino-acid decarboxylasetarget
Thiethylperazine	A drug used for the treatment of nausea and vomiting.	D(2) dopamine receptortarget
Trimethobenzamide	An antiemetic used to treat postoperative nausea and vomiting and nausea associated with gastroenteritis.	No drug targets

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00895245	Fosaprepitant Dimeglumine, Palonosetron Hydrochloride, and Dexamethasone in Preventing Nausea and Vomiting Caused by Cisplatin in Patients With Stage III or Stage IV Head and Neck Cancer Undergoing Chemotherapy and Radiation Therapy	Cisplatin Dexamethasone Fosaprepitant Palonosetron	supportive_care	2	terminated
NCT00903305	Nurse-Provided Care or Standard Care in Treating Patients With Stage I, Stage II, or Stage III Breast Cancer	No drug interventions	health_services_research	Not Available	withdrawn
NCT00891761	A Study of IV Casopitant for the Prevention of Nausea and Vomiting Caused By Cisplatin-Based Highly Emetogenic Chemotherapy	Casopitant Dexamethasone Ondansetron	supportive_care	3	withdrawn
NCT06282211	the Efficacy and Safety of Ondansetron Oral Soluble Pellicles	Ondansetron	treatment	3	recruiting
NCT02026778	Comparison of the Effect of Ondansetron and Combined Ondansetron and Betahistine on Postoperative Nausea and Vomiting After Gynecological Laparoscopy	Betahistine Ondansetron	prevention	Not Available	completed
NCT05837156	A Clinical Study to Evaluate Cyclopofol Injection for the Prevention of Postoperative Nausea and Vomiting	No drug interventions	prevention	1	enrolling_by_invitation
NCT00978185	Acupressure Wristbands or Standard Care in Controlling Nausea Caused by Chemotherapy	No drug interventions	supportive_care	3	completed
NCT01718132	Reduction of Postoperative Pain, Nausea and Vomiting	No drug interventions	Not Available	Not Available	completed
NCT00978549	Symptom Control With or Without Docetaxel in Treating Patients With Relapsed Esophageal Cancer or Stomach Cancer	Docetaxel	treatment	3	completed
NCT01669213	Effects of Different Kinds, Different Doses of 5-HT3 Receptor Antagonists on Prevention of Hypotension	Ondansetron Ramosetron	prevention	Not Available	unknown_status
NCT00590317	Ondansetron vs Prochlorperazine for Nausea and Vomiting in the Emergency Department	Ondansetron Prochlorperazine	treatment	2	completed
NCT01696734	Domperidone in Treating Patients With Gastrointestinal Disorders	Domperidone	treatment	3	recruiting
NCT00310063	Acupressure in Preventing Nausea and Vomiting in Young Cancer Patients Receiving Chemotherapy	No drug interventions	supportive_care	Not Available	completed
NCT00179348	Yoga-Based Rehabilitation Program in Reducing Physical and Emotional Side Effects in Patients With Cancer	No drug interventions	supportive_care	Not Available	completed
NCT00006348	Ondansetron in Treating Patients With Advanced Cancer and Chronic Nausea and Vomiting Not Caused by Cancer Treatment	Ondansetron	supportive_care	3	completed
NCT00020657	Comparison of Antiemetic Drugs in Preventing Delayed Nausea After Chemotherapy in Patients With Cancer	Dolasetron Granisetron Ondansetron Prochlorperazine	supportive_care	3	completed
NCT00719173	Effect of Aprepitant on Cyclophosphamide Pharmacokinetics in Patients With Breast Cancer	Aprepitant Cyclophosphamide	treatment	1	completed
NCT00005994	Patient Education in Preventing Nausea and Vomiting in Cancer Patients Receiving Chemotherapy	Ondansetron	Not Available	Not Available	completed
NCT00381862	Phase II Trial of Aprepitant & Palonosetron for CINV Prevention w FOLFOX	Aprepitant Camptothecin Dexamethasone Fluorouracil Fosaprepitant Irinotecan Leucovorin Oxaliplatin Palonosetron	supportive_care	2	completed
NCT00748267	Hypnosis in Reducing Pain and Other Side Effects in Women Undergoing Surgery for Breast Cancer	No drug interventions	supportive_care	Not Available	completed
NCT00064272	UMCCOP 02-01 Ginger in Treating Nausea and Vomiting in Patients Receiving Chemotherapy for Cancer	No drug interventions	supportive_care	2	completed
NCT00900068	Blood Samples From Patients on a Clinical Trial to CINV During HSCT	No drug interventions	Not Available	Not Available	terminated
NCT06382012	Antiemetic Fosaprepitant To Remedy Nausea and Vomiting	Fosaprepitant Ondansetron	treatment	2 / 3	not_yet_recruiting
NCT00004895	Octreotide as Palliative Therapy for Cancer-Related Bowel Obstruction That Cannot Be Removed by Surgery	Octreotide	supportive_care	2	completed
NCT04560114	Effect of Inhaled Aromatherapy on Chemo-Induced Nausea Vomiting (NCVI): CINVAROM (Chemotherapy Induced Nausea Vomiting and AROMatherapy)	No drug interventions	treatment	2	completed
NCT06045364	Effect of Glycopyrrolate on Nausea and Vomiting After ERCP Operation	Anisodamine Glycopyrronium	treatment	1 / 2	completed
NCT01275664	Granisetron, Aprepitant, and Dexamethasone in Preventing Nausea and Vomiting in Patients Receiving Chemotherapy for Stage II, III, or IV Ovarian Cancer	Aprepitant Carboplatin Chloride ion Cisplatin Dexamethasone Granisetron Platinum	supportive_care	Not Available	terminated
NCT06415084	Prevalence of Hyperemesis Gravidarum	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT01372787	Quality of Life and Care Needs of Patients With Persistent or Recurrent Ovarian Cancer, Fallopian Tube Cancer, or Peritoneal Cancer	No drug interventions	Not Available	Not Available	unknown_status
NCT00902733	Nurse-Provided Care or Standard Care in Treating Patients With Pancreatic Cancer	No drug interventions	health_services_research	Not Available	completed
NCT01590147	Supportive Intervention Programs Study	No drug interventions	supportive_care	Not Available	completed
NCT01553578	Healing Touch or Guided Imagery In Treating Pain, Fatigue, Nausea, and Anxiety in Patients Undergoing Chemotherapy	No drug interventions	supportive_care	Not Available	completed
NCT00418678	A Phase IV Trial of Cesamet™ Given With Standard Antiemetic Therapy for Chemotherapy-induced Nausea and Vomiting	Nabilone	treatment	4	terminated
NCT03185156	The Preventive Effects of Sub Hypnotic Dose of Propofol for Nausea and Vomiting Induced by Hemabate	Propofol	prevention	4	completed
NCT00003685	Radiation Therapy to Relieve Symptoms in Patients With Non-small Cell Lung Cancer	No drug interventions	treatment	3	completed
NCT00930332	Methadone Hydrochloride as First-Line Therapy in Treating Patients With Chronic Neuropathic Cancer Pain	Methadone	supportive_care	1	terminated
NCT06314906	Electroacupuncture Plus Antiemetic Therapy for Chemotherapy-Induced Nausea and Vomiting in Patients With Breast Cancer	No drug interventions	treatment	3	recruiting
NCT00003213	Drugs to Reduce the Side Effects of Chemotherapy	Dexamethasone Granisetron Metoclopramide	supportive_care	3	completed
NCT00004219	Lerisetron Compared With Granisetron in Preventing Nausea and Vomiting in Men Being Treated With Radiation Therapy for Stage I Seminoma	Granisetron Lerisetron	supportive_care	3	unknown_status
NCT02550119	Dolasetron Mesylate and Dexamethasone With or Without Aprepitant in Preventing Nausea and Vomiting in Patients Undergoing Oxaliplatin-Containing Chemotherapy for Gastrointestinal Malignancy	Aprepitant Dexamethasone Dolasetron	supportive_care	Not Available	terminated
NCT00003817	Acupressure and Acustimulation Wrist Bands for the Prevention of Nausea and Vomiting Caused by Chemotherapy	Dolasetron Granisetron Ondansetron Tropisetron	supportive_care	2	completed
NCT00903396	Palonosetron Hydrochloride in Preventing Nausea and Vomiting Caused by Radiation Therapy in Patients With Primary Abdominal Cancer	Palonosetron	supportive_care	2	terminated
NCT00343863	Dexamethasone and Ondansetron Hydrochloride or Palonosetron Hydrochloride in Preventing Nausea and Vomiting in Patients Receiving Doxorubicin Hydrochloride and Cyclophosphamide For Early Stage Breast Cancer	Cyclophosphamide Dexamethasone Doxorubicin Ondansetron Palonosetron	supportive_care	Not Available	completed
NCT02116530	Antiemetic Therapy With or Without Olanzapine in Preventing Chemotherapy-Induced Nausea and Vomiting in Patients With Cancer Receiving Highly Emetogenic Chemotherapy	Aprepitant Cisplatin Cyclophosphamide Dexamethasone Doxorubicin Fosaprepitant Granisetron Olanzapine Ondansetron Palonosetron	supportive_care	3	completed
NCT00343460	APF530 or Aloxi (Palonosetron Hydrochloride) Combined With Dexamethasone in Preventing Nausea and Vomiting in Patients Receiving Chemotherapy for Cancer	Dexamethasone Granisetron Palonosetron	supportive_care	3	completed
NCT00880191	Gabapentin in Preventing Nausea and Vomiting in Patients Receiving Chemotherapy	Dexamethasone Gabapentin	supportive_care	3	completed
NCT05016180	Effect of Ultrasound-guided Transversus Abdominis Plane Block After Laparoscopic Bariatric Surgery	Ropivacaine	prevention	2	unknown_status
NCT00416689	Nausea or Vomiting in Patients Who Are Receiving Chemotherapy for Breast Cancer or Lung Cancer	No drug interventions	Not Available	Not Available	completed
NCT00169572	Study for The Prevention Of Nausea in Cancer Patients Receiving Highly Emetogenic Cisplatin Based Chemotherapy	Aprepitant Casopitant Dexamethasone Ondansetron	treatment	2	completed
NCT06200168	Electroacupuncture for the Prevention of Chemotherapy-induced Nausea and Vomiting in Patients With Breast Cancer	No drug interventions	treatment	3	recruiting
NCT00499668	Aprepitant or Ondansetron in Treating Nausea and Vomiting Caused By Opioids in Patients With Cancer	Aprepitant Ondansetron	supportive_care	Not Available	withdrawn
NCT05533281	Efficacy of Three Antiemetics in Preventing Nausea and Vomiting	Dexamethasone Metoclopramide Tropisetron	prevention	4	completed
NCT05690802	The Safety and Effectiveness of Palonosetron Hydrochloride Capsule Was Used to CINV	Palonosetron	treatment	Not Available	recruiting
NCT00293384	Aprepitant, Granisetron, & Dexamethasone in Preventing Nausea & Vomiting in Pts. Receiving Cyclophosphamide Before a Stem Cell Transplant	Aprepitant Cyclophosphamide Dexamethasone Granisetron	supportive_care	Not Available	completed
NCT01890499	Prospective Controlled Trial On Clear Feeds Versus Low Residue Diet After Surgery In Elective Colorectal Surgery Patients	No drug interventions	treatment	Not Available	completed
NCT03260426	Trial of Low Residue Diet Versus Clear Liquids Following Elective Colorectal Surgery	No drug interventions	treatment	Not Available	completed
NCT03262038	Does IV Ondansetron Prevent Pruritus After Intrathecal Morphine in Pediatric Patients?	Ondansetron	prevention	4	terminated