Metastatic Melanoma (DBCOND0030058)

Identifiers

Synonyms
Metastatic Melanoma Stage IV / Metastatic Melanoma (MEL) / Metastatic melanoma / Malignant melanoma, metastatic (morphologic abnormality) / Metastatic malignant melanoma / Metastatic malignant melanoma (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Aldesleukin
A recombinant analog of interleukin-2 used to induce an adaptive immune response in the treatment of renal cell carcinoma.
Atezolizumab
A monoclonal antibody used to treat advanced or metastatic urothelial carcinoma with disease progression during or up to 12 months after platinum-containing chemotherapy.
Binimetinib
A medication used to treat metastatic melanoma with specific mutations.
Cobimetinib
An antineoplastic agent and selective inhibitor of the mitogen-activated extracellular kinase (MEK) pathway used to treat unresectable or metastatic melanoma.
Dabrafenib
A kinase inhibitor used to treat patients with specific types of melanoma, non-small cell lung cancer, and thyroid cancer.
Dacarbazine
An antineoplastic agent used to treat malignant melanoma and Hodgkin's disease.
Encorafenib
A kinase inhibitor used to treat unresectable or metastatic melanoma with specific mutations.
Fotemustine
An alkylating agent used in the treatment of metastatic melanoma.
Imatinib
A tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors.
Ipilimumab
A human cytotoxic T-lymphocyte antigen 4 (CTLA-4) blocking antibody used to treat metastatic or unresectable melanoma.
Lifileucel
An autologous T cell immunotherapy used to treat unresectable or metastatic melanoma in previously treated adults.
No drug targets
Nivolumab
A PD-1 blocking antibody used to treat melanoma, non small-cell lung cancer, renal cell cancer, head and neck cancer, and Hodgkin lymphoma.
Paclitaxel
A taxoid chemotherapeutic agent used as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary, and other various cancers including breast and lung cancer.
Pembrolizumab
A PD-1 blocking antibody used to treat various types of cancer, including metastatic melanoma, non small-cell lung cancer, cervical cancer, head and neck cancer, and Hodgkin's lymphoma.
Relatlimab
A monoclonal antibody targeted against LAG-3 which is used in combination with nivolumab for the treatment of unresectable or metastatic melanoma.
Trametinib
A kinase inhibitor used alone or in combination with dabrafenib to treat patients with cancers with specific BRAF mutations, such as melanoma and non-small cell lung cancer.
Vemurafenib
A kinase inhibitor used to treat patients with Erdheim-Chester Disease who have the BRAF V600 mutation, and melanoma in patients who have the BRAF V600E mutation.
Vinblastine
A vinca alkaloid used to treat breast cancer, testicular cancer, neuroblastoma, Hodgkin's and non-Hodgkins lymphoma, mycosis fungoides, histiocytosis, and Kaposi's sarcoma.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT02259231
RTA 408 Capsules in Patients With Melanoma - REVEALtreatment1 / 2completed
NCT02076646
A Phase I/II Dose Escalation Study of the Tumor-targeting Human L19-IL2 Monoclonal Antibody-cytokine Fusion Protein in Combination With Dacarbazine for Patients With Metastatic Melanomatreatment1 / 2unknown_status
NCT02133222
Circulating Cell-free DNA in Metastatic Melanoma Patient: Mutational Analyses in Consecutive Measurement Before and After ChemotherapyNo drug interventionsscreeningNot Availablecompleted
NCT05848739
A Phase 1-2 of ST316 With Selected Advanced Unresectable and Metastatic Solid Tumorstreatment1recruiting
NCT00730639
A Phase 1 Study of Nivolumab (BMS-936558) in Subjects With Advanced or Recurrent Malignanciestreatment1completed
NCT05896839
Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancertreatment1 / 2recruiting
NCT01032122
Rituximab in Metastatic Melanomatreatment1terminated
NCT01055522
Clinical Study Phase II of L19IL2 in Combination With Dacarbazine in Patients With Metastatic Melanomatreatment2terminated
NCT00747825
Phase I Safety and Dosimetry Study in Patients With Confirmed Metastatic Melanomadiagnostic1terminated
NCT00304525
A Study to Evaluate RAF265, an Oral Drug Administered to Subjects With Locally Advanced or Metastatic Melanomatreatment1 / 2completed
NCT04941430
7T MRI Scan for the Early Detection of Melanoma Brain MetastasesNo drug interventionsdiagnosticNot Availablerecruiting
NCT00670748
Chemotherapy Followed by ESO-1 Lymphocytes and Aldesleukin to Treat Metastatic Cancertreatment2terminated
NCT04616248
In Situ Immunomodulation With CDX-301, Radiation Therapy, CDX-1140 and Poly-ICLC in Patients w/ Unresectable and Metastatic Solid Tumorstreatment1recruiting
NCT02038348
Interest of the 18F-DOPA-PET Imaging in Metastatic Melanoma Treated With B-RAF Inhibitors: a Pilot StudyNo drug interventionsprevention2completed
NCT01740557
Genetically Modified Therapeutic Autologous Lymphocytes Followed by Aldesleukin in Treating Patients With Stage III or Metastatic Melanomatreatment1 / 2completed
NCT04703426
Sargramostim (GM-CSF) + PD-1treatment2withdrawn
NCT06424626
A Trial of AK104 or AK112 in Combination With Axitinib in Patients With Metastatic Mucosal Melanomatreatment1not_yet_recruiting
NCT03415126
A Study of ASN007 in Patients With Advanced Solid TumorsNo drug interventionstreatment1completed
NCT05510466
Triple BRAFinh/MEKinh /antiPD1 Combined Therapy in Patients With BRAF Mutated Melanoma With Central Nervous System MetastasisNo drug interventionsNot AvailableNot Availableunknown_status
NCT02065466
Combo of Abraxane, TMZ, Bevacizumab in Metastatic Melanoma With Brain Metastasestreatment1 / 2withdrawn
NCT02489266
In Vivo Persistence of Adoptively-Transferred TIL Cultured With Akti in People With Metastatic Melanomatreatment1withdrawn
NCT02595866
Testing the Addition of an Experimental Medication MK-3475 (Pembrolizumab) to Usual Anti-Retroviral Medications in Patients With HIV and Cancertreatment1completed
NCT01042366
Dendritic Cells (DC) Vaccine for Metastatic MelanomaNo drug interventionstreatment2terminated
NCT01280565
Masitinib in Non-Resectable or Metastatic Stage 3/4 Melanoma Carrying a Mutation in the Juxta Membrane Domain of c-Kittreatment3terminated
NCT02626065
Immune Modulation Study in Patients With Metastatic Melanoma Treated With Anti-PD1 Monoclonal Antibodiesother4unknown_status
NCT00414765
Aldesleukin in Participants With Metastatic Renal Cell Carcinoma or Metastatic Melanomatreatment4completed
NCT01701674
Ipilimumab With Lymphodepletion Plus Adoptive Cell Transfer and High Dose IL-2 in Melanoma Mets PtstreatmentNot Availableactive_not_recruiting
NCT05361174
A Study to Investigate the Efficacy and Safety of an Infusion of IOV-4001 in Adult Participants With Unresectable or Metastatic Melanoma or Stage III or IV Non-small-cell Lung CancerNo drug interventionstreatment1 / 2recruiting
NCT01689974
Phase II Randomized Trial of Ipilimumab Versus Ipilimumab and Radiotherapy in Metastatic Melanomatreatment2terminated
NCT02740920
Response to Pembrolizumab in Metastatic Melanoma: Computed Tomography Texture Analysis as a Predictive Biomarkertreatment2terminated
NCT02158520
Nab-Paclitaxel and Bevacizumab or Ipilimumab as First-Line Therapy in Treating Patients With Stage IV Melanoma That Cannot Be Removed by Surgerytreatment2completed
NCT02054520
Immunotherapy Study for Patients With Stage IV Melanomatreatment2terminated
NCT03597282
A Personal Cancer Vaccine (NEO-PV-01) and APX005M or Ipilimumab With Nivolumab in Patients With Advanced Melanomatreatment1terminated
NCT04337931
A Study to Evaluate Sotigalimab (APX005M) in Subjects With Unresectable or Metastatic Melanomatreatment2terminated
NCT00287131
Adoptive Cell Therapy Following Non-myeloablate Chemotherapy in Metastatic Melanoma PatientsNo drug interventionstreatment2unknown_status
NCT01236573
Cell Therapy for Metastatic Melanoma Using CD8 Enriched Tumor Infiltrating Lymphocytestreatment1 / 2terminated
NCT04217473
TNFalpha and Interleukin 2 Coding Oncolytic Adenovirus TILT-123 During TIL Treatment of Advanced Melanomatreatment1active_not_recruiting
NCT03326973
Long-Term Quality of Life in Patients With Metastatic Melanoma Treated With Checkpoint InhibitorsNo drug interventionsNot AvailableNot Availablecompleted
NCT01029873
QUILT-2.008: Study of ALT-801 With Cisplatin in Patients With Metastatic Melanomatreatment1 / 2completed
NCT01503827
Whole Brain Radiotherapy Following Local Treatment of Intracranial Metastases of MelanomaNo drug interventionstreatmentNot Availableunknown_status
NCT04697576
Intralesional Influenza Vaccine for the Treatment of Stage I-IV Melanomatreatment1recruiting
NCT06236360
Metastatic Melanoma Patients on Immunotherapy With Nutritive Intervention Based on Mediterranean DietNo drug interventionssupportive_careNot Availablerecruiting
NCT03021460
Pembrolizumab and Ibrutinib in Treating Patients with Stage III-IV Melanoma That Cannot Be Removed by SurgeryNo drug interventionstreatment1active_not_recruiting
NCT00716560
Nausea and Vomiting In Patients Receiving Consecutive Days of CisplatinNo drug interventionsNot AvailableNot Availableterminated
NCT02791594
Imaging FDG Flare in MelanomaNot AvailableNot Availablecompleted
NCT03850691
Radiation and Combination Immunotherapy for Melanomatreatment2completed
NCT05103891
Relative Bioavailability of Binimetinib 3 x 15 mg and 45 mg Formulationsother1unknown_status
NCT01692691
Dacarbazine and Carmustine in Metastatic Melanomatreatment2terminated
NCT02117362
Galectin Inhibitor (GR-MD-02) and Ipilimumab in Patients With Metastatic Melanomatreatment1completed
NCT03698162
Precise DCE-MRI in Diagnosing Participants With Recurrent High Grade Glioma or Melanoma Brain MetastasesdiagnosticNot Availableterminated
NCT00249262
Taxoprexin Treatment for Advanced Skin MelanomaNo drug interventionstreatment2completed
NCT04955262
A CD8 Positron Emission Tomography With Computed Tomography (PET/CT) Study Using ⁸⁹Zr Df-IAB22M2C in Patients With Metastatic Melanoma Receiving Bempegaldesleukin (NKTR-214) and Nivolumabtreatment1withdrawn
NCT04645680
Effect of Diet on the Immune System in Patients With Stage III-IV Melanoma Receiving Immunotherapy, DIET StudyNo drug interventionssupportive_care2active_not_recruiting
NCT00121680
A Phase I/Ib, Multicenter, Open-Label, Dose Escalation Study of E7080 in Patients With Solid Tumors and in Combination With Temozolomide in Patients With Advanced and/or Metastatic Melanomatreatment1completed
NCT03149029
Abbreviated MAPK Targeted Therapy Plus Pembrolizumab in Melanomatreatment2active_not_recruiting
NCT05611229
Treatment Patterns and Outcomes of Targeted Therapy and Immunotherapy Among BRAF-Positive Melanoma Patients Treated in the Adjuvant Setting and Among BRAF-Positive Metastatic Melanoma Patients With Low Tumor BurdenNot AvailableNot Availablecompleted
NCT01932489
The Jules Bordet Institute Molecular Profiling Program Feasibility TrialNo drug interventionsotherNot Availablecompleted
NCT00679289
Phase II Study of KW2871 Combined With High Dose Interferon-α2b in Patients With Metastatic Melanomatreatment2completed
NCT05717140
Aerosolized Sargramostim Added to Immunotherapy for the Treatment of Patients With Metastatic Melanoma to the Lungtreatment1not_yet_recruiting
NCT05398640
Expanded Access Program of Lifileucel (LN-144) in Patients With Unresectable or Metastatic MelanomaNot AvailableNot Availableno_longer_available
NCT05810740
Bioequivalence Binimetinib 3 x 15 mg and 45 mg Formulationsother1completed
NCT04752267
18F-FMAU PET/CT and MRI for the Detection of Brain Tumors in Patients With Brain Cancer or Brain Metastasesdiagnostic0completed
NCT01833767
Low-dose Cyclophosphamide and Outpatient IV Interleukin-2 in Metastatic Melanomatreatment2withdrawn
NCT00301067
Phase I/II Study of High-Dose Calcitriol Plus Temodar for Patients With Metastatic Melanomatreatment1 / 2completed
NCT03013101
Safety and Efficacy of Recombinant Humanized Anti-PD-1 mAb for Patients With Locally Advanced or Metastatic Melanomatreatment2unknown_status
NCT03514901
To Evaluate the Efficacy Beyond Progression of Vemurafenib+Cobimetinib Associated With Local Treatment Compared to Second-line Treatment in Patients With BRAFV600+ Metastatic Melanoma in Focal Progression With First-line+Vemurafenib+Cobimetinib.treatment2unknown_status
NCT05727904
Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.treatment3recruiting
NCT01005472
Temozolomide and Sunitinib Malate in Treating Patients With Stage III or Stage IV Malignant Melanomatreatment1completed
NCT03724968
Nivolumab Plus Relatlimab or Ipilimumab in Metastatic Melanoma Stratified by MHC-II Expressiontreatment2terminated
NCT02858869
Pembrolizumab and Stereotactic Radiosurgery for Melanoma or Non-Small Cell Lung Cancer Brain Metastasestreatment1completed
NCT01590069
Aerosolized Aldesleukin in Treating Patients With Lung Metastasestreatment1active_not_recruiting
NCT05304546
Overcoming Primary Resistance to Immunotherapy in Metastatic Melanomatreatment2not_yet_recruiting
NCT05954546
A Study to Compare How Effective is Encorafenib Plus Binimetinib in Real-world and Clinical Trial SettingsNo drug interventionsNot AvailableNot Availablecompleted
NCT04759846
Hepatic Impairment Study of Encorafenib in Combination With Binimetinib in BRAF Melanomatreatment1withdrawn
NCT04588246
Testing the Addition of Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to Stereotactic Radiosurgery in People With Cancer That Has Spread to the Brain and Come Back in Other Areas of the Brain After Earlier Stereotactic Radiosurgerytreatment3recruiting
NCT03865212
Modified Virus VSV-IFNbetaTYRP1 in Treating Patients With Stage III-IV Melanomatreatment1active_not_recruiting
NCT01876212
Dendritic Cell Vaccines + Dasatinib for Metastatic Melanomatreatment2completed
NCT00668512
Intratumoral Injection Of Alpha-Gal GlycosphingolipidsNot Available1completed
NCT02177110
A Translational Systems Medicine Approach to Provide Predictive Capacity for Therapy Response in Advanced or Metastatic Malignant MelanomaNo drug interventionsNot AvailableNot Availablecompleted
NCT01273181
MAGE-A3/12 Metastatic Cancer Treatment With Anti-MAGE-A3/12 TCR-Gene Engineered Lymphocytestreatment1 / 2terminated
NCT02379195
Peginterferon and TIL Therapy for Metastatic Melanomatreatment1 / 2completed
NCT05607095
Pilot Trial of Autologous Tumor Infiltrating Lymphocytes (LN-144) for Patients With Metastatic Uveal Melanomatreatment1recruiting
NCT03879395
Surgery for Gastrointestinal Metastases of Malignant Melanoma - a Single Center Retrospective Cohort StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT01134250
Combination Therapy of F16IL2 and Paclitaxel in Solid Tumour Patientstreatment1 / 2completed
NCT00910650
Study of Gene Modified Immune Cells in Patients With Advanced Melanomatreatment2completed
NCT02306850
Neoadjuvant Pembrolizumab for Unresectable Stage III and Unresectable Stage IV Melanomatreatment2completed
NCT02414750
Vemurafenib Plus Cobimetinib in Metastatic Melanomaother2terminated
NCT05779423
Cryoablation+Ipilimumab+Nivolumab in Melanomatreatment2recruiting
NCT01119508
Ipilimumab + Temozolomide in Metastatic Melanomatreatment2completed
NCT01425008
Study of MLN2480 in Participants With Relapsed or Refractory Solid Tumors Followed by a Dose Expansion in Participants With Metastatic Melanomatreatment1completed
NCT06066138
A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosingtreatment1not_yet_recruiting
NCT06469138
A Phase 1 Study to Investigate 14C-bemcentinib Following Single Oral Administration in Healthy Male Subjectstreatment1completed
NCT00597038
A Phase I/II Study of Dasatinib and Dacarbazinetreatment1 / 2completed
NCT02862743
Molecular Characterization of Advanced Stage Melanoma by Blood SamplingNo drug interventionsbasic_scienceNot Availablecompleted
NCT02354690
Vemurafenib and TIL Therapy for Metastatic Melanomatreatment1 / 2completed
NCT04899921
Troriluzole or Placebo Plus Ipi Plus Nivo in Mel Brain Metstreatment2terminated
NCT03674502
Safety of ADU-1604 in Adults With Metastatic MelanomaNo drug interventionstreatment1terminated
NCT04514484
Testing the Combination of the Anti-cancer Drugs XL184 (Cabozantinib) and Nivolumab in Patients With Advanced Cancer and HIVtreatment1active_not_recruiting
NCT02375984
A Study Using Tumor-Reactive Autologous Tumor Infiltrating Lymphocytes (TIL) in Metastatic MelanomasNo drug interventionstreatment2terminated
NCT02126579
Phase I/II Trial of a Long Peptide Vaccine (LPV7) Plus TLR AgonistsNo drug interventionstreatment1 / 2completed
NCT04478279
A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumorstreatment1 / 2active_not_recruiting
NCT02360579
Study of Lifileucel (LN-144), Autologous Tumor Infiltrating Lymphocytes, in the Treatment of Patients With Metastatic Melanomatreatment2active_not_recruiting
NCT03875079
A Study To Evaluate Safety And Therapeutic Activity Of RO6874281 In Combination With Pembrolizumab, In Participants With Advanced Or Metastatic Melanomatreatment1completed
NCT00203879
Study of MAGE-3/Melan-A/gp 100/NA17 and rhIL-12 With/Out Low Dose IL-2 in Metastatic Melanomatreatment2completed
NCT02713269
Thermal Ablation and Spine Stereotactic Radiosurgery in Treating Patients With Spine Metastases at Risk for Compressing the Spinal CordNo drug interventionstreatment2active_not_recruiting
NCT03873818
Low Dose Ipilimumab With Pembrolizumab in Treating Patients With Melanoma That Has Spread to the Braintreatment2active_not_recruiting
NCT04140500
Dose Escalation Study of a PD1-LAG3 Bispecific Antibody in Patients With Advanced and/or Metastatic Solid Tumorstreatment1 / 2recruiting
NCT03708328
A Dose Escalation and Expansion Study of Lomvastomig, a PD-1/TIM-3 Bispecific Antibody, in Participants With Advanced and/or Metastatic Solid Tumorstreatment1completed
NCT05704933
Pilot Study of Nivolumab w/Ipilimumab or Relatlimab in Surgically Resectable Melanoma Brain Metastasestreatment0active_not_recruiting
NCT01416831
Comparison of High-dose IL-2 and High-dose IL-2 With Radiation Therapy in Patients With Metastatic Melanoma.treatment2active_not_recruiting
NCT01644591
Stereotactic Radiosurgery in Treating Patients With Greater Than 3 Melanoma Brain MetastasesNo drug interventionstreatment2active_not_recruiting
NCT04007744
Sonidegib and Pembrolizumab in Treating Patients With Advanced Solid Tumorstreatment1recruiting
NCT05655312
MC1R-targeted Alpha-particle Therapy Trial in Adults With Advanced MelanomaNo drug interventionstreatment1 / 2recruiting
NCT05786924
A Study of BDTX-4933 in Patients With KRAS, BRAF and Select RAS/MAPK Mutation-Positive CancersNo drug interventionstreatment1recruiting
NCT06549439
eFLASH for Skin Lesions of Malignant MelanomasNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT01134614
Ipilimumab With or Without Sargramostim in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed by Surgerytreatment2active_not_recruiting
NCT01319565
Prospective Randomized Study of Cell Transfer Therapy for Metastatic Melanoma Using Tumor Infiltrating Lymphocytes Plus IL-2 Following Non-Myeloablative Lymphocyte Depleting Chemo Regimen Alone or in Conjunction With 12Gy Total Body Irradiation (TBI...treatment2active_not_recruiting
NCT02224781
Dabrafenib and Trametinib Followed by Ipilimumab and Nivolumab or Ipilimumab and Nivolumab Followed by Dabrafenib and Trametinib in Treating Patients With Stage III-IV BRAFV600 Melanomatreatment3active_not_recruiting
NCT04129515
NovoTTF-200A + Pembrolizumab In Melanoma Brain Metastasistreatment1 / 2not_yet_recruiting
NCT04511013
A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastasestreatment2recruiting
NCT04695977
CMP-001 in Combination With Nivolumab Compared to Nivolumab Monotherapy in Subjects With Advanced Melanomatreatment2 / 3completed
NCT05155033
Phase II Trial of Combination Anti-PD-1 and Aldesleukin for Metastatic Melanoma and Renal Cell Carcinomatreatment2recruiting
NCT05629546
Memory-Like Natural Killer Cells With Nivolumab and Relatlimab in Advanced or Metastatic Melanoma After Progression on Checkpoint Inhibitorstreatment1not_yet_recruiting
NCT01005745
Lymphodepletion Plus Adoptive Cell Transfer With High Dose IL-2 in Patients With Metastatic MelanomatreatmentNot Availableactive_not_recruiting
NCT03276832
Imiquimod and Pembrolizumab in Treating Patients With Stage IIIB-IV Melanomatreatment0active_not_recruiting
NCT05470283
Phase I, Open-Label, Study of Tumor Infiltrating Lymphocytes Engineered With Membrane Bound IL15 Plus Acetazolamide in Adult Patients With Metastatic Melanomatreatment1active_not_recruiting
NCT01902173
Uprosertib, Dabrafenib, and Trametinib in Treating Patients With Stage IIIC-IV Cancertreatment1 / 2active_not_recruiting
NCT02581930
Ibrutinib in Treating Patients With Refractory Metastatic Cutaneous Melanomatreatment2active_not_recruiting
NCT03816332
Tacrolimus, Nivolumab, and Ipilimumab in Treating Kidney Transplant Recipients With Selected Unresectable or Metastatic Cancerstreatment1active_not_recruiting
NCT05026983
Binimetinib and Encorafenib for the Treatment of Metastatic Melanoma and Central Nervous System Metastasestreatment2recruiting
NCT06500455
Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the BrainNo drug interventionstreatment3not_yet_recruiting
NCT03131908
Study of the Selective PI3K-Beta Inhibitor GSK2636771 in Combination With Pembrolizumab in Patients With Metastatic Melanoma and PTEN Losstreatment1 / 2active_not_recruiting
NCT04272658
PET/CT Whole-body Dynamic Acquisition at FDG to Metastatic Melanoma Under ImmunotherapyNo drug interventionsNot AvailableNot Availablerecruiting
NCT04903119
Nilotinib Plus Dabrafenib/Trametinib in Metastatic Melanomatreatment1recruiting
NCT04955743
Pembrolizumab and Lenvatinib in Patients With Brain Metastases From Melanoma or Renal Cell Carcinomatreatment2recruiting
NCT05640193
A Study of LN-144 in People With Metastatic Melanoma to the Braintreatment1active_not_recruiting
NCT06488365
In Vivo Liquid Biopsy of Melanoma (Cytophone)No drug interventionsdiagnosticNot Availablenot_yet_recruiting
NCT05628883
Proof of Concept of TBio-4101, Lymphodepleting Chemo, IL-2 for Relapsed/Refractory Melanomatreatment1recruiting
NCT01659151
Vemurafenib With Lymphodepletion Plus Adoptive Cell Transfer & High Dose IL-2 Metastatic Melanomatreatment2active_not_recruiting
NCT02650986
Gene-Modified T Cells With or Without Decitabine in Treating Patients With Advanced Malignancies Expressing NY-ESO-1treatment1 / 2active_not_recruiting
NCT02700971
RATIO: Rational Approach To Immuno-OncologyNo drug interventionsbasic_scienceNot Availablecompleted
NCT04557956
Testing the Addition of the Anti-cancer Drug, Tazemetostat, to the Usual Treatment (Dabrafenib and Trametinib) for Metastatic Melanoma That Has Progressed on the Usual Treatmenttreatment1 / 2recruiting
NCT05269381
Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumorstreatment1 / 2recruiting
NCT05764395
Rigosertib Plus Pembrolizumab in Treating Patients With Unresectable/Metastatic Melanoma Refractory to PD-1 Inhibitorstreatment2recruiting
NCT05856565
Generation of an Artificial Intelligence Algorithm Based on the Analysis of Melanoma Peri-scar Dermatoheliosis, as a Predictive Factor of Response to Anti-PD-1No drug interventionsNot AvailableNot Availablerecruiting
NCT02298959
Testing the PD-1 Antibody, MK3475, Given With Ziv-aflibercept in Patients With Advanced Cancertreatment1active_not_recruiting
NCT02910700
Nivolumab With Trametinib and Dabrafenib, or Encorafenib and Binimetinib in Treating Patients With BRAF Mutated Metastatic or Unresectable Stage III-IV Melanomatreatment2active_not_recruiting
NCT02631447
Sequential Combo Immuno and Target Therapy (SECOMBIT) Studytreatment2completed
NCT03817125
Melanoma Checkpoint and Gut Microbiome Alteration With Microbiome Interventiontreatment1completed
NCT06060613
Safety and Efficacy of OBX-115 in Advanced Solid Tumorstreatment1 / 2recruiting
NCT04119024
Gene Modified Immune Cells (IL13Ralpha2 CAR T Cells) After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumorstreatment1recruiting
NCT05034536
PD-1 Antibody Therapy + Infliximab for Metastatic Melanomatreatment2recruiting
NCT05169957
Hepatic Ablation of Melanoma Metastases to Enhance Immunotherapy Response, a Phase I Clinical Trial (HAMMER I)treatment1active_not_recruiting
NCT02419495
Phase IB Study to Evaluate the Safety of Selinexor (KPT-330) in Combination With Multiple Standard Chemotherapy or Immunotherapy Agents in Patients With Advanced Malignanciestreatment1active_not_recruiting
NCT03175432
Bevacizumab and Atezolizumab With or Without Cobimetinib in Treating Patients With Untreated Melanoma Brain Metastasestreatment2active_not_recruiting
NCT01989585
Testing the Addition of Navitoclax to the Combination of Dabrafenib and Trametinib in People Who Have BRAF Mutant Melanomatreatment1 / 2active_not_recruiting
NCT04140526
Safety, PK and Efficacy of ONC-392 in Monotherapy and in Combination of Anti-PD-1 in Advanced Solid Tumors and NSCLCtreatment1 / 2recruiting
NCT04940299
Tocilizumab, Ipilimumab, and Nivolumab for the Treatment of Advanced Melanoma, Non-Small Cell Lung Cancer, or Urothelial Carcinomatreatment2active_not_recruiting
NCT02027935
CD8+ Antigen-Specific T Cells, Cyclophosphamide, Aldesleukin, and Ipilimumab in Treating Patients With Metastatic Melanomatreatment2completed
NCT04693377
Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME TrialNo drug interventionssupportive_careNot Availablerecruiting
NCT03122522
A Study to Evaluate Adaptive Dosing of Ipilimumab and Nivolumab Combination Immunotherapytreatment2active_not_recruiting
NCT01621490
PH 1 Biomarker Study of Nivolumab and Ipilimumab and Nivolumab in Combination With Ipilimumab in Advanced Melanomabasic_science1completed
NCT05341349
Stereotactic Radiosurgery and Immune Checkpoint Inhibitors With NovoTTF-100M for the Treatment of Melanoma Brain Metastasestreatment1recruiting
NCT01955460
Genetically Modified T-Cells Followed by Aldesleukin in Treating Patients With Stage III-IV Melanomatreatment1active_not_recruiting
NCT04771520
Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid Tumorstreatment2recruiting
NCT06369428
Patient Characteristics, Treatment Patterns, and Healthcare Resource Utilization of Metastatic Melanoma PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT03025256
Intravenous and Intrathecal Nivolumab in Treating Patients With Leptomeningeal Diseasetreatment1active_not_recruiting
NCT03625141
A Study Evaluating the Safety and Efficacy of Cobimetinib Plus Atezolizumab in BRAFV600 Wild-type Melanoma With Central Nervous System Metastases and Cobimetinib Plus Atezolizumab and Vemurafenib in BRAFV600 Mutation-positive Melanoma With Central Nervous System Metastasestreatment2completed
NCT03645928
Study of Autologous Tumor Infiltrating Lymphocytes in Patients With Solid Tumorstreatment2recruiting
NCT04625205
NEO-PTC-01 in Patients With Advanced or Metastatic MelanomaNo drug interventionstreatment1recruiting
NCT05913388
GB1211 and Pembrolizumab Versus Pembrolizumab and Placebo in Patients With Metastatic Melanoma and Head and Neck Squamous Cell Carcinomatreatment2recruiting
NCT02816021
Study of Oral Azacitidine (CC-486) in Combination With Pembrolizumab (MK-3475) in Patients With Metastatic Melanomatreatment2active_not_recruiting
NCT03590054
Abexinostat in Combination With Pembrolizumab in Patients With Advanced Solid Tumor Malignanciestreatment1completed
NCT04930783
NeoVax + CDX-301 and Nivolumab or Pembrolizumab in Melanomatreatment1recruiting
NCT05388877
E6201 and Dabrafenib for the Treatment of Central Nervous System Metastases From BRAF V600 Mutated Metastatic Melanomatreatment1recruiting
NCT05695898
XmAb23104 (PD1 X ICOS) and XmAb22841 (CTLA-4 X LAG3) in Treating Melanoma Prior Immune Checkpoint Inhibitor Therapytreatment1active_not_recruiting
NCT01738139
Ipilimumab and Imatinib Mesylate in Advanced Cancertreatment1completed
NCT01364051
Cediranib Maleate and Selumetinib Sulfate in Treating Patients With Solid Malignanciestreatment1active_not_recruiting
NCT02678741
Multi-center Phase I/IIa Trial of an Autologous Tumor Lysate (TL) + Yeast Cell Wall Particles (YCWP) + Dendritic Cells (DC) Vaccine in Addition to Standard of Care Checkpoint Inhibitor of Choice in Metastatic Melanoma Patients With Measurable Disease.No drug interventionstreatment1 / 2completed
NCT06151847
Lifileucel With Reduced Dose Fludarabine/Cyclophosphamide Lymphodepletion and Interleukin-2 for the Treatment of Patients With Unresectable or Metastatic Melanomatreatment2recruiting
NCT04698187
CMP-001 in Combination With Nivolumab in Subjects With Advanced Melanomatreatment2completed
NCT03475134
TIL-ACT After NMA Chemo With IL-2 and Nivo Rescue in Metastatic Melanoma (mMEL)treatment1active_not_recruiting
NCT05578872
A Study of ANV419 Alone or in Combination With Approved Treatment in Patients With Cutaneous Melanoma (OMNIA-1).treatment1 / 2recruiting
NCT06180460
CALM: Managing Distress in Malignant Brain CancerNo drug interventionssupportive_careNot Availablerecruiting
NCT04242329
Surgery of Melanoma Metastases After Systemic TherapyNo drug interventionstreatment2withdrawn
NCT03888950
Interim FDG PET-CT in Melanoma Metastatic Patient's Treated by Anti-PD1 TherapyNo drug interventionsotherNot Availablerecruiting
NCT03646617
Ipilumumab and Nivolumab With or Without Hypofractionated Radiotherapy in Patients With Metastatic Melanomatreatment2recruiting
NCT04109456
IN10018 Monotherapy and Combination Therapy for Metastatic Melanomatreatment1recruiting
NCT04967196
Ipilimumab and Nivolumab for the Treatment of Stage III-IV Unresectable Metastatic Melanomatreatment1active_not_recruiting
NCT05155254
IO102-IO103 in Combination With Pembrolizumab Versus Pembrolizumab Alone in Advanced Melanoma (IOB-013 / KN-D18)treatment3active_not_recruiting
NCT03123783
CD40 Agonistic Antibody APX005M (Sotigalimab) in Combination With Nivolumabtreatment1 / 2completed
NCT05393713
Intra-Lymphatic STI-3031 Using the Sofusa DoseConnect Device for Treatment of In-Transit Melanoma, The Sofusa-2 Studytreatment1active_not_recruiting
NCT04789668
Bintrafusp Alfa and Pimasertib for the Treatment of Patients With Brain Metastasestreatment1 / 2completed
NCT01856023
HD IL-2 + Ipilimumab in Patients With Metastatic Melanomatreatment4terminated
NCT03229278
Trigriluzole With Nivolumab and Pembrolizumab in Treating Patients With Metastatic or Unresectable Solid Malignancies or Lymphomatreatment1completed
NCT02278887
Study Comparing TIL to Standard Ipilimumab in Patients With Metastatic Melanomatreatment3active_not_recruiting
NCT04793737
Precision Radiation of Immune Checkpoint Therapy Resistant Melanoma MetastasesNo drug interventionstreatmentNot Availablerecruiting
NCT02304458
Nivolumab With or Without Ipilimumab in Treating Younger Patients With Recurrent or Refractory Solid Tumors or Sarcomastreatment1 / 2completed
NCT06075524
Evaluation of Anti-PD-1 Therapy by Monitoring T Cell Responses in Melanoma, Lung and Other Cancer TypesNo drug interventionsNot AvailableNot Availablerecruiting
NCT02310451
Study of Molecular Mechanisms Implicated in the Pathogenesis of Melanoma. Role of ExosomesNo drug interventionsscreeningNot Availablecompleted
NCT03430297
A Randomized, Controlled, Multi-center, Phase III Clinical Study to Investigate Recombinant Humanized PD-1 Monoclonal Antibody Injection (JS001) Versus Dacarbazine as the 1st-line Therapy for Unresectable or Metastatic Melanomatreatment3active_not_recruiting
NCT02748564
Aldesleukin and Pembrolizumab in Treating Patients With Stage III-IV Melanomatreatment2terminated
NCT03679767
A Study of INCMGA00012 in Participants With Selected Solid Tumors (POD1UM-203)treatment2completed
NCT03803397
Arm 1: Lysate Pulsed Dendritic Cells (PV-001-DC) in Patients With MelanomaNo drug interventionstreatment1not_yet_recruiting
NCT03898908
Encorafenib and Binimetinib Before Local Treatment in Patients With BRAF Mutant Melanoma Metastatic to the Braintreatment2active_not_recruiting
NCT03864042
Pharmacokinetic Drug-drug Interaction Study of Encorafenib and Binimetinib on Probe Drugs in Patients With BRAF V600-mutant Melanoma or Other Advanced Solid Tumorstreatment1active_not_recruiting
NCT04987996
GR-MD-02 + Pembrolizumab Versus Pembrolizumab Monotherapy in Melanoma and Squamous Cell Head and Neck Cancer Patientstreatment2withdrawn
NCT05878977
Biomarkers in Immunotherapy of MelanomaNo drug interventionstreatmentNot Availablerecruiting
NCT05848219
Healthcare Resource Utilization and Costs in Metastatic Melanoma Patients Initiated Dabrafenib + Trametinib and Encorafenib + BinimetinibNo drug interventionsNot AvailableNot Availableterminated
NCT02141542
Phase I Clinical Trial of Tremelimumab Plus MEDI3617 in Patients With Unresectable Stage III or Stage IV Melanomatreatment1completed
NCT01995344
TIL Therapy in Metastatic Melanoma and IL2 Dose Assessmenttreatment2terminated
NCT03474497
UCDCC#272: IL-2, Radiotherapy, and Pembrolizumab in Patients Refractory to Checkpoint Blockadetreatment1 / 2recruiting
NCT03743298
Safety of AV-MEL-1 With Anti-PD-1 Therapy in Metastatic MelanomaNo drug interventionstreatment1recruiting
NCT04960059
NOTION: iN-home Sampling Of cyTokines in ImmunOtherapy patieNtsNo drug interventionsNot AvailableNot Availablerecruiting
NCT02500576
Pembrolizumab, Standard Chemotherapy, Tumor Infiltrating Lymphocytes, and High- or Low-Dose Aldesleukin in Treating Patients With Metastatic Melanomatreatment2completed
NCT05750511
Multicenter Tissue Registry in MelanomaNo drug interventionsNot AvailableNot Availablerecruiting
NCT03265080
A Study of ADXS-NEO Expressing Personalized Tumor Antigenstreatment1terminated
NCT03913923
Study of Efficacy and Safety of BCD-217 (Anti-CTLA-4 and Anti-PD-1) Followed By BCD-100 (Anti-PD-1) Versus BCD-100 Monotherapy as First-Line Treatment in Patients With Unresectable or Metastatic MelanomaNo drug interventionstreatment2active_not_recruiting
NCT05732805
A Clinical Study of BCD-217 (Nurulimab + Prolgolimab) Followed by Anti-PD-1 Compared to Anti-PD-1 Monotherapy as First-Line Treatment in Subjects With Unresectable/Metastatic Melanomatreatment3recruiting
NCT01993719
Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Melanomatreatment2completed
NCT05588453
Natural Killer Cell Therapy (UD TGFbetai NK Cells) and Temozolomide for the Treatment of Stage IV Melanoma Metastatic to the Braintreatment1 / 2recruiting
NCT05641012
Association Between Helioderma and Response to Immunotherapy in Patients With Metastatic MelanomaNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT04941365
Quantifying Systemic Immunosuppression to Personalize Cancer TherapyNo drug interventionsdiagnosticNot Availablewithdrawn
NCT04911998
A Prospective Observational Study on Targeted Therapy for Unresectable or Metastatic BRAFV600E Mutant Melanoma PatientsNo drug interventionsNot AvailableNot Availablerecruiting
NCT04698161
Establishment of the Human Intestinal and Salivary Microbiota Biobank - Oncologic DiseasesNo drug interventionsNot AvailableNot Availablecompleted
NCT04633902
Phase II Study of Olaparib and Pembrolizumab in Advanced Melanoma With Homologous Recombination (HR) Mutationtreatment2recruiting
NCT04158544
Immune Monitoring in Metastatic MelanomaNo drug interventionsNot AvailableNot Availableunknown_status
NCT04060407
CD24Fc With Ipilimumab and Nivolumab to Decrease irAE (CINDI)treatment1 / 2withdrawn
NCT04042506
SBRT as a Vaccination for Metastatic Melanomatreatment2withdrawn
NCT04021420
Safety and Efficacy of Sonocloud Device Combined With Nivolumab in Brain Metastases From Patients With Melanomatreatment1 / 2recruiting
NCT03991741
Adoptive Cell Transfer of Autologous Tumor Infiltrating Lymphocytes and High-Dose Interleukin 2 in Select Solid Tumorstreatment1recruiting
NCT03925350
Efficacy and Safety Study of Niraparib in Melanoma With Genetic Homologous Recombination (HR) Mutationtreatment2recruiting
NCT03773744
MG1-MAGEA3 With Ad-MAGEA3 and Pembrolizumab in Patients With Previously Treated Metastatic Melanoma or Cutaneous Squamous Cell Carcinomatreatment1withdrawn
NCT03728465
Evaluation of Safety and Efficacy of Patients With Four and More Symptomatic Brain Metastases of Melanomatreatment2terminated
NCT03526185
A Pilot Study Using Short-Term Cultured Anti-Tumor Autologous Lymphocytestreatment0terminated
NCT03445533
A Study of Tilsotolimod in Combo With Ipilimumab vs Ipilimumab Alone in Subjects With Anti-PD-1 Refractory Melanomatreatment3terminated
NCT03425461
Anti-SEMA4D Monoclonal Antibody VX15/2503 With Nivolumab or Ipilimumab in Treating Patients With Stage III or IV Melanomatreatment1terminated
NCT03326258
Glembatumumab Vedotin, Nivolumab, and Ipilimumab in Treating Patients With Advanced Metastatic Solid Tumors That Cannot Be Removed by Surgerytreatment1 / 2withdrawn
NCT03297463
Radiation Therapy With Combination Immunotherapy for Relapsed/Refractory Metastatic Melanomatreatment1 / 2withdrawn
NCT03225365
Nivolumab +/- Ipilimumab Immunomonitoring in Metastatic MelanomaNo drug interventionsotherNot Availablecompleted
NCT03176485
Evaluation of Pathway Modulation by Raf, MEK, & Kinase InhibitorsNo drug interventionspreventionNot Availablecompleted
NCT03155217
Tolerance of Targeted Therapy Used in Metastatic Melanoma in Patients Aged Over 65 and 75-year-oldNo drug interventionsNot AvailableNot Availablecompleted
NCT03126461
SAbR Plus Ipilimumab Plus Nivolumab in Metastatic Melanoma Patientstreatment2withdrawn
NCT03073473
Evaluation of the NantHealth GPS Cancer Test in Patients With Advanced CancersNo drug interventionsNot AvailableNot Availableterminated
NCT03047928
Combination Therapy With Nivolumab and PD-L1/IDO Peptide Vaccine to Patients With Metastatic Melanomatreatment1 / 2recruiting
NCT02857270
A Study of LY3214996 Administered Alone or in Combination With Other Agents in Participants With Advanced/Metastatic Cancertreatment1completed
NCT02768207
A Study to Detect V-Raf Murine Sarcoma Viral Oncogene Homolog B1 (BRAF) V600 Mutation on Cell-Free Deoxyribonucleic Acid (cfDNA) From Plasma in Participants With Advanced Melanomascreening2completed
NCT02755233
Ipilimumab-induced Lung Toxicity: Observational StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT02644967
A Phase 2 Study to Assess the Safety and Efficacy of IMO-2125 With 8 mg Ipilimumab in Patients With Metastatic Melanomatreatment2completed
NCT02625337
Study Comparing Pembrolizumab With Dual MAPK Pathway Inhibition Plus Pembrolizumab in Melanoma Patientstreatment2unknown_status
NCT02608437
A Study Investigating SGI-110 in Combination With Ipilimumab in Unresectable or Metastatic Melanoma Patientstreatment1unknown_status
NCT02521870
A Trial of Intratumoral Injections of SD-101 in Combination With Pembrolizumab in Patients With Metastatic Melanoma or Recurrent or Metastatic Head and Neck Squamous Cell Carcinomatreatment1 / 2terminated
NCT02424916
Adoptive Transfer of Specific Melanoma Antigens CD8+ T Cells in Metastatic Melanoma Patients: a Phase I/II StudyNo drug interventionstreatment1 / 2completed
NCT02392871
Radiotherapy & Combi in Metastatic Melanomatreatment1 / 2completed
NCT02357732
Study of the Anti-PD-1 Antibody Nivolumab in Combination With Dabrafenib and/or Trametinibtreatment1withdrawn
NCT02150369
Interleukin-2-Induced Cognitive/Affective/Sleep SymptomsNo drug interventionsNot AvailableNot Availablecompleted
NCT02142335
Rituxan and Abraxane for the Treatment of Patients With Inoperable Stage III and IV Malignant Melanomatreatment2unknown_status
NCT02097732
Ipilimumab Induction in Patients With Melanoma Brain Metastases Receiving Stereotactic Radiosurgerytreatment2terminated
NCT02097225
Onalespib, Dabrafenib, and Trametinib in Treating Patients With BRAF-Mutant Melanoma or Solid Tumors That Are Metastatic or Cannot Be Removed by Surgerytreatment1active_not_recruiting
NCT02073123
Study of IDO Inhibitor in Combination With Checkpoint Inhibitors for Adult Patients With Metastatic Melanomatreatment1 / 2completed
NCT02062359
T Cell Receptor Immunotherapy Targeting NY-ESO-1 for Patients With NY-ESO-1 Expressing Melanomatreatment2terminated
NCT02009397
A Phase I/II Open-Label Study of Ipilimumab and GM-CSF Administered to Unresectable Stage IIIC and Stage IV Melanoma Patientstreatment1 / 2completed
NCT02009384
Ipilimumab Administered to Stage IIIC Stage IV Melanoma After Reg. T Cell Depletion With Denileukin Diftitoxtreatment2terminated
NCT01940809
Ipilimumab With or Without Dabrafenib, Trametinib, and/or Nivolumab in Treating Patients With Melanoma That Is Metastatic or Cannot Be Removed by Surgerytreatment1terminated
NCT01933061
Study to Determine Efficacy and Safety of CC-486 With Nab-Paclitaxel Versus Nab-Paclitaxel in Patients With Chemotherapy naïve Metastatic Melanomatreatment2withdrawn
NCT01927419
Study of Nivolumab (BMS-936558) Plus Ipilimumab Compared With Ipilimumab Alone in the Treatment of Previously Untreated, Unresectable, or Metastatic Melanomatreatment2completed
NCT01920516
Isolated Limb Perfusion of Melphalan for Melanoma and Sarcoma TreatmentNot AvailableNot Availableunknown_status
NCT01904123
STAT3 Inhibitor WP1066 in Treating Patients With Recurrent Malignant Glioma or Progressive Metastatic Melanoma in the Braintreatment1completed
NCT01878396
Circulating Melanoma Cells in Metastatic Patients Treated With Selective BRAF InhibitorsNo drug interventionsNot AvailableNot Availableunknown_status
NCT01876641
Treatment of a Resistant Disease Using Decitabine Combined With Vemurafenib Plus Cobimetinibtreatment1terminated
NCT01864538
A Phase 2 Biomarker - Enriched Study of TH-302 in Subjects With Advanced Melanomatreatment2terminated
NCT01838200
Phase I Study of Intralesional Bacillus Calmette-Guerin (BCG) Followed by Ipilimumab in Advanced Metastatic Melanomatreatment1terminated
NCT01807182
Tumor-Infiltrating Lymphocytes After Combination Chemotherapy in Treating Patients With Metastatic Melanomatreatment2completed
NCT01743157
Biochemotherapy and Bevacizumab Followed by Consolidation Therapy With Ipilimumab for Metastatic Melanomatreatment1 / 2completed
NCT01723813
Peptide Vaccinations Plus GM-CT-01 in Melanomatreatment1 / 2terminated
NCT01702896
Interleukin-2 in Metastatic Melanomatreatment2terminated
NCT01689870
Study of the Combination of Anti-OX40 and Ipilimumab in Patients With Metastatic Melanomatreatment1 / 2withdrawn
NCT01683188
HD IL-2 + Vemurafenib in Patients With BRAF Mutation Positive Metastatic Melanomaother4terminated
NCT01620749
Of 18F MEL050 Using PET/CT in Metastatic MelanomaNo drug interventionsdiagnostic0unknown_status
NCT01558349
Circulating Tumor Cells and Melanoma: Comparing the EPISPOT and CellSearch TechniquesNo drug interventionsNot AvailableNot Availablecompleted
NCT01542255
Metronomic Therapy in Patients With Metastatic Melanomatreatment2terminated
NCT01497808
RADVAX™: A STRATIFIED PHASE I/II DOSE ESCALATION TRIAL OF HYPOFRACTIONATED RADIOTHERAPY FOLLOWED BY IPILIMUMAB IN METASTATIC MELANOMAtreatment1 / 2completed
NCT01495988
Trial of Vemurafenib/Cobimetinib With or Without Bevacizumab in Patients With Stage IV BRAFV600 Mutant Melanomatreatment2terminated
NCT01495572
Melanoma Treatment With White Blood Cells That Destroy MART Expressing Tumor Cellstreatment2terminated
NCT01468818
Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Melanomatreatment2terminated
NCT01457131
Modified White Blood Cells That Secrete IL-2 and Express a Protein That Targets the ESO-1tumor Protein for Metastatic Cancertreatment1terminated
NCT01416844
Study of Immune Responses in Patients With Metastatic MelanomaNo drug interventionstreatment2withdrawn
NCT01415167
PROCLAIM Registry to Evaluate the Treatment Patterns and Clinical Response in MalignancyNo drug interventionsNot AvailableNot Availablecompleted
NCT01369888
Use of IL-15 After Chemotherapy and Lymphocyte Transfer in Metastatic Melanomatreatment1 / 2terminated
NCT01369875
Modified Tumor Infiltrating Lymphocytes for Metastatic Melanomatreatment2terminated
NCT01340729
Open-Label Study of TPI 287 for Patients With Metastatic Melanomatreatment1 / 2withdrawn
NCT01335009
Efficacy Study of Pharmacokinetic(PK)/Pharmacodynamic(PD) Relationship of Monotherapy MORAb-004 in Metastatic Melanomatreatment2completed
NCT01312506
Collection of Cerebrospinal Fluid and Tumor Tissue in Subjects With Metastatic Melanoma and ControlsNo drug interventionsNot AvailableNot Availablewithdrawn
NCT01258855
Aldesleukin With or Without Ziv-Aflibercept in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed by Surgerytreatment2completed
NCT01218867
CAR T Cell Receptor Immunotherapy Targeting VEGFR2 for Patients With Metastatic Cancertreatment1 / 2terminated
NCT01216436
Local Modulation of Immune Receptors to Enhance the Response to Dendritic Cell Vaccination in Metastatic MelanomaNo drug interventionsNot Available1terminated
NCT01216696
Ipilimumab in Patients With Advanced Melanoma and Spontaneous Preexisting Immune Response to NY-ESO-1treatment2completed
NCT01212276
A Safety and MORAb-028 Dose Determination Study in Subjects With Metastatic MelanomaNo drug interventionstreatment1terminated
NCT01191034
Peptide Vaccination Associated With Tumoral Immunomodulation in Patients With Advanced Metastatic Melanomatreatment1 / 2terminated
NCT01160445
Phase II Study of Aldesleukin (IL-2) Following the Administration of Zanolimumab (Anti-CD4mAb) in Metastatic Melanoma and Metastatic Renal Cancertreatment2terminated
NCT01118091
Prospective Randomized Comparative Study of Cell Transfer Therapy Using CD8+-Enriched Short-Term Cultured Anti-Tumor Autologous Lymphocytes Following a Non-Myeloablative Lymphocyte Depleting Chemotherapy Regimen Compared to High-Dose Aldesleukin in M...treatment2completed
NCT01082887
A Study of Immunotherapy With TIL (Tumor Infiltrating Lymphocytes) in Combination With Intra-tumoral Injections of Interferon Gamma-adenovirus (Ad-IFNg) in Patients With Stage IIIc or Stage IV Metastatic Melanoma (AJCC)(Protocol TIL-Ad-INFg)No drug interventionstreatment1 / 2terminated
NCT01014351
Study of Everolimus With Paclitaxel and Carboplatin in Patients With Metastatic Melanomatreatment2completed
NCT01011530
Dose Escalation Study of MLN4924 in Adults With Melanomatreatment1completed
NCT00986661
A Study to Assess PV-10 Chemoablation of Cancer of the Livertreatment1active_not_recruiting
NCT00984464
Study of REOLYSIN® in Combination With Paclitaxel and Carboplatin in Patients With Metastatic Melanomatreatment2completed
NCT00948480
Vaccine Biotherapy of Cancer: Autologous Tumor Cells and Dendritic Cellstreatment2completed
NCT00928031
Long-term Data Collection for Subjects in MDX-010 StudiesNo drug interventionsNot AvailableNot Availablecompleted
NCT00925132
Treatment of Resistant Metastatic Melanoma Using Decitabine, Temozolomide and Panobinostattreatment1 / 2terminated
NCT00881049
Trial of Imatinib (Gleevec®) in Selected Patients With Metastatic Melanomatreatment2completed
NCT00804908
A Study Evaluating Efficacy of ABT-888 in Combination With Temozolomide in Metastatic Melanomatreatment2completed
NCT00758797
A Novel Treatment for Metastatic MelanomaNo drug interventionstreatment1terminated
NCT00734188
Dose Escalation and Safety Study of 188Re-PTI-6D2 in Patients With Metastatic MelanomaNo drug interventionstreatment1completed
NCT00733798
A Safety and Efficacy Study of Intravenous 131I-TM601 in Adult Patients With Malignant Melanomatreatment1 / 2terminated
NCT00724841
A Phase I/II Study of GMX1777 in Combination With Temozolomide for the Treatment of Metastatic Melanomatreatment1 / 2terminated
NCT00672542
Immunotherapy of Melanoma With Tumor Antigen RNA and Small Inhibitory RNA Transfected Autologous Dendritic CellsNo drug interventionstreatment1completed
NCT00665470
Chemotherapy Followed by gp100 Lymphocytes and Aldesleukin to Treat Melanomatreatment2completed
NCT00631618
Clinical Trial of Sutent to Treat Metastatic Melanomatreatment2completed
NCT00626860
The Use of Dendritic Cell/Tumor Hybridomas as a Novel Tumor Vaccine in Patients With Advance MelanomaNo drug interventionstreatment1 / 2completed
NCT00627419
A Study Evaluating the Safety and Antitumor Activity of IPI-504, in Patients With Metastatic Melanomatreatment2terminated
NCT00612222
Anti-MART-1 F5 Cells Plus ALVAC MART-1 Vaccine to Treat Advanced Melanomatreatment2terminated
NCT00610311
Anti-gp100 Cells Plus ALVAC gp100 Vaccine to Treat Advanced Melanomatreatment2terminated
NCT00609011
Phase 1 Study of MPC-6827 and Temozolomide in Metastatic Melanomatreatment1 / 2completed
NCT00604136
Treatment of Metastatic Melanoma With Tumor Infiltrating Lymphocytes and IL-2 Following Lympho-depleting ChemotherapyNo drug interventionstreatment2unknown_status
NCT00591734
RAD001 Plus Bevacizumab in Metastatic Melanomatreatment2completed
NCT00571116
Disulfiram Plus Arsenic Trioxide In Patients With Metastatic Melanoma and at Least One Prior Systemic Therapytreatment1terminated
NCT00553618
Adjuvant, Combined Interleukin 2 (Proleukin) and DTIC (Dacarbazine) in High-risk Melanoma Patientstreatment2active_not_recruiting
NCT00527761
Taxotere/Temodar/Cisplatin Study in Melanoma Patientstreatment1completed
NCT00526617
A Phase I Study of ABT-888 in Combination With Temozolomide in Cancer Patientstreatment1completed
NCT00520299
Study of ADI-PEG 20 in Patients With Advanced MelanomaNo drug interventionstreatment1 / 2completed
NCT00402662
A Study of Everolimus in Combination With Imatinib in Metastatic Melanomatreatment2terminated
NCT00399113
Safety Study of 188Re-PTI-6D2 in Patients With Metastatic Melanomatreatment1completed
NCT00395070
A Phase 3 Pivotal Trial Comparing Allovectin-7® Alone vs Chemotherapy Alone in Patients With Stage 3 or Stage 4 Melanomatreatment3completed
NCT00383292
A Study of Tasisulam in Treating Participants With Malignant Melanomatreatment2completed
NCT00348088
Melanoma Biomarker StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT00328861
Natural Killer Cells Plus IL-2 Following Chemotherapy to Treat Advanced Melanoma or Kidney Cancertreatment2completed
NCT00314093
RFT-5-dgA in Patients With Metastatic MelanomaNo drug interventionstreatment2completed
NCT00314106
Chemotherapy, Irradiation, Cell Infusions, and Interleukin-2 to Treat Metastatic Melanomatreatment2completed
NCT00308607
Bevacizumab, Dacarbazine and Interferon-Alfa to Treat Metastatic Melanomatreatment2completed
NCT00304460
Mechanism of Action of High-Dose IL-2 (Aldesleukin) in Metastatic Melanoma and Kidney Cancertreatment1completed
NCT00279058
The Role of Peptide-loaded Dendritic Cells to Augment the Therapeutic Effect of Interleukin-2No drug interventionstreatment1 / 2completed
NCT00256282
Docetaxel and Vinorelbine Plus Sargramostim in Metastatic Malignant Melanomatreatment2completed
NCT00244816
Taxoprexin® Treatment for Advanced Eye MelanomaNo drug interventionstreatment2completed
NCT00226473
Standard Palliative Care Versus Standard Palliative Care Plus Polychemotherapy in Metastasized Malignant Melanomatreatment4unknown_status
NCT00223899
A Trial to Evaluate the Safety of Intratumoral VCL-IM01 Followed by Electroporation in Metastatic MelanomaNo drug interventionstreatment1completed
NCT00153569
Multiepitope Peptide Vaccination in Melanomatreatment2unknown_status
NCT00139360
Efficacy of Bevacizumab Monotherapy in Treatment of Metastatic Melanomatreatment2completed
NCT00044356
Phase II Trial of Allovectin-7® for Metastatic MelanomaNo drug interventionstreatment2completed
NCT03889782
High Dose IL-2 in Combination With Anti-PD-1 in Metastatic Melanoma and Renal Cell Carcinomatreatment2not_yet_recruiting
NCT03427398
Ibrutinib in Treating Patients With Refractory Metastatic Cutaneous Melanomatreatment2active_not_recruiting