Tinea Cruris (DBCOND0041588)

Identifiers

Synonyms

Jock Itch / Tinea cruris / Ringworm of scrotum / Tinea cruris (disorder) / Groin tinea / Ringworm of groin

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Amorolfine	A morpholine derivative commonly applied as a lacquer for onychomycosis but is also used for superficial dermatomycosis.	No drug targets
Butenafine	A topical antifungal used to treat tinea versicolor, tinea pedis, tinea cruris, and tinea corporis.	Squalene monooxygenasetarget Squalene monooxygenasetarget
Ciclopirox	A broad-spectrum topical antifungal agent used to treat mild to moderate onychomycosis of fingernails and toenails in immunocompetent patients.	Sodium/potassium-transporting ATPase subunit alpha-1target
Clioquinol	An antifungal cream used to treat a variety of fungal infections.	Kappa-type opioid receptortarget
Clotrimazole	A topical broad-spectrum antifungal agent used for the treatment of a wide variety of dermatophyte infections and candidiasis.	Intermediate conductance calcium-activated potassium channel protein 4target Cytochrome P450 2D6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 3A4enzyme Cytochrome P450 2B6enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 2A6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A7enzyme Lanosterol 14-alpha demethylasetarget Nuclear receptor subfamily 1 group I member 2target Hydroxycarboxylic acid receptor 2target Bile salt export pumptransporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter Ergosteroltarget C-X-C chemokine receptor type 2target
Econazole	A topical antifungal used to treat tinea pedis, tinea cruris, tinea corporis, cutaneous candidiasis and tinea versicolor.	Aromataseenzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A4enzyme Lanosterol 14-alpha demethylasetarget Nuclear receptor subfamily 1 group I member 2target
Fenticonazole	An imidazole antifungal used to treat a variety of topical fungal infections.	No drug targets
Flutrimazole	A topical antifungal used to treat pityriasis capitis and seborrheic dermatitis.	No drug targets
Griseofulvin	An antifungal agent used to treat a variety of superficial tinea infections and fungal infections of the fingernails and toes.	Keratin, type I cytoskeletal 12target Cytochrome P450 1A2enzyme Cytochrome P450 3A4enzyme Tubulin beta chaintarget
Miconazole	An azole antifungal with broad-spectrum activity used to treat fungal infections affecting the vagina, mouth and skin, including candidiasis.	Cytochrome P450 2C9enzyme Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Lanosterol 14-alpha demethylasetarget Nitric oxide synthase 3target Nitric oxide synthase, inducibletarget Cytochrome P450 11B1, mitochondrialenzyme Cytochrome P450 2A6enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2E1enzyme Nuclear receptor subfamily 1 group I member 2target Lanosterol 14-alpha demethylaseenzyme Aromataseenzyme Calcium-activated potassium channeltarget Voltage-gated Potassium Channelstarget Inward rectifier potassium channeltarget Voltage gated L-type calcium channeltarget Albumincarrier Cytochrome P450 2C8enzyme
Naftifine	An antifungal agent used to treat infections of the Tinea, Trichophyton, and Epidermophyton species.	Squalene monooxygenasetarget
Oxiconazole	A topical antifungal used to treat a variety of dermatophyte infections.	Lanosterol 14-alpha demethylasetarget Lanosterol synthasetarget Cytochrome P450 3A4enzyme Cytochrome P450 2C19enzyme Nuclear receptor subfamily 1 group I member 2target
Sulconazole	A topical antifungal agent used for the treatment of tinea cruris, tinea corporis, and tinea versicolor caused by susceptible fungal strains.	Cytochrome P450 1A2enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2D6enzyme Lanosterol 14-alpha demethylasetarget
Terbinafine	An allylamine antifungal used to treat dermatophyte infections of toenails and fingernails as well as other fungal skin infections.	Squalene monooxygenasetarget Cytochrome P450 2D6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 1A2enzyme Cytochrome P450 3A4enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C19enzyme Prostaglandin G/H synthase 1enzyme Albumincarrier alpha1-acid glycoproteincarrier ABC multidrug transporter MDR2transporter Squalene monooxygenasetarget
Tolnaftate	An antifungal agent used to treat various skin infections caused by fungi.	Squalene monooxygenasetarget Squalene monooxygenasetarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01885156	Evaluation of Efficacy and Safety of Naftin 1% Cream in Adolescent Subjects With Tinea Cruris	Naftifine	treatment	3	completed
NCT00750152	Multicenter Study of the Safety and Efficacy of NAFT-500 in Tinea Cruris	No drug interventions	treatment	3	completed
NCT01349998	Safety of a Topical Antifungal Treatment for Tinea Cruris, Tinea Pedis and Tinea Corporis	No drug interventions	Not Available	3	completed
NCT01105013	Evaluate the Efficacy and Safety of Tolnaftate Cream in the Treatment of Patients With Fungal Infections	Clotrimazole	treatment	3	unknown_status
NCT05881980	Efficacy and Safety of Terbinafine and Itraconazole	Itraconazole Terbinafine	treatment	2 / 3	not_yet_recruiting
NCT02767271	Maximal Use of Luliconazole Cream 1% in Pediatric Participants With Moderate to Severe Tinea Pedis or Tinea Cruris	Luliconazole	treatment	4	completed
NCT01342315	Topical Antifungal Treatment for Tinea Cruris	No drug interventions	treatment	3	completed
NCT03359070	Clinical Trial Comparing Dapaconazole Versus Miconazole in Patients With Tinea Cruris	Dapaconazole Miconazole	treatment	2	completed
NCT05363449	Safety, Tolerability, and Pharmacokinetics of UHE-103 Cream in Subjects With Tinea Cruris and/or Tinea Pedis	Naftifine	treatment	1	completed
NCT01712360	Pharmacokinetic Study of Pediatric Subjects With Tinea Cruris and Tinea Pedis	Naftifine	treatment	4	completed
NCT02394340	Study Evaluating the Drug Interaction Potential of Luliconazole Cream 1% in Participants With Tinea Pedis and Tinea Cruris	Luliconazole Omeprazole	treatment	4	completed