Increased Intra Ocular Pressure (IOP) (DBCOND0049485)
Identifiers
- Synonyms
- Elevated IOP / Increased IOP / Increased ocular pressure / Raised Ocular Pressure / Intraocular pressure raised / Increased ocular tension / Elevated Intraocular Pressure / Increase in intraocular pressure (IOP) / Increase in intraocular pressure / Intraocular pressure increased / Increased intraocular pressure / Raised Intraocular Pressure / Elevation in intraocular pressure / Elevation of intraocular pressure / Raised intraocular pressure (finding) / IOP increased / Raised IOP / Intraocular pressure high / Ocular tension increased / Tension ocular increased / Pressure intraocular increased
Associated Data
- Indicated Drugs and Targets
Drug Description Targets Betaxolol A cardioselective beta blocking agent commonly used to treat hypertension and elevated intraocular pressure (when administered ophthalmically).- Beta-1 adrenergic receptortarget
- Beta-2 adrenergic receptortarget
- Cytochrome P450 1A2enzyme
- Cytochrome P450 2D6enzyme
Bimatoprost A prostaglandin analog used to treat hypotrichosis of the eyelashes and intraocular pressure in open angle glaucoma or ocular hypertension.Brimonidine An alpha-2 adrenergic agonist used to treat glaucoma and ocular hypertension, as well as facial erythema in rosacea.Brinzolamide A carbonic anhydrase inhibitor used for the reduction of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.- Carbonic anhydrase 1target
- Carbonic anhydrase 2target
- Cytochrome P450 3A4enzyme
- Carbonic anhydrase 5A, mitochondrialtarget
- Carbonic anhydrase 4target
- Carbonic anhydrase 3target
- Cytochrome P450 2A6enzyme
- Cytochrome P450 2B6enzyme
- Cytochrome P450 2C8enzyme
- Cytochrome P450 2C9enzyme
Carbamoylcholine A direct acting miotic agent administered ophthalmically to decrease intraocular pressure after cataract surgery, and to induce miosis during surgery.Carteolol A beta adrenergic antagonist used to treat arrhythmia, angina, hypertension, and glaucoma.- Beta-2 adrenergic receptortarget
- Beta-1 adrenergic receptortarget
- Cytochrome P450 2D6enzyme
Dorzolamide A carbonic anhydrase inhibitor used to treat high intraocular pressure in ocular hypertension and open angle glaucoma.- Carbonic anhydrase 2target
- Carbonic anhydrase 1target
- Carbonic anhydrase 4target
- Cytochrome P450 2C9enzyme
- Carbonic anhydrase 3target
- Cytochrome P450 2B1enzyme
- Cytochrome P450 2E1enzyme
- Cytochrome P450 3A2enzyme
Latanoprost An isopropyl ester prodrug used to treat increased intraocular pressure.- Prostaglandin F2-alpha receptortarget
- Solute carrier organic anion transporter family member 2A1transporter
- Solute carrier family 22 member 6transporter
- Organic anion transporter 3transporter
- Corneal esterasesenzyme
Latanoprostene bunod A prostaglandin analog used to reduce ocular hypertension or treat open-angle glaucoma.Mannitol A sugar alcohol used to test for asthma, to reduce intracranial and intraocular pressure, to measure glomerular filtration rate, and to manage pulmonary symptoms associated with cystic fibrosis.- Mannitol dehydrogenaseenzyme
Netarsudil A rho kinase inhibitor used to reduce intraocular pressure in patients with open angle glaucoma or ocular hypertension.Omidenepag isopropyl An agonist of the prostaglandin EP2 receptor indicated for the reduction of elevated intraocular pressure.Pilocarpine A muscarinic agonist used to treat dry mouth and various ophthalmic conditions, such as presbyopia, increased intraocular pressure, and angle-closure glaucoma.Sodium chloride An ingredient found in a variety of nutritional products as a source of electrolytes and water.No drug targets Tafluprost An ophthalmic prostaglandin analog used to lower intraocular pressure in patients with ocular hypertension or open-angle glaucoma.Timolol A non-selective beta adrenergic blocker used in the treatment of elevated intraocular pressure in ocular hypertension or open angle glaucoma.- Beta-1 adrenergic receptortarget
- Beta-2 adrenergic receptortarget
- Cytochrome P450 2D6enzyme
- ATP-dependent translocase ABCB1transporter
- Cytochrome P450 2C19enzyme
- Endolysintarget
Travoprost A prostaglandin analog used in the treatment of elevated intraocular pressure due to open angle glaucoma or ocular hypertension.- Clinical Trials
Identifier Title Drug(s) Purpose Phase Status NCT00683501 Safety, Efficacy, and Pharmacokinetic Profile of DNB-001 in Subjects With Elevated Intraocular Pressure treatment 1 / 2 completed NCT02342288 Intraoperative Ocular Pressure in Lumbar Spine Fusion Patients No drug interventions Not Available Not Available completed NCT03500809 Aqueous Release to Treat IOP Spikes Post-cataract Surgery No drug interventions treatment Not Available unknown_status NCT01241175 The Effect of Intravenous Magnesium Sulfate on Intraocular Pressure Following Tracheal Intubation prevention 3 completed NCT00902200 A Study of AR-12286 in Patient With Elevated Intraocular Pressure (IOP) No drug interventions treatment 2 completed NCT05165290 Prospective, Double-masked, Randomized, Multi-center, Active-controlled, Parallel-group, 3-month Study Assessing the Safety & Ocular Hypotensive Efficacy of TC-002 Ophthalmic Solution Compared to Latanoprost Ophthalmic Solution 0.005% in Subjects With Elevated Intraocular Pressure treatment 3 unknown_status NCT00307918 Acupuncture for Elevated Intraocular Pressure No drug interventions treatment 3 terminated NCT01896180 Study to Compare the Safety and Efficacy of ALZ-1101 to Latanoprost in Patients With Intraocular Pressure Inadequately Controlled by Latanoprost treatment 2 completed NCT00409669 Intraocular Pressure Accuracy and Variability of the Barraquer Tonometer No drug interventions diagnostic Not Available unknown_status NCT01173471 A Phase IIa Study to Assess the Tolerability, Safety, and Efficacy of AZD4017 for Raised Intra-ocular Pressure basic_science 2 completed