Streptococcal Pharyngitis (DBCOND0056080)

Identifiers

Synonyms

Streptococcal Sore Throat / Pharyngitis streptococcal / Streptococcal pharyngitis / Streptococcal sore throat (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Azithromycin	A macrolide antibiotic used to treat a variety of bacterial infections.	23S ribosomal RNAtarget ATP-dependent translocase ABCB1transporter Cytochrome P450 3A4enzyme Protein-arginine deiminase type-4target ATP-binding cassette sub-family C member 2transporter
Benzethonium	A medication used as to clean hands and clean minor cuts and scrapes.	No drug targets
Cefaclor	A second generation cephalosporin used to treat a wide variety of infections in the body.	Penicillin-binding protein 1Atarget Solute carrier family 15 member 1transporter Solute carrier family 15 member 2transporter Penicillin-binding protein 3target Myeloperoxidaseenzyme Organic anion transporter 3transporter Bile salt export pumptransporter
Cefadroxil	A cephalosporin antibiotic used in the treatment of various bacterial infections, such as urinary tract infections, skin and skin structure infections, and tonsillitis.	Organic cation/carnitine transporter 2transporter Solute carrier family 15 member 1transporter Solute carrier family 15 member 2transporter Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Penicillin-binding protein 3target Penicillin-binding protein 1Atarget Penicillin-binding protein 1btarget Penicillin-binding protein 2Btarget
Cefdinir	A third generation cephalosporin used to treat susceptible Gram negative and Gram positive bacterial infections.	Myeloperoxidasetarget Penicillin-binding protein 2target PBP3target Organic cation/carnitine transporter 2transporter Solute carrier family 15 member 1transporter Solute carrier family 15 member 2transporter Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Peptidoglycan transpeptidasetarget
Cefditoren	A broad-spectrum third-generation cephalosporin antibiotic typically used to treat bacterial infections of the skin and respiratory tract.	Penicillin-binding protein 1Atarget Penicillin-binding protein 2Btarget
Cefixime	A third generation cephalosporin used to treat susceptible Gram-negative and Gram-positive bacterial infections.	Solute carrier family 15 member 1transporter Penicillin-binding proteintarget Penicillin-binding protein 2target Solute carrier family 22 member 7transporter Organic anion transporter 3transporter Solute carrier family 15 member 2transporter
Cefpodoxime	A third-generation cephalosporin antibiotic used in the treatment of various bacterial infections, including gonorrhea, community acquired pneumonia, and sinusitis.	Peptidoglycan synthase FtsItarget
Cefprozil	A cephalosporin antibiotic used in the treatment of various bacterial infections, such as pharyngitis, tonsillitis, otitis media, and uncomplicated skin infections.	Penicillin-binding protein 1Atarget Penicillin-binding protein 2xtarget Penicillin-binding protein 2Btarget
Ceftibuten	A third-generation cephalosporin antibiotic commonly used in the treatment of acute bacterial exacerbations of chronic bronchitis (ABECB), acute bacterial otitis media, pharyngitis, and tonsillitis.	Solute carrier family 15 member 1transporter Solute carrier family 15 member 2transporter Peptidoglycan synthase FtsItarget Penicillin-binding protein 1Atarget Penicillin-binding protein 1Btarget Penicillin-binding protein 2target Solute carrier family 22 member 6transporter Organic anion transporter 3transporter
Clarithromycin	A macrolide antibiotic used for the treatment of a wide variety of bacterial infections such as acute otitis, pharyngitis, tonsillitis, respiratory tract infections, uncomplicated skin infections, and helicobacter pylori infection.	50S ribosomal protein L10target Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme ATP-dependent translocase ABCB1transporter Solute carrier family 22 member 7transporter Voltage-gated inwardly rectifying potassium channel KCNH2target Solute carrier organic anion transporter family member 1B1target Solute carrier organic anion transporter family member 1B3target Bile salt export pumptransporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter
Phenoxymethylpenicillin	A penicillin antibiotic used to prevent and treat mild to moderately severe infections in the respiratory tract, skin, and soft tissues.	Penicillin-binding protein 1Atarget MecA PBP2' (penicillin binding protein 2')target D-alanyl-D-alanine carboxypeptidase DacBtarget Penicillin acylasetarget Solute carrier family 15 member 1target
Sulfamerazine	An antibacterial agent used in the treatment of various bacterial infections, such as bronchitis, prostatitis, and urinary tract infections.	Dihydropteroate synthasetarget Albumincarrier
Sulfamethazine	An antibacterial agent used in the treatment of various bacterial infections, such as bronchitis, prostatitis, and urinary tract infections.	Dihydropteroate synthasetarget Albumincarrier Arylamine N-acetyltransferaseenzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT04247243	Rapid POC GAS Diagnostics in the Paediatric ED	No drug interventions	diagnostic	Not Available	completed
NCT01806103	Antimicrobial Stewardship for Primary Care Pediatricians	No drug interventions	treatment	Not Available	completed
NCT01558804	GRoup A StrePtococcus	No drug interventions	Not Available	Not Available	recruiting
NCT05521568	Diagnostic Accuracy of Rapid Molecular Tests for Group A Streptococcal Pharyngitis Using Saliva Samples	No drug interventions	Not Available	Not Available	recruiting
NCT01310361	Once-daily Therapy for Streptococcal Pharyngitis	Amoxicillin Benzylpenicillin	treatment	1	completed
NCT02068469	In Vitro Diagnostic Device for the Detection of Strep A	No drug interventions	Not Available	Not Available	completed