NCT01891695
OPSCC N0 Nodal Control With Reduced IMRT No drug interventions treatment Not Available terminated NCT06662058
Remote Audiometry to Monitor for Treatment-Related Hearing Loss in Patients with Head and Neck Squamous Cell Cancer Receiving Cisplatin And/or Radiation No drug interventions supportive_care Not Available not_yet_recruiting NCT03258554
Radiation Therapy With Durvalumab or Cetuximab in Treating Patients With Locoregionally Advanced Head and Neck Cancer Who Cannot Take Cisplatin treatment 2 / 3 active_not_recruiting NCT03952585
De-intensified Radiation Therapy With Chemotherapy (Cisplatin) or Immunotherapy (Nivolumab) in Treating Patients With Early-Stage, HPV-Positive, Non-Smoking Associated Oropharyngeal Cancer treatment 2 / 3 active_not_recruiting NCT05522881
The Registry Study of Genetic Alterations of Oropharyngeal Cancer in Taiwan No drug interventions Not Available Not Available recruiting NCT06356272
Oropharynx (OPX) Biomarker Trial No drug interventions Not Available Not Available recruiting NCT04718415
Neoadjuvant Sintilimab in Combination With Carboplatin and Nab-paclitaxel in Resectable Oral Cavity or Oropharyngeal Squamous Cell Carcinoma treatment 2 active_not_recruiting NCT06314711
Ex Vivo 3D-ultrasound for Oropharyngeal Cancer No drug interventions treatment Not Available completed NCT06362421
Saliva Testing for High-Risk Human Papillomavirus Infection Oral Cavity and Pharynx Cancer No drug interventions Not Available Not Available not_yet_recruiting NCT06532279
Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer supportive_care 2 not_yet_recruiting NCT04222543
Imaging of Tumour Microenvironment in Patients With Oropharyngeal Head and Neck Squamous Cell Carcinoma Using RGD PET/CT Imaging No drug interventions other 2 unknown_status NCT03618654
Durvalumab With or Without Metformin in Treating Participants With Head and Neck Squamous Cell Carcinoma treatment 0 completed NCT06009861
Neoadjuvant Tislelizumab Plus Chemotherapy for Locally Advanced Oral/Oropharyngeal Cancer (NeoSPOT) treatment 2 recruiting NCT01874171
Determination of Cetuximab Versus Cisplatin Early and Late Toxicity Events in HPV+ OPSCC treatment 3 unknown_status NCT04572100
Pilot Study of Chemotherapy for HPV-Associated Oropharyngeal Cancer other 1 completed NCT04220749
Radiotherapy vs. Trans-Oral Surgery for HPV-Negative Oropharyngeal Squamous Cell Carcinoma No drug interventions treatment 2 recruiting NCT05098119
Neoadjuvant Sintilimab Combined With Reduction of Cycles of Chemotherapy in Resectable Oral Cavity or Oropharyngeal Squamous Cell Carcinoma (OOC-002) treatment 2 recruiting NCT05136196
BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study treatment 2 suspended NCT02072148
The Sinai Robotic Surgery Trial in HPV Positive Oropharyngeal Squamous Cell Carcinoma (SCCA) (SIRS TRIAL) No drug interventions treatment Not Available completed NCT06323460
Adaptive De-intensified Radiotherapy Using Circulating Tumor DNA in HPV- Associated Oropharyngeal Cancer treatment 2 recruiting NCT04609280
Selective Avoidance of Nodal VolumEs at Minimal Risk (GCC 20110) No drug interventions treatment 2 active_not_recruiting NCT01819480
Efficacy and Safety of TORS for SCCA No drug interventions treatment Not Available active_not_recruiting NCT04965792
Post-treatment Surveillance in HPV+ Oropharyngeal SCC No drug interventions Not Available Not Available active_not_recruiting NCT06055868
People Living With HIV, Oral and Oropharyngeal Cancer, and Health Equity No drug interventions Not Available Not Available not_yet_recruiting NCT05268614
Risk Adapted De-Intensification of Radio-Chemotherapy for Oropharyngeal Squamous Cell Carcinoma treatment 2 recruiting NCT02582008
Bupropion Hydrochloride or Patient's Choice for Smoking Cessation in Patients With Squamous Cell Head and Neck Cancer Undergoing Radiation Therapy With or Without Chemotherapy prevention 0 terminated NCT05539638
The Role of Circulating Tumour DNA in Head and Neck Cancer No drug interventions Not Available Not Available recruiting NCT05582590
Autologous T Cells Targeting HPV16 HPV18 & Survivin in Patients With R/R HPV-related Oropharyngeal Cancers treatment 1 not_yet_recruiting NCT06084845
Testing the Addition of an Investigational Drug, Xevinapant, to Usual Radiation Therapy Plus Cisplatin/Carboplatin for Patients With Head and Neck Cancer treatment 2 withdrawn NCT03611205
Interim Digital PET/CT in Predicting Outcomes for Participants With Locally Advanced Oropharyngeal Cancer Undergoing Chemoradiation Therapy No drug interventions diagnostic Not Available withdrawn NCT06138483
A New Mutational and Epigenetic Signature to Predict Early OPSCC Relapse No drug interventions Not Available Not Available recruiting NCT06174428
Validity of Viome's Oral/Throat Cancer Test No drug interventions Not Available Not Available not_yet_recruiting NCT04852328
Three Schedules of CUE-101 Administered Before Surgery or Definitive Chemoradiation Therapy in HLA-A*0201 Positive Patients With Locally Advanced, HPV16-Positive Oropharyngeal Squamous-Cell Carcinoma No drug interventions treatment 2 recruiting NCT03410615
Cisplatin + Radiotherapy vs Durvalumab + Radiotherapy Followed by Durvalumab vs Durvalumab + Radiotherapy Followed by Tremelimumab + Durvalumab in Intermediate-Risk HPV-Positive Oropharyngeal SCC treatment 2 active_not_recruiting NCT03618134
Stereotactic Body Radiation Therapy and Durvalumab With or Without Tremelimumab Before Surgery in Treating Participants With Human Papillomavirus Positive Oropharyngeal Squamous Cell Caner treatment 1 / 2 terminated NCT03727594
Radioguided Selective Neck Dissection for Staging and Treatment of Oral Cavity and Oropharyngeal Squamous Cell Carcinoma No drug interventions Not Available Not Available unknown_status NCT02156180
Identification of Breath Biomarkers in Head and Neck Squamous Cell Carcinoma No drug interventions Not Available Not Available suspended NCT04564989
Prospective Observational Study to Validate Circulating HPVDNA and Prognostic Genomic Biomarkers in HPV-associated OPSCC No drug interventions Not Available Not Available recruiting NCT04801472
Optimisation of Potential Dental Implant Sites Protection for Rehabilitation in Patients With Head and Neck Cancer: Impact of Virtual Implants Visualisation on Dosimetry (OPPIDOM) No drug interventions other Not Available unknown_status NCT03623646
Cisplatin or ImmunoTHerapy in Association With Definitive Radiotherapy in HPV-related oropharyngEal Squamous Cell Carcinoma: a Randomized Phase II Trial. No drug interventions treatment 2 completed NCT05333523
Personalized Elective Neck Irradiation Guided by Sentinel Lymph Node Biopsy in Larynx and Pharynx Cancer. The PRIMO Study. No drug interventions treatment 3 recruiting NCT03421470
Docetaxel and Radiation Therapy in Treating Patients With HPV Positive Oropharynx Cancer treatment 3 recruiting NCT05894083
A Phase II Study for p16+ Oropharyngeal Cancer PerSonalized De-escalation Treatment at University of MIchigan (CuSToMIze) No drug interventions treatment 2 recruiting NCT05119036
Adjuvant Treatment Deintensification After Transoral Surgery for Human Papillomavirus-Positive Squamous Cell Carcinoma No drug interventions treatment Not Available active_not_recruiting NCT04104945
p16+ Oropharyngeal Cancer Radiation Optimization Trial Reducing Elective Treatment Volumes (PROTEcT) No drug interventions treatment Not Available recruiting NCT01663259
Reduced-intensity Therapy for Oropharyngeal Cancer in Non-smoking HPV-16 Positive Patients treatment Not Available completed NCT05962242
HPV DNA-Guided Radiotherapy De-intensification of Head and Neck Squamous Cell Carcinoma No drug interventions treatment 2 not_yet_recruiting NCT04398524
A Phase II Study of Cemiplimab and ISA101b in Patients With Recurrent/Metastatic HPV16 Positive OPC treatment 2 active_not_recruiting NCT06112535
Prospective Clinical Study to Assess the Safety and Efficacy of Versius, in Transoral Robotic Surgery No drug interventions treatment Not Available recruiting NCT06380686
Head and Neck Carcinoma Clinical Research Platform for Molecular and Blood-based Biomarkers, Treatment and Outcome No drug interventions Not Available Not Available not_yet_recruiting NCT01921426
A Phase 1 Dose Escalation Study of GC4419 in Combination With Chemoradiation for Squamous Cell Cancer of the Head & Neck supportive_care 1 completed NCT03148665
Saliva-based Detection of CD44 No drug interventions Not Available Not Available completed NCT03370276
Cetuximab & Nivolumab in Patients With Recurrent/Metastatic Head & Neck Squamous Cell Carcinoma treatment 1 / 2 active_not_recruiting NCT06030440
De-Intensification of Postoperative Radiotherapy in Patients With Squamous Cell Carcinoma of the Head and Neck No drug interventions treatment 2 / 3 recruiting NCT05312710
Safety and Efficacy of APG-157 in Head and Neck Cancer treatment 2 recruiting NCT02552550
Swallowing, Speech and Quality of Life of Patients With Carcinoma of the Oropharynx No drug interventions Not Available Not Available terminated NCT06061705
Identification of Individual Histological and Blood Markers in Patients With Recurrent or Metastatic Upper Aerodigestive Tract Squamous Cell Carcinoma in Response to Immunotherapies No drug interventions other Not Available not_yet_recruiting NCT05540899
Testing the Safety of Giving a Standard Dose of Radiation Over a Shorter Period of Time for Patients Who Had Surgery for Intermediate-Risk Head and Neck Cancer No drug interventions treatment 1 recruiting NCT03669718
A Randomized Phase 2 Study of Cemiplimab ± ISA101b in HPV16-Positive OPC treatment 2 active_not_recruiting NCT04031534
Study of Hypoxia Measured in F-Miso PET/Scan and MRI in Patients With Squamous Cells Carcinoma No drug interventions other 2 unknown_status NCT04151134
Evaluation of Tongue Base MucOsectomy & Step sErial Sectioning No drug interventions Not Available Not Available recruiting NCT01181648
Long-Term Impact of Human Papillomavirus (HPV) on Quality of Life No drug interventions Not Available Not Available completed NCT01586182
Stereotactic Boost for Oropharyngeal Squamous Cell Carcinoma No drug interventions treatment 1 / 2 withdrawn NCT05608369
Vorinostat in Combination With Chemoradiation in Locally Advanced HPV Negative HNSCC treatment 2 not_yet_recruiting NCT05918510
Observational Study of Viral BIOmarkers and microRNAs in Tumors Orofarynx and Occult Tumors Positive for Papilloma Virus No drug interventions Not Available Not Available recruiting NCT01314755
A Trial of Perioperative Immune Enhancing Feed in Patients Undergoing Surgery for Head and Neck Cancer No drug interventions treatment Not Available completed NCT01088802
Treatment De-Intensification for Squamous Cell Carcinoma of the Oropharynx diagnostic 2 completed NCT01772706
Laser Mucite ORL : Effectiveness of Laser Therapy for Mucositis Induced by a Radio-chemotherapy in Head and Neck Cancer No drug interventions treatment Not Available unknown_status NCT01439724
Low-level Laser Therapy to Prevent Oral Mucositis in Head and Neck Patients No drug interventions prevention 3 completed NCT02035735
Interest of Narrow Band Imaging in Detection of Upper Aerodigestive Cancers No drug interventions diagnostic Not Available completed NCT05451303
Detection of Oral and Throat Cancers Using OralViome Cancer Testing System No drug interventions Not Available Not Available recruiting NCT04445064
Activity and Safety of Peptide-based Immunotherapy in Patients With Squamous Cell Carcinoma of the Head and Neck. No drug interventions treatment 2 unknown_status NCT04916002
A Trial To Find Out If Vidutolimod Together With Cemiplimab Is Safe And If It Works In Adult Participants With Advanced Cancer Or Metastatic Cancer treatment 2 active_not_recruiting NCT03381183
IRX-2 Regimen and Durvalumab, for Incurable H&N Squamous Cell Carcinoma treatment 1 active_not_recruiting NCT02663583
Intensity-Modulated Proton Therapy (IMPT) or TransOral Robotic Surgery (TORS) for the Treatment of Low-Risk Oropharynx Squamous Cell No drug interventions Not Available Not Available unknown_status NCT03829722
Radiotherapy, Carboplatin/Paclitaxel and Nivolumab for High Risk HPV-related Head and Neck Cancer treatment 2 completed NCT05582122
SURVEILLE-HPV: Evaluation of HPV16 Circulating DNA as Biomarker to Detect the Recurrence, in Order to Improve Post Therapeutic Surveillance of HPV16-driven Oropharyngeal Cancers No drug interventions diagnostic 2 recruiting NCT05649865
Monitoring and Early Response Evaluation Using HPV DNA - A Study on Patients With HPV-positive Throat Cancer (MER-HPV) No drug interventions Not Available Not Available recruiting NCT05904327
Circulating Biomarkers in Oropharyngeal Cancers No drug interventions Not Available Not Available active_not_recruiting NCT06088381
Selective Adjuvant Therapy for HPV-mediated Oropharynx SCCs Based on Residual Circulating Tumor DNA Levels (SAVAL) No drug interventions treatment 2 recruiting NCT04124198
Quality of Life After Primary TORS vs IMRT for Patients With Early-stage Oropharyngeal Squamous Cell Carcinoma treatment Not Available recruiting NCT04892875
A Study of Concurrent Chemoradiation in Combination With or Without PD1 Inhibitor AB122 Adenosine 2a Receptor / Adenosine 2b Receptor Inhibitor AB928 Therapies in Locally Advanced Head and Neck Cancers treatment 1 withdrawn NCT04359199
QUantitative Assessment of Swallowing After Radiation (QUASAR) Not Available Not Available recruiting NCT04725396
Study Comparing Fibula Free-flap MR With or Without PVP in Patients With OOPC No drug interventions supportive_care Not Available recruiting NCT05278039
Training Swallowing Initiation During Expiration No drug interventions treatment Not Available recruiting NCT04858269
First Line Weekly Chemo/Immunotherapy for Metastatic Head/Neck Squamous Cell Carcinoma Patients treatment 2 recruiting NCT03715946
Adjuvant De-Escalated Radiation + Adjuvant Nivolumab for Intermediate-High Risk P16+ Oropharynx Cancer treatment 2 active_not_recruiting