| Acetaminophen | An analgesic drug used alone or in combination with opioids for pain management, and as an antipyretic agent. | |
| Acetylsalicylic acid | A salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events. | |
| Buprenorphine | A partial opioid agonist used for management of severe pain that is not responsive to alternative treatments. Also used for maintenance treatment of opioid addiction. | |
| Butorphanol | An opioid agonist-antagonist used to treat moderate to severe pain. | |
| Cannabidiol | An active cannabinoid used as an adjunctive treatment for the management of seizures associated with Lennox-Gastaut syndrome or Dravet syndrome and symptomatic relief of moderate to severe neuropathic pain or other painful conditions, like cancer. | |
| Codeine | An opioid analgesic used to treat moderate to severe pain when the use of an opioid is indicated. | |
| Dihydrocodeine | An opioid analgesic agent used for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. | |
| Estradiol | An estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate. | |
| Hydrocodone | An opioid agonist used as an analgesic and antitussive agent. | |
| Ibuprofen | An NSAID and non-selective COX inhibitor used to treat mild-moderate pain, fever, and inflammation. | |
| Levorphanol | An opioid analgesic used to treat moderate to severe pain. | |
| Meperidine | An opioid agonist with analgesic and sedative properties used to manage severe pain. | |
| Metamizole | An antipyretic and analgesic drug used to relieve severe and persistent fever and pain. | |
| Methadone | An opioid analgesic indicated for management of severe pain that is not responsive to alternative treatments. Also used to aid in detoxification and maintenance treatment of opioid addiction. | |
| Methoxyflurane | For use in the induction and maintenance of general anesthesia | |
| Morphine | An opioid agonist used for the relief of moderate to severe acute and chronic pain. | |
| Nalbuphine | An opioid agonist-antagonist used to treat pain, for pre and postoperative analgesia, and for analgesia in labor and delivery. | |
| Naloxone | An opioid receptor antagonist used to rapidly reverse an opioid overdose. Also included in some drug formulations as an abuse deterrent to prevent injection. | |
| Naltrexone | A narcotic antagonist used in opioid overdose. | |
| Norethisterone | A synthetic second-generation progestin used for contraception, prevention of endometrial hyperplasia in hormone replacement therapy, and in the treatment of other hormone-mediated illnesses such as endometriosis. | |
| Oxycodone | An opioid used in the management of moderate to severe pain. | |
| Oxymorphone | An opioid analgesic used in the management of moderate-to-severe pain and for analgesic therapies. | |
| Pentazocine | An analgesic used to treat moderate to severe pain. | |
| Piritramide | A synthetic opioid used in the treatment of severe pain. | No drug targets |
| Relugolix | An oral GnRH receptor antagonist for androgen deprivation therapy in the treatment of advanced prostate cancer. | |
| Tapentadol | An opioid used to manage severe pain that has not responded to non-opioid medications, and for which opioid analgesic therapy is appropriate. | |
| Tilidine | A synthetic opioid indicated in the treatment of severe pain. | No drug targets |
| Tramadol | A centrally-acting opioid agonist and SNRI (serotonin/norepinephrine reuptake inhibitor) used for the management of moderate to severe pain in adults. | |
| Zucapsaicin | A topical analgesic used as an adjunct to relieve severe pain of osteoarthritis of the knee in selected adult patients. | |