Naloxone is an opioid receptor antagonist used to rapidly reverse an opioid overdose. Also included in some drug formulations as an abuse deterrent to prevent injection. Naloxone is an opioid antagonist medication used to block or reverse the effects of opioid drugs, particularly within the setting of drug overdoses which are rapidly becoming a leading cause of death worldwide.
- Mechanism
- Curator reviewed · 4 references
Naloxone is a competitive inhibitor of the µ-opioid receptor. Naloxone antagonizes the action of opioids, reversing their effects. If a patient has not taken opioids, naloxone does not have a significant effect on patients.
- Primary indication
- Naloxone nasal sprays are indicated for the reversal of an opioid overdose or suspected opioid overdose: it is intended for immediate administration as emergency therapy in settings where opioids may be present.Curator reviewed · 12 structured indications
- Formula / weight
- C19H21NO4 · 327.3743 g/mol (avg)
- First approval
- Canada, 2001 · United States, 1971 · European Union, 2016
- Code names
- EN 1530 Base
- Brand names
Resolves to
UZHSEJADLWPNLE-GRGSLBFTSA-NSMILESOC1=CC=C2C[C@H]3N(CC=C)CC[C@@]45[C@@H](OC1=C24)C(=O)CC[C@@]35OWhat you can answer from here — as of September 21, 2026
Which drugs share a target with Naloxone, and which of those have an active Phase 3 trial?
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