- Opioid Antagonists
- Accession Number
Agents inhibiting the effect of narcotics on the central nervous system.
Drug Drug Description Pentazocine An analgesic used to treat moderate to severe pain. Naltrexone A narcotic antagonist used in opioid overdose. Nalbuphine An opioid agonist-antagonist used to treat pain, for pre and postoperative analgesia, and for analgesia in labor and delivery. Buprenorphine A partial opioid agonist used for management of severe pain that is not responsive to alternative treatments. Also used for maintenance treatment of opioid addiction. Naloxone An opioid receptor antagonist used to rapidly reverse an opioid overdose. Also included in some drug formulations as an abuse deterrent to prevent injection. Diprenorphine Diprenorphine is indicated to reverse the effects of powerful opioids including etorphine and carfentanil, often used for tranquilizing large animals. This drug is not approved for use in humans. Methylnaltrexone A μ-opioid antagonist used for the treatment of opioid-induced constipation in palliative patients that are inadequately responding to laxative therapy. Naloxegol A peripherally-selective opioid antagonist used to treat opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain. Alvimopan An opioid antagonist used to reduce healing time of the upper and lower gastrointestinal tract following surgical procedures that involve bowel resection with primary anastomosis. Naldemedine An opioid antagonist used to to treat opioid-induced constipation. Nalmefene An opioid antagonist used to reduce alcohol consumption in adults with alcohol dependence and treat and prevent opioid overdose. Levallorphan For the complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids. Butorphanol An opioid agonist-antagonist used to treat moderate to severe pain. Nalorphine Used to reverse opioid overdose. Axelopran Axelopran has been used in trials studying the treatment of OIC and Opioid-induced Constipation. Samidorphan A novel opioid-system modulator, similar to naltrexone, that functions primarily as a μ-opioid receptor antagonist in vivo and is used primarily in combination with antipsychotics to reduce their metabolic dysfunction-associated adverse effects. Ondelopran Ondelopran has been used in trials studying the treatment of Alcohol Dependence. Meptazinol Not Annotated Eluxadoline A mixed mu-opioid receptor agonist used to treat irritable bowel syndrome with diarrhea. Dezocine Indicated in the treatment of moderate to severe pain. LY-2456302 Ly2456302 has been used in trials studying the health services research and basic science of Anxiety Disorders and Alcohol Dependence.
- Drugs & Drug Targets