Kappa-type opioid receptor

BE0000632ProteinHumansOPRK1

G protein-coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. It is acted on by 84 drugs in DrugBank.

Gene name
OPRK1
UniProtKB entry
P41145Swiss-Prot
Cellular location
Cell membrane
Residues / weight
380 residues · 42,645 Da
Also known as
K-OR-1 · KOR-1 · OPRK

Resolves to

Protein
UniProtP41145UniProt nameOPRK_HUMAN
Gene
HGNCHGNC:8154NCBI Gene4986GenBank532060GeneCardsOPRK1
Pharmacology
IUPHAR/GtoPdb318KEGGhsa:4986
Structure
PDB22EMPDB22ESPDB4DJH
Drugs

What you can answer from here — as of September 07, 2019

84DrugsApproved to experimental, with action, bond type and pharmacological action
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6Clinical trialsTrials of drugs acting on it, by phase and status
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17GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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229+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Kappa-type opioid receptor, how selective are they, and which programs against it are still in active trials?

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