DNA gyrase subunit B

BE0002388ProteinStaphylococcus aureusgyrB

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. It is acted on by 29 drugs in DrugBank.

Gene name
gyrB
UniProtKB entry
P0A0K8Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
644 residues · 72,539 Da
Also known as
5.6.2.2 · 5.99.1.3

Resolves to

Protein
UniProtP0A0K8UniProt nameGYRB_STAAU
Gene
NCBI Gene23195875
Structure
PDB3G75PDB3G7BPDB3TTZ
Drugs

What you can answer from here — as of September 07, 2019

29DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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36+ReferencesStructured and connected to the statements they support
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Which approved drugs act on DNA gyrase subunit B, how selective are they, and which programs against it are still in active trials?

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