Dopamine receptor D3

BE0000581ProteinHumansDRD3

G protein-coupled receptor for dopamine, a catecholamine neurotransmitter hormone that functions as the brain's 'reward chemical', driving motivation, reinforcement learning and pleasure (PubMed:19520868, PubMed:33548201, PubMed:37221270, PubMed:39237617, PubMed:39984436, PubMed:8301582). It is acted on by 69 drugs in DrugBank.

Gene name
DRD3
UniProtKB entry
P35462Swiss-Prot
Cellular location
Cell membrane
Residues / weight
400 residues · 44,194 Da
Also known as
Dopamine D3 receptor

Resolves to

Protein
UniProtP35462UniProt nameDRD3_HUMAN
Gene
HGNCHGNC:3024NCBI Gene1814GenBank927342GeneCardsDRD3
Pharmacology
IUPHAR/GtoPdb216KEGGhsa:1814
Structure
PDB3PBLPDB7CMUPDB7CMV
Drugs

What you can answer from here — as of September 08, 2026

69DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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210+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Dopamine receptor D3, how selective are they, and which programs against it are still in active trials?

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