Solute carrier organic anion transporter family member 1C1

BE0003660ProteinHumansSLCO1C1

Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones L-thyroxine (T4), L-thyroxine sulfate (T4S), and 3,3',5'-triiodo-L-thyronine (reverse T3, rT3) at the plasma membrane (PubMed:12351693, PubMed:18566113, PubMed:19129463, PubMed:40680733). It is acted on by 20 drugs in DrugBank.

Gene name
SLCO1C1
UniProtKB entry
Q9NYB5Swiss-Prot
Cellular location
Cell membrane
Residues / weight
712 residues · 78,696 Da
Also known as
OAT-RP-5 · OATP-14 · OATP-F · OATP-RP5 · OATP14

Resolves to

Protein
UniProtQ9NYB5UniProt nameSO1C1_HUMAN
Gene
HGNCHGNC:13819NCBI Gene53919GenBank7839587GeneCardsSLCO1C1
Pharmacology
KEGGhsa:53919
Structure
PDB9DXOPDB9DXPPDB9MR5
Drugs

What you can answer from here — as of September 07, 2019

20DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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38+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Solute carrier organic anion transporter family member 1C1, how selective are they, and which programs against it are still in active trials?

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