Human C1-esterase inhibitor is a C1 inhibitor used to prevent angioedema attacks associated with hereditary angioedema. C1 Esterase Inhibitor (Human) is composed of purified endogenous complement component-1 esterase inhibitor (hC1INH) isolated from human plasma.
- Mechanism
- Curator reviewed · 1 reference
The C1 esterase inhibitor binds to proteins such as C1s, kallikrein, factor XIIa, and XIa and irreversibly inactivates them. Patients with hereditary angioedema have low levels of C1 esterase inhibitors. By providing patients with C1 esterase inhibitors, this may prevent contact system activation, which prevents increases in vascular permeability. Manifestations of hereditary angioedema may be prevented by preventing increases in vascular permeability.
- Primary indication
- Intravenous and subcutaneous formulations of the human C1-esterase inhibitor are indicated for routine prophylaxis against acute attacks of hereditary angioedema in patients six years of age and older.Curator reviewed · 4 structured indications
- Formula / weight
- 68000.0 Da
- First approval
- Canada, 2014 · United States, 2008 · European Union, 2016
- Also known as
- C1 Esterase Inhibitor (Human) · C1 inhibitor · C1 inhibitor (human) · C1 inhibitor human · C1-esterase inhibitor, human
- Code names
- RVG-19303
- Brand names
Resolves to
What you can answer from here — as of June 15, 2026
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