Polynucleotides

Name
Polynucleotides
Accession Number
DBCAT001405
Description
Not Available
Drugs
DrugDrug Description
PegaptanibA selective vascular endothelial growth factor (VEGF) antagonist used for the treatment of neovascular (wet) age-related macular degeneration.
DefibrotideA mixture of single-stranded oligonucleotides used in the treatment of severe hepatic veno-occlusive disease with renal or pulmonary dysfunction following hematopoietic stem-cell transplantation.
LErafAONIntended for the treatment of various forms of cancer.
AGRO100Investigated for use/treatment in cancer/tumors (unspecified), kidney cancer, leukemia (myeloid), and pancreatic cancer.
LY2181308Investigated for use/treatment in cancer/tumors (unspecified) and solid tumors.
LY2275796Investigated for use/treatment in cancer/tumors (unspecified) and solid tumors.
Egaptivon pegolPlatelet aggregation, thrombosis and acute coronary syndromes
GTI-2501Investigated for use/treatment in prostate cancer and solid tumors.
MipomersenAn oligonucleotide drug used for the treatment of homozygous familial hypercholesterolemia.
CPG 10101Investigated for use/treatment in hepatitis (viral, C) and viral infection.
GEM-231Investigated for use/treatment in solid tumors.
EteplirsenAn antisense oligonucleotide used to treat Duchenne muscular dystrophy (DMD) only in patients who are confirmed to have a specific type of mutation.
ApatorsenInvestigated for use/treatment in cancer/tumors (unspecified).
AEG35156Investigated for use/treatment in cancer/tumors (unspecified) and leukemia (myeloid).
AlicaforsenInvestigated for use/treatment in crohn's disease and ulcerative colitis.
PegnivacoginInvestigated for use/treatment in thrombosis, coronary artery disease, and vascular diseases.
AprinocarsenInvestigated for use/treatment in lung cancer.
EdifoligideInvestigated for use/treatment in cardiac surgery, peripheral vascular disease, and kidney disease.
AbetimusInvestigated for use/treatment in kidney disease and systemic lupus erythematosus.
FomivirsenIndicated for the local treatment of cytomegalovirus (CMV) retinitis in patients with acquired immunodeficiency syndrome (AIDS), when other therapy has been ineffective or is considered unsuitable [FDA Label, L1428].
MiravirsenMiravirsen has been investigated for the treatment of Hepatitis C and Hepatitis C, Chronic.
NusinersenA medication used to treat spinal muscular atrophy.
DrisapersenNot Annotated
IMO-2055Investigated for use/treatment in renal cell carcinoma, solid tumors, and lung cancer.
ISS-1018Investigated for use/treatment in colorectal cancer, hepatitis (viral, B), and lymphoma (non-hodgkin's). ISS 1018 is currently being investigated in combination with HBsAg vaccine as a prophylactic treatment for to prevent...
NF-kappaB DecoyInvestigated for use/treatment in atopic dermatitis, inflammatory disorders (unspecified), and skin infections/disorders.
MongersenMongersen is under investigation in clinical trial NCT02957474 (A Study to Evaluate the Effect of Food, Formulation Strength, and a Proton Pump Inhibitor on GED 0301 Pharmacokinetics in Healthy Adult...
GTI-2040GTI-2040 is under investigation in clinical trial NCT00084643 (GTI-2040, Oxaliplatin, and Capecitabine in Treating Patients With Locally Advanced or Metastatic Colorectal Cancer or Other Solid Tumors).
VolanesorsenVolanesorsen is under investigation in clinical trial NCT02639286 (Efficacy, Safety and Tolerability of ISIS 304801 in People With Partial Lipodystrophy With an Open-Label Extension).
ARC-19499ARC-19499 is under investigation in clinical trial NCT01191372 (First-in-Human and Proof-of-Mechanism Study of ARC19499 Administered to Hemophilia Patients).
AganirsenAganirsen is under investigation in clinical trial NCT02947867 (Trial of Aganirsen in iCRVO Patients at Risk of Developing NVG).
CenersenCenersen is under investigation in clinical trial NCT02243124 (A Study of Aezea® (Cenersen) in Transfusion Dependent Anemia Associated With Myelodysplastic Syndrome (MDS)).
Lexaptepid PegolLexaptepid Pegol has been used in trials studying the treatment of Anemia, Inflammation, Chronic Diseases, End Stage Renal Disease, and Anemia of Chronic Disease.
OblimersenNot Annotated
InotersenAn antisense oligonucleotide used to treat polyneuropathy of hereditary transthyretin-mediated amyloidosis.
DanvatirsenDanvatirsen is under investigation in clinical trial NCT03334617 (Phase II Umbrella Study of Novel Anti-cancer Agents in Patients With NSCLC Who Progressed on an Anti-PD-1/PD-L1 Containing Therapy.).
ImetelstatImetelstat is under investigation in clinical trial NCT01916187 (Imetelstat Given Intravenously Alone and With Standard 13-Cis-Retinoic Acid in Children With Neuroblastoma).
RadavirsenRadavirsen is under investigation in clinical trial NCT01375985 (Safety Study of Single Administration Intravenous Treatment for Influenza).
Adenylyl-(3'-5')-uridine 3'-monophosphateNot Available
ViltolarsenAn antisense phosphorodiamidate morpholino oligonucleotide specific for exon 53 of the human DMD gene that is capable of inducing exon 53 skipping to produce a functional truncated dystrophin protein in Duchenne muscular dystrophy patients with specific underlying mutations.
Drugs & Drug Targets
DrugTargetType
PegaptanibNeuropilin-1target
DefibrotideAdenosine receptor A1target
DefibrotideAdenosine receptor A2atarget
DefibrotideAdenosine receptor A2btarget
LErafAONRAF proto-oncogene serine/threonine-protein kinasetarget
AGRO100NF-kappa-B essential modulatortarget
LY2181308Baculoviral IAP repeat-containing protein 5target
LY2275796Eukaryotic translation initiation factor 4Etarget
Egaptivon pegolvon Willebrand factortarget
Egaptivon pegolPlatelet glycoprotein Ib alpha chaintarget
MipomersenmRNA of ApoB-100target
CPG 10101Toll-like receptor 9target
GEM-231cAMP-dependent protein kinase type II-alpha regulatory subunittarget
GEM-231cAMP-dependent protein kinase type I-alpha regulatory subunittarget
EteplirsenDMD-001 gene (exon 51 target site)target
ApatorsenHeat shock protein beta-1target
AEG35156E3 ubiquitin-protein ligase XIAPtarget
AprinocarsenProtein kinase C alpha typetarget
Fomivirsen30 kDa immediate-early protein 2target
Fomivirsen45 kDa immediate-early protein 2target
NusinersenExonucleaseenzyme
NusinersenSurvival motor neuron proteintarget
ISS-1018Toll-like receptor 9target
NF-kappaB DecoyNuclear factor NF-kappa-Btarget
InotersenTransthyretin mRNAtarget
Adenylyl-(3'-5')-uridine 3'-monophosphateDiphtheria toxintarget
ViltolarsenDMD gene (exon 53 viltolarsen target site)target