EpiCept NP-1 is a prescription topical analgesic cream designed to provide effective, long-term relief from the pain of peripheral neuropathies. Peripheral neuropathies are medical conditions caused by damage to the... The peripheral nervous system includes nerves that run from the brain and spinal cord to the rest of the body.
- Mechanism
- Curator reviewed
The mechanism(s) of action are unclear for Epicept. Both ketamine and amitriptyline inhibit N-methyl-D-aspartate receptors in neuronal preparations and may be involved in sensitization of tetrodotoxin-resistant Na+ currents in nociceptors by blocking Na+ channels. In producing antihyperalgesia with pretreatment, but not posttreatment, regimens, ketamine and amitriptyline resemble the profile of a µ-opioid receptor agonist. In addition to the above effects, amitriptyline also inhibits noradrenaline, 5-HT, and adenosine uptake; inter-acts with opioid mechanisms; blocks Ca2+ channels; and blocks cholinergic, histamine H1, 5-HT2, and {alpha}-adrenergic receptors. Accordingly there are many possible mechanisms at work.
- Primary indication
- Investigated for use/treatment in neuropathy (diabetic) and pain (acute or chronic).Curator reviewed
- Formula / weight
- C10H15N3O2 · 209.245 g/mol (avg)
Resolves to
FKZUPMCBVURANR-UHFFFAOYSA-NSMILESCC1=CC(=C(NCCCN)C=C1)[N+]([O-])=OWhat you can answer from here — as of April 02, 2025
Which drugs share a target with Epicept NP-1, and which of those have an active Phase 3 trial?
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