Alpha-1D adrenergic receptor
Details
- Name
- Alpha-1D adrenergic receptor
- Kind
- protein
- Synonyms
- ADRA1A
- Alpha-1A adrenergic receptor
- Alpha-1D adrenoceptor
- Alpha-1D adrenoreceptor
- Alpha-adrenergic receptor 1a
- Gene Name
- ADRA1D
- UniProtKB Entry
- P25100Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0019001|Alpha-1D adrenergic receptor MTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGGGGGVVGAG SGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILS VACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCC TASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVP PDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKAS EVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLC WFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQ CRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEM QAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVE AVSLGVPHEVAEGATCQAYELADYSNLRETDI
- Number of residues
- 572
- Molecular Weight
- 60462.205
- Theoretical pI
- 9.44
- GO Classification
- Functionsidentical protein bindingProcessesadenylate cyclase-modulating G protein-coupled receptor signaling pathway / G protein-coupled receptor signaling pathway / neuron-glial cell signaling / phospholipase C-activating G protein-coupled receptor signaling pathway / positive regulation of cell population proliferation / positive regulation of MAPK cascade
- General Function
- This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium
- Specific Function
- alpha1-adrenergic receptor activity
- Pfam Domain Function
- 7tm_1 (PF00001)
- Signal Regions
- Not Available
- Transmembrane Regions
- 96-121 134-159 170-192 214-238 252-275 349-373 381-405
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0019002|Alpha-1D adrenergic receptor (ADRA1D) ATGACTTTCCGCGATCTCCTGAGCGTCAGTTTCGAGGGACCCCGCCCGGACAGCAGCGCA GGGGGCTCCAGCGCGGGCGGCGGCGGGGGCAGCGCGGGCGGCGCGGCCCCCTCGGAGGGC CCGGCGGTGGGCGGCGTGCCGGGGGGCGCGGGCGGCGGCGGCGGCGTGGTGGGCGCAGGC AGCGGCGAGGACAACCGGAGCTCCGCGGGGGAGCCGGGGAGCGCGGGCGCGGGCGGCGAC GTGAATGGCACGGCGGCCGTCGGGGGACTGGTGGTGAGCGCGCAGGGCGTGGGCGTGGGC GTCTTCCTGGCAGCCTTCATCCTTATGGCCGTGGCAGGTAACCTGCTTGTCATCCTCTCA GTGGCCTGCAACCGCCACCTGCAGACCGTCACCAACTATTTCATCGTGAACCTGGCCGTG GCCGACCTGCTGCTGAGCGCCACCGTACTGCCCTTCTCGGCCACCATGGAGGTTCTGGGC TTCTGGGCCTTTGGCCGCGCCTTCTGCGACGTATGGGCCGCCGTGGACGTGCTGTGCTGC ACGGCCTCCATCCTCAGCCTCTGCACCATCTCCGTGGACCGGTACGTGGGCGTGCGCCAC TCACTCAAGTACCCAGCCATCATGACCGAGCGCAAGGCGGCCGCCATCCTGGCCCTGCTC TGGGTCGTAGCCCTGGTGGTGTCCGTAGGGCCCCTGCTGGGCTGGAAGGAGCCCGTGCCC CCTGACGAGCGCTTCTGCGGTATCACCGAGGAGGCGGGCTACGCTGTCTTCTCCTCCGTG TGCTCCTTCTACCTGCCCATGGCGGTCATCGTGGTCATGTACTGCCGCGTGTACGTGGTC GCGCGCAGCACCACGCGCAGCCTCGAGGCGGGCGTCAAGCGCGAGCGAGGCAAGGCCTCC GAGGTGGTGCTGCGCATCCACTGTCGCGGCGCGGCCACGGGCGCCGACGGGGCGCACGGC ATGCGCAGCGCCAAGGGCCACACCTTCCGCAGCTCGCTCTCCGTGCGCCTGCTCAAGTTC TCCCGTGAGAAGAAAGCGGCCAAGACTCTGGCCATCGTCGTGGGTGTCTTCGTGCTCTGC TGGTTCCCTTTCTTCTTTGTCCTGCCGCTCGGCTCCTTGTTCCCGCAGCTGAAGCCATCG GAGGGCGTCTTCAAGGTCATCTTCTGGCTCGGCTACTTCAACAGCTGCGTGAACCCGCTC ATCTACCCCTGTTCCAGCCGCGAGTTCAAGCGCGCCTTCCTCCGTCTCCTGCGCTGCCAG TGCCGTCGTCGCCGGCGCCGCCGCCCTCTCTGGCGTGTCTACGGCCACCACTGGCGGGCC TCCACCAGCGGCCTGCGCCAGGACTGCGCCCCGAGTTCGGGCGACGCGCCCCCCGGAGCG CCGCTGGCCCTCACCGCGCTCCCCGACCCCGACCCCGAACCCCCAGGCACGCCCGAGATG CAGGCTCCGGTCGCCAGCCGTCGAAAGCCACCCAGCGCCTTCCGCGAGTGGAGGCTGCTG GGGCCGTTCCGGAGACCCACGACCCAGCTGCGCGCCAAAGTCTCCAGCCTGTCGCACAAG ATCCGCGCCGGGGGCGCGCAGCGCGCAGAGGCAGCGTGCGCCCAGCGCTCAGAGGTGGAG GCTGTGTCCCTAGGCGTCCCACACGAGGTGGCCGAGGGCGCCACCTGCCAGGCCTACGAA TTGGCCGACTACAGCAACCTACGGGAGACCGATATTTAA
- Chromosome Location
- 20
- Locus
- 20p13
- External Identifiers
Resource Link UniProtKB ID P25100 UniProtKB Entry Name ADA1D_HUMAN GenBank Protein ID 177807 GenBank Gene ID M76446 GeneCard ID ADRA1D GenAtlas ID ADRA1D HGNC ID HGNC:280 KEGG ID hsa:146 IUPHAR/Guide To Pharmacology ID 24 NCBI Gene ID 146 - General References
- Bruno JF, Whittaker J, Song JF, Berelowitz M: Molecular cloning and sequencing of a cDNA encoding a human alpha 1A adrenergic receptor. Biochem Biophys Res Commun. 1991 Sep 30;179(3):1485-90. [Article]
- Forray C, Bard JA, Wetzel JM, Chiu G, Shapiro E, Tang R, Lepor H, Hartig PR, Weinshank RL, Branchek TA, et al.: The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype. Mol Pharmacol. 1994 Apr;45(4):703-8. [Article]
- Schwinn DA, Johnston GI, Page SO, Mosley MJ, Wilson KH, Worman NP, Campbell S, Fidock MD, Furness LM, Parry-Smith DJ, et al.: Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues. J Pharmacol Exp Ther. 1995 Jan;272(1):134-42. [Article]
- Weinberg DH, Trivedi P, Tan CP, Mitra S, Perkins-Barrow A, Borkowski D, Strader CD, Bayne M: Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c. Biochem Biophys Res Commun. 1994 Jun 30;201(3):1296-304. [Article]
- Esbenshade TA, Hirasawa A, Tsujimoto G, Tanaka T, Yano J, Minneman KP, Murphy TJ: Cloning of the human alpha 1d-adrenergic receptor and inducible expression of three human subtypes in SK-N-MC cells. Mol Pharmacol. 1995 May;47(5):977-85. [Article]
- Deloukas P, Matthews LH, Ashurst J, Burton J, Gilbert JG, Jones M, Stavrides G, Almeida JP, Babbage AK, Bagguley CL, Bailey J, Barlow KF, Bates KN, Beard LM, Beare DM, Beasley OP, Bird CP, Blakey SE, Bridgeman AM, Brown AJ, Buck D, Burrill W, Butler AP, Carder C, Carter NP, Chapman JC, Clamp M, Clark G, Clark LN, Clark SY, Clee CM, Clegg S, Cobley VE, Collier RE, Connor R, Corby NR, Coulson A, Coville GJ, Deadman R, Dhami P, Dunn M, Ellington AG, Frankland JA, Fraser A, French L, Garner P, Grafham DV, Griffiths C, Griffiths MN, Gwilliam R, Hall RE, Hammond S, Harley JL, Heath PD, Ho S, Holden JL, Howden PJ, Huckle E, Hunt AR, Hunt SE, Jekosch K, Johnson CM, Johnson D, Kay MP, Kimberley AM, King A, Knights A, Laird GK, Lawlor S, Lehvaslaiho MH, Leversha M, Lloyd C, Lloyd DM, Lovell JD, Marsh VL, Martin SL, McConnachie LJ, McLay K, McMurray AA, Milne S, Mistry D, Moore MJ, Mullikin JC, Nickerson T, Oliver K, Parker A, Patel R, Pearce TA, Peck AI, Phillimore BJ, Prathalingam SR, Plumb RW, Ramsay H, Rice CM, Ross MT, Scott CE, Sehra HK, Shownkeen R, Sims S, Skuce CD, Smith ML, Soderlund C, Steward CA, Sulston JE, Swann M, Sycamore N, Taylor R, Tee L, Thomas DW, Thorpe A, Tracey A, Tromans AC, Vaudin M, Wall M, Wallis JM, Whitehead SL, Whittaker P, Willey DL, Williams L, Williams SA, Wilming L, Wray PW, Hubbard T, Durbin RM, Bentley DR, Beck S, Rogers J: The DNA sequence and comparative analysis of human chromosome 20. Nature. 2001 Dec 20-27;414(6866):865-71. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Dapiprazole approved yes target antagonist Details Tamsulosin approved, investigational unknown target antagonist Details Methotrimeprazine approved, investigational unknown target antagonist Details Norepinephrine approved yes target agonist Details Doxazosin approved yes target antagonist Details Terazosin approved yes target antagonist Details Alfuzosin approved, investigational yes target antagonist Details Dronedarone approved yes target antagonist Details Sertindole approved, investigational, withdrawn unknown target Details R450 investigational unknown target Details Epicept NP-1 investigational unknown target Details Silodosin approved yes target antagonist Details Droxidopa approved, investigational yes target agonist Details Ocaperidone investigational unknown target Details Prazosin approved yes target antagonist Details Phenylephrine approved yes target agonist Details Pergolide approved, investigational, vet_approved, withdrawn unknown target agonist Details Bromocriptine approved, investigational, withdrawn unknown target agonist Details Nicardipine approved, investigational unknown target antagonist Details Amitriptyline approved no target antagonist Details Nortriptyline approved no target antagonist Details Imipramine approved no target antagonist Details Ergotamine approved yes target partial agonist Details Doxepin approved, investigational unknown target antagonist Details Xylometazoline approved, investigational unknown target agonist Details Epinephrine approved, vet_approved unknown target antagonist Details Carvedilol approved, investigational unknown target antagonist Details Clonidine approved unknown target agonist Details Fenoldopam approved unknown target inhibitor Details Cabergoline approved unknown target binder Details Midodrine approved unknown target agonist Details Methoxamine approved, investigational unknown target binder Details Phenoxybenzamine approved unknown target antagonist Details Oxymetazoline approved, investigational unknown target agonist Details Cirazoline experimental yes target partial agonist Details Quinidine approved, investigational unknown target antagonist Details Verapamil approved unknown target antagonist Details Racepinephrine approved yes target antagonist Details Pizotifen approved unknown target antagonist Details Brexpiprazole approved, investigational unknown target antagonist Details 4-Methoxyamphetamine experimental, illicit yes target agonist Details Clorotepine experimental yes target inhibitor Details Fluanisone experimental yes target inhibitor Details Levonordefrin approved yes target inhibitor Details Indoramin approved, withdrawn yes target inhibitor Details Medetomidine experimental, vet_approved yes target inhibitor Details Trimazosin experimental yes target modulator Details Bunazosin investigational yes target modulator Details Moxisylyte approved, investigational yes target modulator Details Armodafinil approved, investigational yes target agonist Details Siramesine investigational yes target inhibitor Details