Temocapril

DB08836InvestigationalSmall molecule

Temocapril is a prodrug-type angiotensin-I converting enzyme (ACE) inhibitor not approved for use in the United States, but is approved in Japan and South Korea. Temocapril can also be used... Temocapril can also be used in hemodialysis patients without risk of serious accumulation.

Chemical structure of Temocapril
Primary indication
Temocapril is an ACE inhibitor primarily indicated in the treatment of hypertension and congestive heart failure, diabetic nephropathy, and improvement of prognosis for coronary artery diseases (including acute myocardial infarction).Curator reviewed
Formula / weight
C23H28N2O5S2 · 476.609 g/mol (avg)
Code names
CS-622

Resolves to

Compound
UNII18IZ008EU6CAS111902-57-9ChEMBLCHEMBL2110627ChEBI135771PubChem443874KEGGD08566
Clinical / RWD
ATCC09AA14
Structure
InChIKeyFIQOFIRCTOWDOW-BJLQDIEVSA-NSMILESCCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@H]1CS[C@@H](CN(CC(O)=O)C1=O)C1=CC=CS1
Targets
P12821ACE
Transporters
P46059SLC15A1P46721SLCO1A2

What you can answer from here — as of September 13, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action
Listed above
2TransportersSubstrate / inhibitor direction, not just membership
Listed above
953Drug interactionsStructured to mechanism, not free text
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1Clinical trialPhase, status and sponsor resolved per trial
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1ATC codeIncluding every combination product, plus 12 drug categories
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8+ReferencesStructured and connected to the statements they support
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